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F4G1D8

- F4G1D8_METCR

UniProt

F4G1D8 - F4G1D8_METCR

Protein

DNA ligase

Gene

lig

Organism
Metallosphaera cuprina (strain Ar-4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei259 – 2591ATPUniRule annotation
    Active sitei261 – 2611N6-AMP-lysine intermediateUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei281 – 2811ATPUniRule annotation
    Binding sitei311 – 3111ATPUniRule annotation
    Binding sitei351 – 3511ATPUniRule annotation
    Binding sitei428 – 4281ATPUniRule annotation
    Binding sitei434 – 4341ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMCUP1006006:GHTI-1950-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mcup_1923Imported
    OrganismiMetallosphaera cuprina (strain Ar-4)Imported
    Taxonomic identifieri1006006 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
    ProteomesiUP000007812: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF4G1D8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiLDPSGYN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F4G1D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFKLIAEYF DKLEKISSRI QLTSLLSDLF KNTDKNTISK VVYIIQGRLW    50
    PDFAGMPEIG MGEKFLIKSI AMAFSKKEEE IEKIYKRIGD LGEVAYTLKN 100
    ESKSSNILSF INNTTHDSEL EVEEVYEDLV KIATSSGEGS RDVKIRTFAG 150
    ILRKATPLEA KYLVRFVEGR LRLGIGDATV LDALAITFGG STEYRPIVER 200
    AYNLRADLGE IAKIIDAYGI EKLKTISPTP GIPIRPMLAE RLADPAEIME 250
    KVNGNALVDY KYDGERAQIH KKGEDIYIFS RRMENITNQY IDVVDYVKKF 300
    INGDNFIIEG EIVPIDPESG EMRPFQELMH RRRKNDIYQA INEYPVSLFL 350
    FDLMLLNGQD YTTRPLLDRR AALESIIKEN DKVRIASHIM VNDVNKLKEY 400
    FYQAVADGAE GVMIKSVSPD SVYKAGSRGW LWIKLKRDYQ SEMADTVDLV 450
    VVGAFYGKGK RGGKFSSLLM AAYNPEKDVF ETVCKVASGF SDQELDELQK 500
    KIEQLKRDEK HPRVISNMSP DVWVSPAIVA EIIGAEITIS PLHTCCKNDK 550
    AGLSIRFPRF VRWRDDKSPE DATTNQEIME MYSRQLKKIE DKPVDENI 598
    Length:598
    Mass (Da):68,054
    Last modified:June 28, 2011 - v1
    Checksum:iEE741CD162684AFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002656 Genomic DNA. Translation: AEB96025.1.
    RefSeqiWP_013738523.1. NC_015435.1.
    YP_004410509.1. NC_015435.1.

    Genome annotation databases

    EnsemblBacteriaiAEB96025; AEB96025; Mcup_1923.
    GeneIDi10494111.
    KEGGimcn:Mcup_1923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002656 Genomic DNA. Translation: AEB96025.1 .
    RefSeqi WP_013738523.1. NC_015435.1.
    YP_004410509.1. NC_015435.1.

    3D structure databases

    ProteinModelPortali F4G1D8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEB96025 ; AEB96025 ; Mcup_1923 .
    GeneIDi 10494111.
    KEGGi mcn:Mcup_1923.

    Phylogenomic databases

    KOi K10747.
    OMAi LDPSGYN.

    Enzyme and pathway databases

    BioCyci MCUP1006006:GHTI-1950-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Metallosphaera cuprina, a metal sulfide-oxidizing archaeon from a hot spring."
      Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.
      J. Bacteriol. 193:3387-3388(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ar-4Imported.

    Entry informationi

    Entry nameiF4G1D8_METCR
    AccessioniPrimary (citable) accession number: F4G1D8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3