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Protein

Alanine racemase

Gene

VAB18032_00795

Organism
Verrucosispora maris (strain AB-18-032)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (VAB18032_00795)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Active sitei261Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei309Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVMAR263358:GI1P-5263-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:VAB18032_00795Imported
OrganismiVerrucosispora maris (strain AB-18-032)Imported
Taxonomic identifieri263358 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeVerrucosispora
Proteomesi
  • UP000008308 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi263358.VAB18032_00795

Structurei

3D structure databases

ProteinModelPortaliF4FB98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini240 – 368Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

F4FB98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQAEVRVDL DAIRENVDRM RAGTSAELMA VVKADGYGHG MVPAARAALD
60 70 80 90 100
AGATWLGVCT LDEALALRAA GIDAPVLAWL LAPGLPLHTG VAADVDLGVA
110 120 130 140 150
SLPQLDEAVE ASRRAQRPAR VHLKIDTGLS RNGATVADWP ALLDAAAKAQ
160 170 180 190 200
ADGLVEVVGV WSHFVYADMP GHPTTDRQLA VFHEGLAMVE RAGLRPRYRH
210 220 230 240 250
LANSAATLTR PDTHFDLVRP GLAVYGLSPV AGETHGLRPA MTARARVMLT
260 270 280 290 300
KRVPAGTGVS YGHTYTTERD ANLAVVPLGY ADGVPRHASN TGPVQLGGRR
310 320 330 340 350
RTISGRVCMD QFVLDCGDDP VAAGDVATLF GSGADGEPTA DDWAEAVGTI
360 370
NYEIVTRFGS SRVPRVYDGT DS
Length:372
Mass (Da):39,264
Last modified:June 28, 2011 - v1
Checksum:i8A761BAFF5140175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002638 Genomic DNA Translation: AEB47243.1
RefSeqiWP_013735888.1, NC_015434.1

Genome annotation databases

EnsemblBacteriaiAEB47243; AEB47243; VAB18032_00795
KEGGivma:VAB18032_00795

Similar proteinsi

Entry informationi

Entry nameiF4FB98_VERMA
AccessioniPrimary (citable) accession number: F4FB98
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health