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F4EM25

- F4EM25_BACAM

UniProt

F4EM25 - F4EM25_BACAM

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus amyloliquefaciens LL3
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotationSAAS annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBAMY1001582:GL8C-2169-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenaseUniRule annotation
    Gene namesi
    Name:odhAUniRule annotationImported
    ORF Names:LL3_02109Imported
    OrganismiBacillus amyloliquefaciens LL3Imported
    Taxonomic identifieri1001582 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000308: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    KOiK00164.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F4EM25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQNNMKQRM NWEDFYGPNL GYALELYDQY AEDPDSIDPD LKDMFDELGA    50
    PPSQIKEASG TKEQGRVTAD LIQKIAAAVK LAEDIRTYGH LNASVNPLRK 100
    DQKKSELFPL SEYGLTEEEM KAIPASVICK DAPANITNGL EAIQHLRNTY 150
    KRTISFEFDH VHDFEERAWI TKMVESGELF RKNSPEKLSA VLERLTEVEG 200
    FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKAGTT NVNIGMAHRG 250
    RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSTGISYG WTGDVKYHLG 300
    ADRQLQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQKGYPVQ 350
    DETKSLAILI HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF 400
    TTESDESRST KYASDLAKGY EIPIVHVNAD DPEACLSAVK FAVEYRKRFN 450
    KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD AVRKHPTVKR IFAEKLVSEG 500
    LISEEKAQNI EATVTKRIED AYKKVPAKKE DAVREIELPE PVSNGFPDVD 550
    TAIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA 600
    ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG KEFVALHHLD 650
    DCAASFAVHN SPLSEGSVLG FEYGYNVYSP ETLVMWEAQY GDFANAAQVY 700
    FDQFISAGRA KWGQKSGLVM LLPHGYEGQG PEHSSGRVER FLQLAAENNW 750
    TVANLTSAAQ YFHILRRQAK MLLREEIRPL VIMTPKSLLR NPNTVSEVQE 800
    LSESRFKPVY EQSGLSHAYE KVTRVVLSSG KVSIDISDHF NKMEGDKDWL 850
    HIARIEQLYP FPAKDAKELF AKLPNLQEIV WVQEEPQNMG AWSYISPYLT 900
    EIAPKGVNVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN 944
    Length:944
    Mass (Da):106,265
    Last modified:June 28, 2011 - v1
    Checksum:i99F5CAAAB5117AE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002634 Genomic DNA. Translation: AEB63646.1.
    RefSeqiYP_005545874.1. NC_017190.1.

    Genome annotation databases

    EnsemblBacteriaiAEB63646; AEB63646; LL3_02109.
    GeneIDi12203139.
    KEGGibql:LL3_02109.
    PATRICi54316465. VBIBacAmy188832_2077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002634 Genomic DNA. Translation: AEB63646.1 .
    RefSeqi YP_005545874.1. NC_017190.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEB63646 ; AEB63646 ; LL3_02109 .
    GeneIDi 12203139.
    KEGGi bql:LL3_02109.
    PATRICi 54316465. VBIBacAmy188832_2077.

    Phylogenomic databases

    KOi K00164.

    Enzyme and pathway databases

    BioCyci BAMY1001582:GL8C-2169-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid."
      Geng W., Cao M., Song C., Xie H., Liu L., Yang C., Feng J., Zhang W., Jin Y., Du Y., Wang S.
      J. Bacteriol. 193:3393-3394(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LL3Imported.

    Entry informationi

    Entry nameiF4EM25_BACAM
    AccessioniPrimary (citable) accession number: F4EM25
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3