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F4EUL9 (F4EUL9_SELS3) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine--tRNA ligase HAMAP-Rule MF_02006
EC=6.1.1.1 HAMAP-Rule MF_02006
Alternative name(s):
Tyrosyl-tRNA synthetase HAMAP-Rule MF_02006
Gene names
Name:tyrS HAMAP-Rule MF_02006
ORF Names:Selsp_1084 EMBL AEC00044.1
OrganismSelenomonas sputigena (strain ATCC 35185 / DSM 20758 / VPI D19B-28) [Complete proteome] [HAMAP] EMBL AEC00044.1
Taxonomic identifier546271 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Negativicutes › Selenomonadales › Veillonellaceae › Selenomonas ›

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP-Rule MF_02006 SAAS SAAS002307

Catalytic activity

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP-Rule MF_02006 SAAS SAAS002307

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02006 SAAS SAAS002307

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02006 SAAS SAAS002307.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. HAMAP-Rule MF_02006

Contains 1 S4 RNA-binding domain. HAMAP-Rule MF_02006 SAAS SAAS002307

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain340 – 40566S4 RNA-binding By similarity HAMAP-Rule MF_02006
Motif40 – 4910"HIGH" region By similarity HAMAP-Rule MF_02006
Motif228 – 2325"KMSKS" region By similarity HAMAP-Rule MF_02006

Sites

Binding site351Tyrosine By similarity HAMAP-Rule MF_02006
Binding site1681Tyrosine By similarity HAMAP-Rule MF_02006
Binding site1721Tyrosine By similarity HAMAP-Rule MF_02006
Binding site2311ATP By similarity HAMAP-Rule MF_02006

Sequences

Sequence LengthMass (Da)Tools
F4EUL9 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: C3DDFFC04AA90455

FASTA40645,312
        10         20         30         40         50         60 
MANVFDVLKE RGFIAQCTDE EGVRELLGKE SVTFYTGFDP TADSLHVGHF LGLMAMSHMQ 

        70         80         90        100        110        120 
RAGHRPVCLV GGGTGTVGDP SGRTDMRRML TDEDIEHNCD CFKKQIARFI DFSEGKALMV 

       130        140        150        160        170        180 
NNGDWLRKLN YIELLREVGA HFTVNRMLSA EAYKTRWEKG LTFLEFNYMV MQAYDFLELS 

       190        200        210        220        230        240 
HRCGCKLQMG GDDQWSNIIA GVELIRRKEA KPAYGLTFTL LTKSDGQKMG KTAGGALWLD 

       250        260        270        280        290        300 
AEKTSPYDFY QYWRNIDDAD VEKCLALLTF LPMEEVRRLG ALRDAAINEA KTVLAYEVTK 

       310        320        330        340        350        360 
LVHGEAEAKK AKEGAEAMFG RGAASAELPT FTLTAEEMGA KLLDILAKNG VFSSKSEGRR 

       370        380        390        400 
LISQGGVTLN DARVTDADYR LQEEDFSDGT ALVKKGKKKH YRLVKA

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References

[1]"The complete genome of Selenomonas sputigena DSM 20758."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Schneider S., Klenk H.-P., Eisen J.A.
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35185 / DSM 20758 / VPI D19B-28.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002637 Genomic DNA. Translation: AEC00044.1.
RefSeqYP_004413503.1. NC_015437.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEC00044; AEC00044; Selsp_1084.
GeneID10497315.
KEGGssg:Selsp_1084.
PATRIC54551623. VBISelSpu203744_1102.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01866.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_02006. Tyr_tRNA_synth_type1.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024107. Tyr-tRNA-ligase_bac_1.
[Graphical view]
PANTHERPTHR11766. PTHR11766. 1 hit.
PfamPF01479. S4. 1 hit.
PF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01040. TRNASYNTHTYR.
SMARTSM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00234. tyrS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4EUL9_SELS3
AccessionPrimary (citable) accession number: F4EUL9
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 1, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info