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F4EFD7 (F4EFD7_STRSU) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] HAMAP-Rule MF_00344
EC=6.3.5.2 HAMAP-Rule MF_00344
Alternative name(s):
GMP synthetase HAMAP-Rule MF_00344
Glutamine amidotransferase HAMAP-Rule MF_00344
Gene names
Name:guaA HAMAP-Rule MF_00344 EMBL AEB81429.1
ORF Names:SSUST3_0996 EMBL AEB81429.1
OrganismStreptococcus suis
Taxonomic identifier1307 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP-Rule MF_00344 SAAS SAAS022955

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP-Rule MF_00344 SAAS SAAS022955

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence similarities

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00344 SAAS SAAS022955

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain8 – 201194Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00344
Domain202 – 391190GMPS ATP-PPase By similarity HAMAP-Rule MF_00344
Nucleotide binding229 – 2357ATP By similarity HAMAP-Rule MF_00344

Sites

Active site851Nucleophile By similarity HAMAP-Rule MF_00344
Active site1751 By similarity HAMAP-Rule MF_00344
Active site1771 By similarity HAMAP-Rule MF_00344

Sequences

Sequence LengthMass (Da)Tools
F4EFD7 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 223A0ED2834EB263

FASTA51657,136
        10         20         30         40         50         60 
MTKQDVQKII VLDYGSQYNQ LISRRIREFG VFSELKNHKI TAEEVRAINP IGIVLSGGPN 

        70         80         90        100        110        120 
SVYAENAFDI DPEIFELGIP ILGICYGMQL ITHKLVGKVV PAGEAGNREY GQSNLQLKTE 

       130        140        150        160        170        180 
SALFAGTPEE QLVLMSHGDA VTEIPADFHL VGLSADCPYA AIENTERRIY GIQFHPEVRH 

       190        200        210        220        230        240 
SVYGNDILKN FAFGICGAKG DWTMENFIET EIEKIRQTVG DKKVLLGLSG GVDSSVVGVL 

       250        260        270        280        290        300 
LQRAIGDQLT CIFVDHGLLR KNEGDQVMEM LGGKFGLNII RVDAAKRFLD LLAGVSDPEK 

       310        320        330        340        350        360 
KRKIIGNEFV YVFDDEASKL TDVEFLAQGT LYTDIIESGT DTAETIKSHH NVGGLPEDMQ 

       370        380        390        400        410        420 
FKLIEPLNTL FKDEVRALGT ALGMPDEVVW RQPFPGPGLA IRVMGEITEE KLQTVRESDA 

       430        440        450        460        470        480 
ILREEIAKAG LDRDVWQYFT VNTGVRSVGV MGDGRTYDYT IAIRAITSVD GMTADFAKLP 

       490        500        510 
WDVLQKISVR IVNEVDHVNR IVYDITSKPP ATVEWE

« Hide

References

[1]"Complete Genome Sequence of Streptococcus suis Serotype 3 Strain ST3."
Hu P., Yang M., Zhang A., Wu J., Chen B., Hua Y., Yu J., Chen H., Xiao J., Jin M.
J. Bacteriol. 193:3428-3429(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ST3 EMBL AEB81429.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002633 Genomic DNA. Translation: AEB81429.1.
RefSeqYP_004401615.1. NC_015433.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEB81429; AEB81429; SSUST3_0996.
GeneID10491165.
KEGGsst:SSUST3_0996.
PATRIC54543114. VBIStrSui186933_0975.

Phylogenomic databases

KOK01951.

Enzyme and pathway databases

UniPathwayUPA00189; UER00296.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00344. GMP_synthase.
InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4EFD7_STRSU
AccessionPrimary (citable) accession number: F4EFD7
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 3, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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