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Protein

Probable DNA ligase

Gene

ligB

Organism
Verrucosispora maris (strain AB-18-032)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1
Active sitei211N6-AMP-lysine intermediateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei231ATPUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei322ATPUniRule annotation1
Binding sitei394ATPUniRule annotation1
Binding sitei400ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:VAB18032_28881Imported
OrganismiVerrucosispora maris (strain AB-18-032)Imported
Taxonomic identifieri263358 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeVerrucosispora
Proteomesi
  • UP000008308 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi263358.VAB18032_28881

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini320 – 434DNA_LIGASE_A3InterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F4F695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLDLAATS AAVAATSGRR AKVELLAEAL RRLDPVEIAA GAGWLAGELR
60 70 80 90 100
QRQTGVGWAG LRDLPPPAAE PTLTVGAVDA AIDAIAAVHG SGSQARRRAL
110 120 130 140 150
VHSLYAAATA DEQRLLTGLF LGELRHGAQA GLLADAIARA AGVPVAAVRR
160 170 180 190 200
ALLLAGDLRE VAVAALAGGA AALAGFGLRV GRPLAPMLAQ SASSVDEALA
210 220 230 240 250
ATGTPAVVDV KLDGIRIQVH RSGSDIAVFT RSLDDITARV PEVVAAVRAL
260 270 280 290 300
PARELVLDGE AIGLDETGRP LPFQQTSSAA ARRGGSAGAR STGGPTAAAP
310 320 330 340 350
VAPAVRAAAA STGTTVLTPY FFDLLHLDGT DLIDAPGRER WAVLRGTVDA
360 370 380 390 400
GLLVGRMEVD EPQRAGEAFA AALDAGQEGV VVKAPDAPYE AGRRGAAWIK
410 420 430 440 450
VKPRHTLDLV VLAVEWGSGR RTGWLSNLHL GARDPRTGEF VMLGKTFKGL
460 470 480 490 500
TDDLLRWQTE RFLGLAVERG DWVVRVRPEQ VVEIAFDGVQ TSSRYPGGVA
510 520 530
LRFARVVRYR EDKSAAEADT IDTVRAIHAG RPPAAPSP
Length:538
Mass (Da):56,037
Last modified:June 28, 2011 - v1
Checksum:i6E3443C358FB2881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002638 Genomic DNA Translation: AEB46847.1
RefSeqiWP_013735496.1, NC_015434.1

Genome annotation databases

EnsemblBacteriaiAEB46847; AEB46847; VAB18032_28881
KEGGivma:VAB18032_28881

Similar proteinsi

Entry informationi

Entry nameiF4F695_VERMA
AccessioniPrimary (citable) accession number: F4F695
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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