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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Metallosphaera cuprina (strain Ar-4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Protein family/group databases

MEROPSiT01.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
Ordered Locus Names:Mcup_1983Imported
OrganismiMetallosphaera cuprina (strain Ar-4)Imported
Taxonomic identifieri1006006 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000007812 Componenti: Chromosome

Subcellular locationi

F4G1S8:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, ProteasomeUniRule annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi1006006.Mcup_1983.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 32PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00971. Archaea.
COG0638. LUCA.
KOiK03432.
OMAiQMGYDRA.
OrthoDBiPOG093Z086S.

Family and domain databases

CDDicd03756. proteasome_alpha_archeal. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_A. Proteasome_A_A. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR019982. Proteasome_asu_arc.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03633. arc_protsome_A. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F4G1S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFGPAAMGY DRAITIFSPD GSLYQVDYAF EAVKKGWTTL GVKTRNAVVI
60 70 80 90 100
LGEKKKASQL LDVDSIEKVF LLDDHVGCSF AGLASDGRIL IDYARNSSLQ
110 120 130 140 150
HRLVYDEPIS IDYLTKLISD VKQMYTQHGG VRPFGVALIV GGVDKGVTKL
160 170 180 190 200
FMTEPSGQFM PYQAVAIGQG GYNATDYLEK NYKEDLTVED TILLALNALK
210 220 230 240
ATLKPGEKLS PNNVEIGFAT KDGQFRKMGT EERSSYIQKI
Length:240
Mass (Da):26,365
Last modified:June 28, 2011 - v1
Checksum:i2C061FCBAAC137BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002656 Genomic DNA. Translation: AEB96085.1.
RefSeqiWP_013738583.1. NC_015435.1.

Genome annotation databases

EnsemblBacteriaiAEB96085; AEB96085; Mcup_1983.
GeneIDi10494171.
KEGGimcn:Mcup_1983.
PATRICifig|1006006.8.peg.1987.

Similar proteinsi

Entry informationi

Entry nameiF4G1S8_METCR
AccessioniPrimary (citable) accession number: F4G1S8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported