ID   F4F7F9_MICM1            Unreviewed;       341 AA.
AC   F4F7F9;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=3-oxoacyl-ACP synthase III {ECO:0000313|EMBL:AEK75497.1};
DE   SubName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III {ECO:0000313|EMBL:AEB44398.1};
GN   Name=abyA1 {ECO:0000313|EMBL:AEK75497.1};
GN   OrderedLocusNames=VAB18032_16460 {ECO:0000313|EMBL:AEB44398.1};
OS   Micromonospora maris (strain DSM 45365 / JCM 31040 / NBRC 109089 / NRRL
OS   B-24793 / AB-18-032) (Verrucosispora maris).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=263358 {ECO:0000313|EMBL:AEB44398.1, ECO:0000313|Proteomes:UP000008308};
RN   [1] {ECO:0000313|EMBL:AEK75497.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AB-18-032 {ECO:0000313|EMBL:AEK75497.1};
RX   PubMed=21656887; DOI=10.1002/cbic.201100172;
RA   Gottardi E.M., Krawczyk J.M., von Suchodoletz H., Schadt S., Muhlenweg A.,
RA   Uguru G.C., Pelzer S., Fiedler H.P., Bibb M.J., Stach J.E., Sussmuth R.D.;
RT   "Abyssomicin biosynthesis: formation of an unusual polyketide, antibiotic-
RT   feeding studies and genetic analysis.";
RL   ChemBioChem 12:1401-1410(2011).
RN   [2] {ECO:0000313|EMBL:AEB44398.1, ECO:0000313|Proteomes:UP000008308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB-18-032 {ECO:0000313|EMBL:AEB44398.1,
RC   ECO:0000313|Proteomes:UP000008308};
RX   PubMed=21551311; DOI=10.1128/JB.05041-11;
RA   Roh H., Uguru G.C., Ko H.J., Kim S., Kim B.Y., Goodfellow M., Bull A.T.,
RA   Kim K.H., Bibb M.J., Choi I.G., Stach J.E.;
RT   "Genome sequence of the abyssomicin- and proximicin-producing marine
RT   actinomycete Verrucosispora maris AB-18-032.";
RL   J. Bacteriol. 193:3391-3392(2011).
RN   [3] {ECO:0007829|PDB:5BY7}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
RA   Byrne M.J., Race P.R.;
RT   "The structure of AbyA1, a tetronic acid condensing enzyme from the
RT   Abyssomicin polyketide synthase.";
RL   Submitted (JUN-2015) to the PDB data bank.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. FabH family.
CC       {ECO:0000256|ARBA:ARBA00008642}.
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DR   EMBL; CP002638; AEB44398.1; -; Genomic_DNA.
DR   EMBL; JF752342; AEK75497.1; -; Genomic_DNA.
DR   RefSeq; WP_013733058.1; NC_015434.1.
DR   PDB; 5BY7; X-ray; 1.80 A; A/B/C/D=1-341.
DR   PDBsum; 5BY7; -.
DR   AlphaFoldDB; F4F7F9; -.
DR   SMR; F4F7F9; -.
DR   STRING; 263358.VAB18032_16460; -.
DR   KEGG; vma:VAB18032_16460; -.
DR   eggNOG; COG0332; Bacteria.
DR   HOGENOM; CLU_039592_3_1_11; -.
DR   Proteomes; UP000008308; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR013751; ACP_syn_III_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR34069; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3; 1.
DR   PANTHER; PTHR34069:SF2; BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III; 1.
DR   Pfam; PF08545; ACP_syn_III; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:5BY7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008308}.
FT   DOMAIN          119..199
FT                   /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08545"
FT   DOMAIN          254..325
FT                   /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08541"
SQ   SEQUENCE   341 AA;  36082 MW;  AEB9CAA2344575D7 CRC64;
     MTRTVSVLSA ASALPGPTVD NATLGRRLGM DRLWEQWVDA FIGTRTRHLA VDLDSGEIRH
     TLADLAHQAG SRALDAAGVT PEEVDLVVLG TATPDRLMPT TATVVADRLG IDGVPAYQLQ
     SGCSGAVQAL AVTRSLLLGG TARTALVLGG DVVARFYDLT ADLRKLPPAE FVNYVLFGDG
     VGAAVLRVGE VAGAAALRSV FTRLVGLGRE PGATLEWFGP TEDRNRPAAT EDYKAIERHV
     PDLAAEVVEE LLGELGWARD DLDYVLPPQL SGRMTALIVE RLKLPQATEV SCVAETGNNG
     NGIVFLQLER ALARLAGGQR ALGVSIESSK WIKSGFALEG L
//