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F4FTX5

- F4FTX5_LACBN

UniProt

F4FTX5 - F4FTX5_LACBN

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Protein

Thymidine kinase

Gene
tdk, Lbuc_0854
Organism
Lactobacillus buchneri (strain NRRL B-30929)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton acceptor By similarityUniRule annotation
Metal bindingi174 – 1741Zinc By similarityUniRule annotation
Metal bindingi177 – 1771Zinc By similarityUniRule annotation
Metal bindingi211 – 2111Zinc By similarityUniRule annotation
Metal bindingi214 – 2141Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 478ATP By similarityUniRule annotation
Nucleotide bindingi116 – 1194ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLBUC511437:GJNY-902-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Lbuc_0854Imported
OrganismiLactobacillus buchneri (strain NRRL B-30929)Imported
Taxonomic identifieri511437 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000007811: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4FTX5-1 [UniParc]FASTAAdd to Basket

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MRVLANFLII IDFQNFFCIM EEKLLRKKVD ILAQLFYRYG AMNSGKTIEI    50
IKVAHNYEEQ NKSVIIMTSA LDTREKQGMI ESRIGLERKA EPIREDTNVF 100
DLVQELNPHA SCILIDEAQF LKKKHVMELA RIVDELNVPV MAFGLKNDFQ 150
NNLFEGSKYL LLYADKIEEM KTICWFCGKK AIMNLRFHNG EPVYEGEQIQ 200
MGGNESYYPV CRKHYYNPPI K 221
Length:221
Mass (Da):25,829
Last modified:June 28, 2011 - v1
Checksum:i1872649C9212D512
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002652 Genomic DNA. Translation: AEB73113.1.
RefSeqiYP_004398176.1. NC_015428.1.

Genome annotation databases

EnsemblBacteriaiAEB73113; AEB73113; Lbuc_0854.
GeneIDi10525011.
KEGGilbh:Lbuc_0854.
PATRICi54462871. VBILacBuc105504_0945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002652 Genomic DNA. Translation: AEB73113.1 .
RefSeqi YP_004398176.1. NC_015428.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB73113 ; AEB73113 ; Lbuc_0854 .
GeneIDi 10525011.
KEGGi lbh:Lbuc_0854.
PATRICi 54462871. VBILacBuc105504_0945.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci LBUC511437:GJNY-902-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Lactobacillus buchneri NRRL B-30929, a novel strain from a commercial ethanol plant."
    US DOE Joint Genome Institute
    Liu S., Leathers T.D., Copeland A., Chertkov O., Goodwin L., Mills D.A.
    J. Bacteriol. 193:4019-4020(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NRRL B-30929Imported.

Entry informationi

Entry nameiF4FTX5_LACBN
AccessioniPrimary (citable) accession number: F4FTX5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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