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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacillus amyloliquefaciens LL3
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBAMY1001582:GL8C-3065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:LL3_03001Imported
OrganismiBacillus amyloliquefaciens LL3Imported
Taxonomic identifieri1001582 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000308: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4EIX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGEKITVS NGVLNVPNNP IIPFIEGDGT GPDIWNAASK VLEAAVEKAY
60 70 80 90 100
KGEKKITWKE VYAGEKAYNK TGEWLPAQTL EDIREYFIAI KGPLTTPVGG
110 120 130 140 150
GIRSLNVALR QELDLFTCLR PVRYFTGVPS PVKRPEDTDM VIFRENTEDI
160 170 180 190 200
YAGIEYAKGS EEVEKLISFL QNEMGVNKIR FPETSGIGIK PVSEEGTSRL
210 220 230 240 250
VRAAIEYAIE NGRKSVTLVH KGNIMKFTEG AFKNWGYELA EREYGDKVFT
260 270 280 290 300
WAEYDRIVEK DGKEAADKAQ SEAEAAGKII VKDSIADIFL QQILTRPSEF
310 320 330 340 350
DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYETGHAI FEATHGTAPK
360 370 380 390 400
YAGLDKVNPS SVILSGVLLL EHLNWNEAAD LIIKSMEKTI ASKVVTYDFA
410 420
RLMDGATEVK CSEFGEELIK NMD
Length:423
Mass (Da):46,506
Last modified:June 28, 2011 - v1
Checksum:i39F4AAA75CAA3C4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002634 Genomic DNA. Translation: AEB64532.1.
RefSeqiWP_013353156.1. NC_017190.1.
YP_005546760.1. NC_017190.1.

Genome annotation databases

EnsemblBacteriaiAEB64532; AEB64532; LL3_03001.
GeneIDi12202087.
KEGGibql:LL3_03001.
PATRICi54318218. VBIBacAmy188832_2943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002634 Genomic DNA. Translation: AEB64532.1.
RefSeqiWP_013353156.1. NC_017190.1.
YP_005546760.1. NC_017190.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB64532; AEB64532; LL3_03001.
GeneIDi12202087.
KEGGibql:LL3_03001.
PATRICi54318218. VBIBacAmy188832_2943.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciBAMY1001582:GL8C-3065-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid."
    Geng W., Cao M., Song C., Xie H., Liu L., Yang C., Feng J., Zhang W., Jin Y., Du Y., Wang S.
    J. Bacteriol. 193:3393-3394(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LL3Imported.

Entry informationi

Entry nameiF4EIX8_BACAM
AccessioniPrimary (citable) accession number: F4EIX8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.