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Protein

Alanine racemase

Gene

Psed_5369

Organism
Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Psed_5369)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Active sitei292Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei342Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Psed_5369Imported
OrganismiPseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)Imported
Taxonomic identifieri675635 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPseudonocardialesPseudonocardiaceaePseudonocardia
Proteomesi
  • UP000007809 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi675635.Psed_5369.

Structurei

3D structure databases

ProteinModelPortaliF4CW85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 404Ala_racemase_CInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F4CW85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGARPDGV VGGCDDAGVA QPSMSDRGPR AELVVDLAAV RHNVGLLSRG
60 70 80 90 100
AAASGAATMA VVKSDGYGHG AADVARAALQ AGASWLGVCT LDEALALRAD
110 120 130 140 150
GIEAPVLSWL HLPHEDFAPA VAAGVDLSVS SHGHLDAVLA GARAVDRPAR
160 170 180 190 200
LHLKIDTGLS RNGCPEDDWP DLVDAAAKAA AAGRCEVVAV WSHLAVADVA
210 220 230 240 250
RHPVTEAQAA RFDAAWRVAR DRGLTPIRHL ANSAATMTRP DLHYDLVRPG
260 270 280 290 300
IAVYGLDPLG RPVAESPLRP AMTVRGRVVL VKQVRAGEGV SYGHEFTTPR
310 320 330 340 350
DTVLALVPIG YGDGVPRRMN FGGRMRVWLA GRSRPVVGRV CMDQVVVDCG
360 370 380 390 400
PDGGAEVREG DVAVLFGPGD DGAPTAQEWA DELGTIHYEV VTGVQGRRMT
410
RTVVGREAGP GTEQEGAAW
Length:419
Mass (Da):43,622
Last modified:June 28, 2011 - v1
Checksum:iED01A9FFF64D6AE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002593 Genomic DNA. Translation: AEA27503.1.

Genome annotation databases

EnsemblBacteriaiAEA27503; AEA27503; Psed_5369.
KEGGipdx:Psed_5369.

Similar proteinsi

Entry informationi

Entry nameiF4CW85_PSEUX
AccessioniPrimary (citable) accession number: F4CW85
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported