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F4EM25 (F4EM25_BACAM) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169

EC=1.2.4.2 HAMAP-Rule MF_01169
Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169
Gene names
Name:odhA HAMAP-Rule MF_01169 EMBL AEB63646.1
ORF Names:LL3_02109 EMBL AEB63646.1
OrganismBacillus amyloliquefaciens LL3 [Complete proteome] EMBL AEB63646.1
Taxonomic identifier1001582 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169 SAAS SAAS023784

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Sequences

Sequence LengthMass (Da)Tools
F4EM25 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 99F5CAAAB5117AE8

FASTA944106,265
        10         20         30         40         50         60 
MFQNNMKQRM NWEDFYGPNL GYALELYDQY AEDPDSIDPD LKDMFDELGA PPSQIKEASG 

        70         80         90        100        110        120 
TKEQGRVTAD LIQKIAAAVK LAEDIRTYGH LNASVNPLRK DQKKSELFPL SEYGLTEEEM 

       130        140        150        160        170        180 
KAIPASVICK DAPANITNGL EAIQHLRNTY KRTISFEFDH VHDFEERAWI TKMVESGELF 

       190        200        210        220        230        240 
RKNSPEKLSA VLERLTEVEG FEQFLHRTFV GQKRFSIEGL DALVPVLDDI IAQSVKAGTT 

       250        260        270        280        290        300 
NVNIGMAHRG RLNVLAHVLG KPYEIIFSEF QHAPNKDLVP SEGSTGISYG WTGDVKYHLG 

       310        320        330        340        350        360 
ADRQLQDAET KSARITLANN PSHLEFINPI VEGSTRAAQE TRTQKGYPVQ DETKSLAILI 

       370        380        390        400        410        420 
HGDAAFPGEG IVAETLNLSS LKGYQVGGAI HIIANNMIGF TTESDESRST KYASDLAKGY 

       430        440        450        460        470        480 
EIPIVHVNAD DPEACLSAVK FAVEYRKRFN KDFLIDLIGY RRYGHNEMDE PSTTQPMLYD 

       490        500        510        520        530        540 
AVRKHPTVKR IFAEKLVSEG LISEEKAQNI EATVTKRIED AYKKVPAKKE DAVREIELPE 

       550        560        570        580        590        600 
PVSNGFPDVD TAIDFDVLRK LNGELINWPE SFNVFGKLKR ILERRAKAFD DDRKVEWSLA 

       610        620        630        640        650        660 
ESLAFASILK DGTPIRLTGQ DSERGTFAQR NLVLHDSETG KEFVALHHLD DCAASFAVHN 

       670        680        690        700        710        720 
SPLSEGSVLG FEYGYNVYSP ETLVMWEAQY GDFANAAQVY FDQFISAGRA KWGQKSGLVM 

       730        740        750        760        770        780 
LLPHGYEGQG PEHSSGRVER FLQLAAENNW TVANLTSAAQ YFHILRRQAK MLLREEIRPL 

       790        800        810        820        830        840 
VIMTPKSLLR NPNTVSEVQE LSESRFKPVY EQSGLSHAYE KVTRVVLSSG KVSIDISDHF 

       850        860        870        880        890        900 
NKMEGDKDWL HIARIEQLYP FPAKDAKELF AKLPNLQEIV WVQEEPQNMG AWSYISPYLT 

       910        920        930        940 
EIAPKGVNVQ YIGRRRRSSP AEGDPTVHKK EQERIVSDSL TRKN 

« Hide

References

[1]"Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid."
Geng W., Cao M., Song C., Xie H., Liu L., Yang C., Feng J., Zhang W., Jin Y., Du Y., Wang S.
J. Bacteriol. 193:3393-3394(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: LL3 EMBL AEB63646.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002634 Genomic DNA. Translation: AEB63646.1.
RefSeqYP_005545874.1. NC_017190.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEB63646; AEB63646; LL3_02109.
GeneID12203139.
KEGGbql:LL3_02109.
PATRIC54316465. VBIBacAmy188832_2077.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00164.

Enzyme and pathway databases

BioCycBAMY1001582:GL8C-2169-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF4EM25_BACAM
AccessionPrimary (citable) accession number: F4EM25
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)