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F4F695

- F4F695_VERMA

UniProt

F4F695 - F4F695_VERMA

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Protein

Probable DNA ligase

Gene
ligB, lig, VAB18032_28881
Organism
Verrucosispora maris (strain AB-18-032)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATP By similarityUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei216 – 2161ATP By similarityUniRule annotation
Binding sitei231 – 2311ATP By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei322 – 3221ATP By similarityUniRule annotation
Binding sitei394 – 3941ATP By similarityUniRule annotation
Binding sitei400 – 4001ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVMAR263358:GI1P-4863-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:VAB18032_28881Imported
OrganismiVerrucosispora maris (strain AB-18-032)Imported
Taxonomic identifieri263358 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeVerrucosispora
ProteomesiUP000008308: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4F695-1 [UniParc]FASTAAdd to Basket

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MRFLDLAATS AAVAATSGRR AKVELLAEAL RRLDPVEIAA GAGWLAGELR    50
QRQTGVGWAG LRDLPPPAAE PTLTVGAVDA AIDAIAAVHG SGSQARRRAL 100
VHSLYAAATA DEQRLLTGLF LGELRHGAQA GLLADAIARA AGVPVAAVRR 150
ALLLAGDLRE VAVAALAGGA AALAGFGLRV GRPLAPMLAQ SASSVDEALA 200
ATGTPAVVDV KLDGIRIQVH RSGSDIAVFT RSLDDITARV PEVVAAVRAL 250
PARELVLDGE AIGLDETGRP LPFQQTSSAA ARRGGSAGAR STGGPTAAAP 300
VAPAVRAAAA STGTTVLTPY FFDLLHLDGT DLIDAPGRER WAVLRGTVDA 350
GLLVGRMEVD EPQRAGEAFA AALDAGQEGV VVKAPDAPYE AGRRGAAWIK 400
VKPRHTLDLV VLAVEWGSGR RTGWLSNLHL GARDPRTGEF VMLGKTFKGL 450
TDDLLRWQTE RFLGLAVERG DWVVRVRPEQ VVEIAFDGVQ TSSRYPGGVA 500
LRFARVVRYR EDKSAAEADT IDTVRAIHAG RPPAAPSP 538
Length:538
Mass (Da):56,037
Last modified:June 28, 2011 - v1
Checksum:i6E3443C358FB2881
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002638 Genomic DNA. Translation: AEB46847.1.
RefSeqiYP_004407447.1. NC_015434.1.

Genome annotation databases

EnsemblBacteriaiAEB46847; AEB46847; VAB18032_28881.
GeneIDi10453626.
KEGGivma:VAB18032_28881.
PATRICi54478133. VBIVerMar92278_4913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002638 Genomic DNA. Translation: AEB46847.1 .
RefSeqi YP_004407447.1. NC_015434.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB46847 ; AEB46847 ; VAB18032_28881 .
GeneIDi 10453626.
KEGGi vma:VAB18032_28881.
PATRICi 54478133. VBIVerMar92278_4913.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci VMAR263358:GI1P-4863-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032."
    Roh H., Uguru G.C., Ko H.J., Kim S., Kim B.Y., Goodfellow M., Bull A.T., Kim K.H., Bibb M.J., Choi I.G., Stach J.E.
    J. Bacteriol. 193:3391-3392(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AB-18-032Imported.

Entry informationi

Entry nameiF4F695_VERMA
AccessioniPrimary (citable) accession number: F4F695
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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