ID   F4FEW8_MICM1            Unreviewed;       385 AA.
AC   F4FEW8;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE            EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN   Name=ligC {ECO:0000313|EMBL:AEB43680.1};
GN   OrderedLocusNames=VAB18032_12830 {ECO:0000313|EMBL:AEB43680.1};
OS   Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL
OS   B-24793 / AB-18-032) (Verrucosispora maris).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=263358 {ECO:0000313|EMBL:AEB43680.1, ECO:0000313|Proteomes:UP000008308};
RN   [1] {ECO:0000313|EMBL:AEB43680.1, ECO:0000313|Proteomes:UP000008308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB-18-032 {ECO:0000313|EMBL:AEB43680.1,
RC   ECO:0000313|Proteomes:UP000008308};
RX   PubMed=21551311; DOI=10.1128/JB.05041-11;
RA   Roh H., Uguru G.C., Ko H.J., Kim S., Kim B.Y., Goodfellow M., Bull A.T.,
RA   Kim K.H., Bibb M.J., Choi I.G., Stach J.E.;
RT   "Genome sequence of the abyssomicin- and proximicin-producing marine
RT   actinomycete Verrucosispora maris AB-18-032.";
RL   J. Bacteriol. 193:3391-3392(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572}.
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DR   EMBL; CP002638; AEB43680.1; -; Genomic_DNA.
DR   AlphaFoldDB; F4FEW8; -.
DR   STRING; 263358.VAB18032_12830; -.
DR   KEGG; vma:VAB18032_12830; -.
DR   eggNOG; COG1793; Bacteria.
DR   HOGENOM; CLU_008325_4_1_11; -.
DR   Proteomes; UP000008308; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07905; Adenylation_DNA_ligase_LigC; 1.
DR   CDD; cd07970; OBF_DNA_ligase_LigC; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR044119; Adenylation_LigC-like.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR044117; OBF_LigC-like.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AEB43680.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008308}.
FT   DOMAIN          137..250
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
SQ   SEQUENCE   385 AA;  42901 MW;  A94FCC9885D0EA41 CRC64;
     MICLTVVGGV WLTVAVDLPI NPPVEPMLAR SVASIPTGPG MTYEPKWDGF RCIIFRDGDE
     VELASRGGKL MTRYFPEVVE QARRQLPARC AVDGELIVIR RDSPNAAPRL DFELLAQRIH
     PAASRVKLLA ETTPADFVAF DLLALDGESL LDVPYPTRRA RLEQALAKVR PPVHVTQITT
     DADTARRWFD VFEGAGLDGL IAKPADLPYE PGKRLMFKVK HARTADVVVA GFRWHKSGPV
     VGSLLLGLYD DAQVLHHIGV SASFTMARRA ELLEELAPYR EVGAEHPWVH GDHERGQRIP
     GGVSRWTGTK NLEWEPLRPE LVVEVAYDAM EGDRFRHTAR FVRWRPDRDP LSCRYDQLDR
     PVRFDVDQVL RGDPTVTVGS GTGSA
//