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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus amyloliquefaciens LL3
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

Cofactori

thiamine diphosphateUniRule annotationSAAS annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-HAMAP
  2. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBAMY1001582:GL8C-2169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotationSAAS annotation (EC:1.2.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotationImported
ORF Names:LL3_02109Imported
OrganismiBacillus amyloliquefaciens LL3Imported
Taxonomic identifieri1001582 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000308: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

F4EM25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQNNMKQRM NWEDFYGPNL GYALELYDQY AEDPDSIDPD LKDMFDELGA
60 70 80 90 100
PPSQIKEASG TKEQGRVTAD LIQKIAAAVK LAEDIRTYGH LNASVNPLRK
110 120 130 140 150
DQKKSELFPL SEYGLTEEEM KAIPASVICK DAPANITNGL EAIQHLRNTY
160 170 180 190 200
KRTISFEFDH VHDFEERAWI TKMVESGELF RKNSPEKLSA VLERLTEVEG
210 220 230 240 250
FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKAGTT NVNIGMAHRG
260 270 280 290 300
RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSTGISYG WTGDVKYHLG
310 320 330 340 350
ADRQLQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQKGYPVQ
360 370 380 390 400
DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF
410 420 430 440 450
TTESDESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKRFN
460 470 480 490 500
KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKR IFAEKLVSEG
510 520 530 540 550
LISEEKAQNI EATVTKRIED AYKKVPAKKE DAVREIELPE PVSNGFPDVD
560 570 580 590 600
TAIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA
610 620 630 640 650
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG KEFVALHHLD
660 670 680 690 700
DCAASFAVHN SPLSEGSVLG FEYGYNVYSP ETLVMWEAQY GDFANAAQVY
710 720 730 740 750
FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRVER FLQLAAENNW
760 770 780 790 800
TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE
810 820 830 840 850
LSESRFKPVY EQSGLSHAYE KVTRVVLSSG KVSIDISDHF NKMEGDKDWL
860 870 880 890 900
HIARIEQLYP FPAKDAKELF AKLPNLQEIV WVQEEPQNMG AWSYISPYLT
910 920 930 940
EIAPKGVNVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN
Length:944
Mass (Da):106,265
Last modified:June 28, 2011 - v1
Checksum:i99F5CAAAB5117AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002634 Genomic DNA. Translation: AEB63646.1.
RefSeqiWP_014470298.1. NC_017190.1.
YP_005545874.1. NC_017190.1.

Genome annotation databases

EnsemblBacteriaiAEB63646; AEB63646; LL3_02109.
GeneIDi12203139.
KEGGibql:LL3_02109.
PATRICi54316465. VBIBacAmy188832_2077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002634 Genomic DNA. Translation: AEB63646.1.
RefSeqiWP_014470298.1. NC_017190.1.
YP_005545874.1. NC_017190.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB63646; AEB63646; LL3_02109.
GeneIDi12203139.
KEGGibql:LL3_02109.
PATRICi54316465. VBIBacAmy188832_2077.

Phylogenomic databases

KOiK00164.

Enzyme and pathway databases

BioCyciBAMY1001582:GL8C-2169-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid."
    Geng W., Cao M., Song C., Xie H., Liu L., Yang C., Feng J., Zhang W., Jin Y., Du Y., Wang S.
    J. Bacteriol. 193:3393-3394(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LL3Imported.

Entry informationi

Entry nameiF4EM25_BACAM
AccessioniPrimary (citable) accession number: F4EM25
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 4, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.