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F4G1D8

- F4G1D8_METCR

UniProt

F4G1D8 - F4G1D8_METCR

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Protein
DNA ligase
Gene
lig, Mcup_1923
Organism
Metallosphaera cuprina (strain Ar-4)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei259 – 2591ATP By similarityUniRule annotation
Active sitei261 – 2611N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei266 – 2661ATP By similarityUniRule annotation
Binding sitei281 – 2811ATP By similarityUniRule annotation
Binding sitei311 – 3111ATP By similarityUniRule annotation
Binding sitei351 – 3511ATP By similarityUniRule annotation
Binding sitei428 – 4281ATP By similarityUniRule annotation
Binding sitei434 – 4341ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMCUP1006006:GHTI-1950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mcup_1923Imported
OrganismiMetallosphaera cuprina (strain Ar-4)Imported
Taxonomic identifieri1006006 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeMetallosphaera
ProteomesiUP000007812: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF4G1D8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4G1D8-1 [UniParc]FASTAAdd to Basket

« Hide

MKFKLIAEYF DKLEKISSRI QLTSLLSDLF KNTDKNTISK VVYIIQGRLW    50
PDFAGMPEIG MGEKFLIKSI AMAFSKKEEE IEKIYKRIGD LGEVAYTLKN 100
ESKSSNILSF INNTTHDSEL EVEEVYEDLV KIATSSGEGS RDVKIRTFAG 150
ILRKATPLEA KYLVRFVEGR LRLGIGDATV LDALAITFGG STEYRPIVER 200
AYNLRADLGE IAKIIDAYGI EKLKTISPTP GIPIRPMLAE RLADPAEIME 250
KVNGNALVDY KYDGERAQIH KKGEDIYIFS RRMENITNQY IDVVDYVKKF 300
INGDNFIIEG EIVPIDPESG EMRPFQELMH RRRKNDIYQA INEYPVSLFL 350
FDLMLLNGQD YTTRPLLDRR AALESIIKEN DKVRIASHIM VNDVNKLKEY 400
FYQAVADGAE GVMIKSVSPD SVYKAGSRGW LWIKLKRDYQ SEMADTVDLV 450
VVGAFYGKGK RGGKFSSLLM AAYNPEKDVF ETVCKVASGF SDQELDELQK 500
KIEQLKRDEK HPRVISNMSP DVWVSPAIVA EIIGAEITIS PLHTCCKNDK 550
AGLSIRFPRF VRWRDDKSPE DATTNQEIME MYSRQLKKIE DKPVDENI 598
Length:598
Mass (Da):68,054
Last modified:June 28, 2011 - v1
Checksum:iEE741CD162684AFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002656 Genomic DNA. Translation: AEB96025.1.
RefSeqiWP_013738523.1. NC_015435.1.
YP_004410509.1. NC_015435.1.

Genome annotation databases

EnsemblBacteriaiAEB96025; AEB96025; Mcup_1923.
GeneIDi10494111.
KEGGimcn:Mcup_1923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002656 Genomic DNA. Translation: AEB96025.1 .
RefSeqi WP_013738523.1. NC_015435.1.
YP_004410509.1. NC_015435.1.

3D structure databases

ProteinModelPortali F4G1D8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB96025 ; AEB96025 ; Mcup_1923 .
GeneIDi 10494111.
KEGGi mcn:Mcup_1923.

Phylogenomic databases

KOi K10747.
OMAi LDPSGYN.

Enzyme and pathway databases

BioCyci MCUP1006006:GHTI-1950-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Metallosphaera cuprina, a metal sulfide-oxidizing archaeon from a hot spring."
    Liu L.J., You X.Y., Zheng H., Wang S., Jiang C.Y., Liu S.J.
    J. Bacteriol. 193:3387-3388(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ar-4Imported.

Entry informationi

Entry nameiF4G1D8_METCR
AccessioniPrimary (citable) accession number: F4G1D8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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