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Protein

DNA ligase

Gene

lig

Organism
Metallosphaera cuprina (strain Ar-4)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259ATPUniRule annotation1
Active sitei261N6-AMP-lysine intermediateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei281ATPUniRule annotation1
Binding sitei311ATPUniRule annotation1
Binding sitei351ATPUniRule annotation1
Binding sitei428ATPUniRule annotation1
Binding sitei434ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCUP1006006:G1GWB-1841-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mcup_1923Imported
OrganismiMetallosphaera cuprina (strain Ar-4)Imported
Taxonomic identifieri1006006 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
Proteomesi
  • UP000007812 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi1006006.Mcup_1923

Structurei

3D structure databases

ProteinModelPortaliF4G1D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 474DNA_LIGASE_A3InterPro annotationAdd BLAST136

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili488 – 508Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F4G1D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFKLIAEYF DKLEKISSRI QLTSLLSDLF KNTDKNTISK VVYIIQGRLW
60 70 80 90 100
PDFAGMPEIG MGEKFLIKSI AMAFSKKEEE IEKIYKRIGD LGEVAYTLKN
110 120 130 140 150
ESKSSNILSF INNTTHDSEL EVEEVYEDLV KIATSSGEGS RDVKIRTFAG
160 170 180 190 200
ILRKATPLEA KYLVRFVEGR LRLGIGDATV LDALAITFGG STEYRPIVER
210 220 230 240 250
AYNLRADLGE IAKIIDAYGI EKLKTISPTP GIPIRPMLAE RLADPAEIME
260 270 280 290 300
KVNGNALVDY KYDGERAQIH KKGEDIYIFS RRMENITNQY IDVVDYVKKF
310 320 330 340 350
INGDNFIIEG EIVPIDPESG EMRPFQELMH RRRKNDIYQA INEYPVSLFL
360 370 380 390 400
FDLMLLNGQD YTTRPLLDRR AALESIIKEN DKVRIASHIM VNDVNKLKEY
410 420 430 440 450
FYQAVADGAE GVMIKSVSPD SVYKAGSRGW LWIKLKRDYQ SEMADTVDLV
460 470 480 490 500
VVGAFYGKGK RGGKFSSLLM AAYNPEKDVF ETVCKVASGF SDQELDELQK
510 520 530 540 550
KIEQLKRDEK HPRVISNMSP DVWVSPAIVA EIIGAEITIS PLHTCCKNDK
560 570 580 590
AGLSIRFPRF VRWRDDKSPE DATTNQEIME MYSRQLKKIE DKPVDENI
Length:598
Mass (Da):68,054
Last modified:June 28, 2011 - v1
Checksum:iEE741CD162684AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002656 Genomic DNA Translation: AEB96025.1
RefSeqiWP_013738523.1, NC_015435.1

Genome annotation databases

EnsemblBacteriaiAEB96025; AEB96025; Mcup_1923
GeneIDi10494111
KEGGimcn:Mcup_1923
PATRICifig|1006006.8.peg.1926

Similar proteinsi

Entry informationi

Entry nameiF4G1D8_METCR
AccessioniPrimary (citable) accession number: F4G1D8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health