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F4CLU6 (F4CLU6_PSEUX) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1 HAMAP-Rule MF_00223
EC=3.5.4.16 HAMAP-Rule MF_00223
Alternative name(s):
GTP cyclohydrolase I HAMAP-Rule MF_00223
Gene names
Name:folE HAMAP-Rule MF_00223
Ordered Locus Names:Psed_6126 EMBL AEA28228.1
OrganismPseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 / CB1190) [Complete proteome] [HAMAP] EMBL AEA28228.1
Taxonomic identifier675635 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Pseudonocardia ›

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223 SAAS SAAS001474

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. SAAS SAAS001474 HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family. HAMAP-Rule MF_00223

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding931Zinc By similarity HAMAP-Rule MF_00223
Metal binding961Zinc By similarity HAMAP-Rule MF_00223
Metal binding1661Zinc By similarity HAMAP-Rule MF_00223

Sequences

Sequence LengthMass (Da)Tools
F4CLU6 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 05E5D3CFC31C5C44

FASTA20522,272
        10         20         30         40         50         60 
MSSASAAAPT SSVNGHRGVD RARAEAAVRE LLIAIGEDPD REGLRDTPAR VARAYEEIFA 

        70         80         90        100        110        120 
GLYTDADAVL DRTFDEQHQE LILVKDIPMF STCEHHLVPF HGVAHVGYIP NVTGRVTGLS 

       130        140        150        160        170        180 
KIARVVENYA RRPQVQERLT GQVADALVRK LEPRGVIVVI DAEHLCMAMR GVRKPGSRTT 

       190        200 
TSAVRGLFST SSTSRAEAMS LIRSG

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References

[1]"Genome sequence of the 1,4-dioxane-degrading Pseudonocardia dioxanivorans strain CB1190."
Sales C.M., Mahendra S., Grostern A., Parales R.E., Goodwin L.A., Woyke T., Nolan M., Lapidus A., Chertkov O., Ovchinnikova G., Sczyrba A., Alvarez-Cohen L.
J. Bacteriol. 193:4549-4550(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 55486 / DSM 44775 / JCM 13855 / CB1190.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002593 Genomic DNA. Translation: AEA28228.1.
RefSeqYP_004336081.1. NC_015312.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEA28228; AEA28228; Psed_6126.
GeneID10367981.
KEGGpdx:Psed_6126.
PATRIC54403896. VBIPseDio141225_6202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01495.

Enzyme and pathway databases

BioCycPDIO675635:GHMF-6180-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR020602. GTP_CycHdrlase_I/CN_OxRdtase.
IPR018234. GTP_CycHdrlase_I_CS.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4CLU6_PSEUX
AccessionPrimary (citable) accession number: F4CLU6
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 29, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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