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Protein

DNA ligase

Gene

lig

Organism
Metallosphaera cuprina (strain Ar-4)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei259 – 2591ATPUniRule annotation
Active sitei261 – 2611N6-AMP-lysine intermediateUniRule annotation
Binding sitei266 – 2661ATPUniRule annotation
Binding sitei281 – 2811ATPUniRule annotation
Binding sitei311 – 3111ATPUniRule annotation
Binding sitei351 – 3511ATPUniRule annotation
Binding sitei428 – 4281ATPUniRule annotation
Binding sitei434 – 4341ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCUP1006006:GHTI-1950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mcup_1923Imported
OrganismiMetallosphaera cuprina (strain Ar-4)Imported
Taxonomic identifieri1006006 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000007812 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1006006.Mcup_1923.

Structurei

3D structure databases

ProteinModelPortaliF4G1D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4G1D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFKLIAEYF DKLEKISSRI QLTSLLSDLF KNTDKNTISK VVYIIQGRLW
60 70 80 90 100
PDFAGMPEIG MGEKFLIKSI AMAFSKKEEE IEKIYKRIGD LGEVAYTLKN
110 120 130 140 150
ESKSSNILSF INNTTHDSEL EVEEVYEDLV KIATSSGEGS RDVKIRTFAG
160 170 180 190 200
ILRKATPLEA KYLVRFVEGR LRLGIGDATV LDALAITFGG STEYRPIVER
210 220 230 240 250
AYNLRADLGE IAKIIDAYGI EKLKTISPTP GIPIRPMLAE RLADPAEIME
260 270 280 290 300
KVNGNALVDY KYDGERAQIH KKGEDIYIFS RRMENITNQY IDVVDYVKKF
310 320 330 340 350
INGDNFIIEG EIVPIDPESG EMRPFQELMH RRRKNDIYQA INEYPVSLFL
360 370 380 390 400
FDLMLLNGQD YTTRPLLDRR AALESIIKEN DKVRIASHIM VNDVNKLKEY
410 420 430 440 450
FYQAVADGAE GVMIKSVSPD SVYKAGSRGW LWIKLKRDYQ SEMADTVDLV
460 470 480 490 500
VVGAFYGKGK RGGKFSSLLM AAYNPEKDVF ETVCKVASGF SDQELDELQK
510 520 530 540 550
KIEQLKRDEK HPRVISNMSP DVWVSPAIVA EIIGAEITIS PLHTCCKNDK
560 570 580 590
AGLSIRFPRF VRWRDDKSPE DATTNQEIME MYSRQLKKIE DKPVDENI
Length:598
Mass (Da):68,054
Last modified:June 28, 2011 - v1
Checksum:iEE741CD162684AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002656 Genomic DNA. Translation: AEB96025.1.
RefSeqiWP_013738523.1. NC_015435.1.
YP_004410509.1. NC_015435.1.

Genome annotation databases

EnsemblBacteriaiAEB96025; AEB96025; Mcup_1923.
GeneIDi10494111.
KEGGimcn:Mcup_1923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002656 Genomic DNA. Translation: AEB96025.1.
RefSeqiWP_013738523.1. NC_015435.1.
YP_004410509.1. NC_015435.1.

3D structure databases

ProteinModelPortaliF4G1D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1006006.Mcup_1923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB96025; AEB96025; Mcup_1923.
GeneIDi10494111.
KEGGimcn:Mcup_1923.

Phylogenomic databases

KOiK10747.
OMAiPQVVIEV.

Enzyme and pathway databases

BioCyciMCUP1006006:GHTI-1950-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Metallosphaera cuprina, a metal sulfide-oxidizing archaeon from a hot spring."
    Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.
    J. Bacteriol. 193:3387-3388(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ar-4Imported.

Entry informationi

Entry nameiF4G1D8_METCR
AccessioniPrimary (citable) accession number: F4G1D8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 24, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.