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F4EM25

- F4EM25_BACAM

UniProt

F4EM25 - F4EM25_BACAM

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, LL3_02109
Organism
Bacillus amyloliquefaciens LL3
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotations

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotations

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBAMY1001582:GL8C-2169-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhAUniRule annotationImported
ORF Names:LL3_02109Imported
OrganismiBacillus amyloliquefaciens LL3Imported
Taxonomic identifieri1001582 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000308: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

F4EM25-1 [UniParc]FASTAAdd to Basket

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MFQNNMKQRM NWEDFYGPNL GYALELYDQY AEDPDSIDPD LKDMFDELGA    50
PPSQIKEASG TKEQGRVTAD LIQKIAAAVK LAEDIRTYGH LNASVNPLRK 100
DQKKSELFPL SEYGLTEEEM KAIPASVICK DAPANITNGL EAIQHLRNTY 150
KRTISFEFDH VHDFEERAWI TKMVESGELF RKNSPEKLSA VLERLTEVEG 200
FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKAGTT NVNIGMAHRG 250
RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSTGISYG WTGDVKYHLG 300
ADRQLQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQKGYPVQ 350
DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF 400
TTESDESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKRFN 450
KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKR IFAEKLVSEG 500
LISEEKAQNI EATVTKRIED AYKKVPAKKE DAVREIELPE PVSNGFPDVD 550
TAIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA 600
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG KEFVALHHLD 650
DCAASFAVHN SPLSEGSVLG FEYGYNVYSP ETLVMWEAQY GDFANAAQVY 700
FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRVER FLQLAAENNW 750
TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE 800
LSESRFKPVY EQSGLSHAYE KVTRVVLSSG KVSIDISDHF NKMEGDKDWL 850
HIARIEQLYP FPAKDAKELF AKLPNLQEIV WVQEEPQNMG AWSYISPYLT 900
EIAPKGVNVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN 944
Length:944
Mass (Da):106,265
Last modified:June 28, 2011 - v1
Checksum:i99F5CAAAB5117AE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002634 Genomic DNA. Translation: AEB63646.1.
RefSeqiYP_005545874.1. NC_017190.1.

Genome annotation databases

EnsemblBacteriaiAEB63646; AEB63646; LL3_02109.
GeneIDi12203139.
KEGGibql:LL3_02109.
PATRICi54316465. VBIBacAmy188832_2077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002634 Genomic DNA. Translation: AEB63646.1 .
RefSeqi YP_005545874.1. NC_017190.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB63646 ; AEB63646 ; LL3_02109 .
GeneIDi 12203139.
KEGGi bql:LL3_02109.
PATRICi 54316465. VBIBacAmy188832_2077.

Phylogenomic databases

KOi K00164.

Enzyme and pathway databases

BioCyci BAMY1001582:GL8C-2169-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid."
    Geng W., Cao M., Song C., Xie H., Liu L., Yang C., Feng J., Zhang W., Jin Y., Du Y., Wang S.
    J. Bacteriol. 193:3393-3394(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LL3Imported.

Entry informationi

Entry nameiF4EM25_BACAM
AccessioniPrimary (citable) accession number: F4EM25
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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