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F4G1D8 (F4G1D8_METCR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Mcup_1923 EMBL AEB96025.1
OrganismMetallosphaera cuprina (strain Ar-4) [Complete proteome] [HAMAP] EMBL AEB96025.1
Taxonomic identifier1006006 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2611N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2591ATP By similarity HAMAP-Rule MF_00407
Binding site2661ATP By similarity HAMAP-Rule MF_00407
Binding site2811ATP By similarity HAMAP-Rule MF_00407
Binding site3111ATP By similarity HAMAP-Rule MF_00407
Binding site3511ATP By similarity HAMAP-Rule MF_00407
Binding site4281ATP By similarity HAMAP-Rule MF_00407
Binding site4341ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
F4G1D8 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: EE741CD162684AFC

FASTA59868,054
        10         20         30         40         50         60 
MKFKLIAEYF DKLEKISSRI QLTSLLSDLF KNTDKNTISK VVYIIQGRLW PDFAGMPEIG 

        70         80         90        100        110        120 
MGEKFLIKSI AMAFSKKEEE IEKIYKRIGD LGEVAYTLKN ESKSSNILSF INNTTHDSEL 

       130        140        150        160        170        180 
EVEEVYEDLV KIATSSGEGS RDVKIRTFAG ILRKATPLEA KYLVRFVEGR LRLGIGDATV 

       190        200        210        220        230        240 
LDALAITFGG STEYRPIVER AYNLRADLGE IAKIIDAYGI EKLKTISPTP GIPIRPMLAE 

       250        260        270        280        290        300 
RLADPAEIME KVNGNALVDY KYDGERAQIH KKGEDIYIFS RRMENITNQY IDVVDYVKKF 

       310        320        330        340        350        360 
INGDNFIIEG EIVPIDPESG EMRPFQELMH RRRKNDIYQA INEYPVSLFL FDLMLLNGQD 

       370        380        390        400        410        420 
YTTRPLLDRR AALESIIKEN DKVRIASHIM VNDVNKLKEY FYQAVADGAE GVMIKSVSPD 

       430        440        450        460        470        480 
SVYKAGSRGW LWIKLKRDYQ SEMADTVDLV VVGAFYGKGK RGGKFSSLLM AAYNPEKDVF 

       490        500        510        520        530        540 
ETVCKVASGF SDQELDELQK KIEQLKRDEK HPRVISNMSP DVWVSPAIVA EIIGAEITIS 

       550        560        570        580        590 
PLHTCCKNDK AGLSIRFPRF VRWRDDKSPE DATTNQEIME MYSRQLKKIE DKPVDENI 

« Hide

References

[1]"Complete genome sequence of Metallosphaera cuprina, a metal sulfide-oxidizing archaeon from a hot spring."
Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.
J. Bacteriol. 193:3387-3388(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ar-4 EMBL AEB96025.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002656 Genomic DNA. Translation: AEB96025.1.
RefSeqYP_004410509.1. NC_015435.1.

3D structure databases

ProteinModelPortalF4G1D8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEB96025; AEB96025; Mcup_1923.
GeneID10494111.
KEGGmcn:Mcup_1923.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMAYIARFVV.

Enzyme and pathway databases

BioCycMCUP1006006:GHTI-1950-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4G1D8_METCR
AccessionPrimary (citable) accession number: F4G1D8
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 19, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)