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Protein

Alanine racemase

Gene

Psed_5369

Organism
Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Active sitei292 – 2921Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei342 – 3421Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPDIO675635:GHMF-5419-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Psed_5369Imported
OrganismiPseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190)Imported
Taxonomic identifieri675635 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaePseudonocardia
ProteomesiUP000007809 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF4CW85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiITMDQLM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4CW85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGARPDGV VGGCDDAGVA QPSMSDRGPR AELVVDLAAV RHNVGLLSRG
60 70 80 90 100
AAASGAATMA VVKSDGYGHG AADVARAALQ AGASWLGVCT LDEALALRAD
110 120 130 140 150
GIEAPVLSWL HLPHEDFAPA VAAGVDLSVS SHGHLDAVLA GARAVDRPAR
160 170 180 190 200
LHLKIDTGLS RNGCPEDDWP DLVDAAAKAA AAGRCEVVAV WSHLAVADVA
210 220 230 240 250
RHPVTEAQAA RFDAAWRVAR DRGLTPIRHL ANSAATMTRP DLHYDLVRPG
260 270 280 290 300
IAVYGLDPLG RPVAESPLRP AMTVRGRVVL VKQVRAGEGV SYGHEFTTPR
310 320 330 340 350
DTVLALVPIG YGDGVPRRMN FGGRMRVWLA GRSRPVVGRV CMDQVVVDCG
360 370 380 390 400
PDGGAEVREG DVAVLFGPGD DGAPTAQEWA DELGTIHYEV VTGVQGRRMT
410
RTVVGREAGP GTEQEGAAW
Length:419
Mass (Da):43,622
Last modified:June 28, 2011 - v1
Checksum:iED01A9FFF64D6AE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002593 Genomic DNA. Translation: AEA27503.1.
RefSeqiWP_013677408.1. NC_015312.1.
YP_004335356.1. NC_015312.1.

Genome annotation databases

EnsemblBacteriaiAEA27503; AEA27503; Psed_5369.
KEGGipdx:Psed_5369.
PATRICi54402366. VBIPseDio141225_5443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002593 Genomic DNA. Translation: AEA27503.1.
RefSeqiWP_013677408.1. NC_015312.1.
YP_004335356.1. NC_015312.1.

3D structure databases

ProteinModelPortaliF4CW85.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEA27503; AEA27503; Psed_5369.
KEGGipdx:Psed_5369.
PATRICi54402366. VBIPseDio141225_5443.

Phylogenomic databases

KOiK01775.
OMAiITMDQLM.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPDIO675635:GHMF-5419-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 55486 / DSM 44775 / JCM 13855 / CB1190Imported.

Entry informationi

Entry nameiF4CW85_PSEUX
AccessioniPrimary (citable) accession number: F4CW85
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 29, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.