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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Pseudomonas mendocina (strain NK-01)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotationSAAS annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotationSAAS annotation

Cofactori

FMNUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandFlavoprotein, FMNUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.-.-UniRule annotationSAAS annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:MDS_3940Imported
OrganismiPseudomonas mendocina (strain NK-01)Imported
Taxonomic identifieri1001585 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000008306 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotationSAAS annotation; Peripheral membrane protein UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotationSAAS annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi1001585.MDS_3940.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 375FMN_dhInterPro annotationAdd BLAST363

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DMF. Bacteria.
COG1304. LUCA.
KOiK00101.
OMAiDTPGFFQ.

Family and domain databases

CDDicd02809. alpha_hydroxyacid_oxid_FMN. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. LldD.
PfamiView protein in Pfam
PF01070. FMN_dh. 1 hit.
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiView protein in PROSITE
PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F4DVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISASTDYR AAAQRKLPPF LFHYADGGAY AEHTLRRNVA DLSDIELRQR
60 70 80 90 100
VLKNMSELDL STELFGEKMS MPVGLAPVGL TGMFARRGEV QAAKAAAAKG
110 120 130 140 150
IPFTLSTVSV CPIEEVAPAI DRPMWFQLYV LKDRGFMKNA LERAKAAGCS
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGPNAAMR RMLQAMTHPQ WAWDVGLLGK
210 220 230 240 250
PHDLGNISAY RGNPTGLADY IGWLGANFDP SISWKDLEWI RDFWDGPMVI
260 270 280 290 300
KGILDPEDAR DAVTFGADGI IVSNHGGRQL DGVLSSARAL PAIADAVKGD
310 320 330 340 350
LKILADSGIR TGLDVVRMIA LGADTVLLGR AFLYALAAAG GAGVSNLLDL
360 370
IEKEMRVAMV LTGAKSIAEV TSDLLVKER
Length:379
Mass (Da):40,812
Last modified:June 28, 2011 - v1
Checksum:iBB06D100B7823F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002620 Genomic DNA. Translation: AEB59971.1.
RefSeqiWP_013717018.1. NC_015410.1.

Genome annotation databases

EnsemblBacteriaiAEB59971; AEB59971; MDS_3940.
KEGGipmk:MDS_3940.

Similar proteinsi

Entry informationi

Entry nameiF4DVY1_PSEMN
AccessioniPrimary (citable) accession number: F4DVY1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported