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F4FTX5

- F4FTX5_LACBN

UniProt

F4FTX5 - F4FTX5_LACBN

Protein

Thymidine kinase

Gene

tdk

Organism
Lactobacillus buchneri (strain NRRL B-30929)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei117 – 1171Proton acceptorUniRule annotation
    Metal bindingi174 – 1741ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi211 – 2111ZincUniRule annotation
    Metal bindingi214 – 2141ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 478ATPUniRule annotation
    Nucleotide bindingi116 – 1194ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLBUC511437:GJNY-902-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Lbuc_0854Imported
    OrganismiLactobacillus buchneri (strain NRRL B-30929)Imported
    Taxonomic identifieri511437 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000007811: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F4FTX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLANFLII IDFQNFFCIM EEKLLRKKVD ILAQLFYRYG AMNSGKTIEI    50
    IKVAHNYEEQ NKSVIIMTSA LDTREKQGMI ESRIGLERKA EPIREDTNVF 100
    DLVQELNPHA SCILIDEAQF LKKKHVMELA RIVDELNVPV MAFGLKNDFQ 150
    NNLFEGSKYL LLYADKIEEM KTICWFCGKK AIMNLRFHNG EPVYEGEQIQ 200
    MGGNESYYPV CRKHYYNPPI K 221
    Length:221
    Mass (Da):25,829
    Last modified:June 28, 2011 - v1
    Checksum:i1872649C9212D512
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002652 Genomic DNA. Translation: AEB73113.1.
    RefSeqiYP_004398176.1. NC_015428.1.

    Genome annotation databases

    EnsemblBacteriaiAEB73113; AEB73113; Lbuc_0854.
    GeneIDi10525011.
    KEGGilbh:Lbuc_0854.
    PATRICi54462871. VBILacBuc105504_0945.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002652 Genomic DNA. Translation: AEB73113.1 .
    RefSeqi YP_004398176.1. NC_015428.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEB73113 ; AEB73113 ; Lbuc_0854 .
    GeneIDi 10525011.
    KEGGi lbh:Lbuc_0854.
    PATRICi 54462871. VBILacBuc105504_0945.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci LBUC511437:GJNY-902-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Lactobacillus buchneri NRRL B-30929, a novel strain from a commercial ethanol plant."
      US DOE Joint Genome Institute
      Liu S., Leathers T.D., Copeland A., Chertkov O., Goodwin L., Mills D.A.
      J. Bacteriol. 193:4019-4020(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NRRL B-30929Imported.

    Entry informationi

    Entry nameiF4FTX5_LACBN
    AccessioniPrimary (citable) accession number: F4FTX5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3