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F4CD21

- F4CD21_SPHS2

UniProt

F4CD21 - F4CD21_SPHS2

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Protein
ATP-dependent 6-phosphofructokinase
Gene
pfkA, Sph21_1062
Organism
Sphingobacterium sp. (strain 21)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi106 – 1061Magnesium; catalytic By similarityUniRule annotation
Active sitei131 – 1311Proton acceptor By similarityUniRule annotation
Binding sitei158 – 1581Allosteric activator ADP By similarityUniRule annotation
Binding sitei166 – 1661Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei225 – 2251Substrate By similarityUniRule annotation
Binding sitei249 – 2491Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 762ATP By similarityUniRule annotation
Nucleotide bindingi105 – 1084ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP743722:GH04-1077-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Sph21_1062Imported
OrganismiSphingobacterium sp. (strain 21)Imported
Taxonomic identifieri743722 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesSphingobacteriaceaeSphingobacterium
ProteomesiUP000007808: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 285Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni129 – 1313Substrate binding By similarityUniRule annotation
Regioni173 – 1753Substrate binding By similarityUniRule annotation
Regioni189 – 1913Allosteric activator ADP binding By similarityUniRule annotation
Regioni216 – 2183Allosteric activator ADP binding By similarityUniRule annotation
Regioni255 – 2584Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00850.
OMAiMELREGH.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4CD21-1 [UniParc]FASTAAdd to Basket

« Hide

MSTIKNIAVF TSGGDSPGMN AAIRAVVRTS LHYNLNVFGI QRGYDGMVNG    50
DIFPMDAKSV ANIIQRGGTI LKTARSKEFR TVEGRQQAYE QIRKFQIDGL 100
VAIGGDGTFT GAAKFIEEHD IPVMGLPGTI DNDLAGTDFT IGYDTAINTV 150
ISAVDKIRDT AESHDRLFII EVMGRDSGLI ALRSGIGTGA EAILIPESAT 200
NSKALLEKLA HGRKDKSSKI VLVAEGDEEG GAFAIAELVK KHFPNYDTRV 250
SILGHIQRGG SPTCMDRVLA SRLGVAAVEA LLAGRKGEMA GVINGDIAFT 300
PFNKAIKHID SLTPSLLKIV DILS 324
Length:324
Mass (Da):34,525
Last modified:June 28, 2011 - v1
Checksum:iE270CCCE1B5FD1D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002584 Genomic DNA. Translation: ADZ77632.1.
RefSeqiWP_013664360.1. NC_015277.1.
YP_004316302.1. NC_015277.1.

Genome annotation databases

EnsemblBacteriaiADZ77632; ADZ77632; Sph21_1062.
GeneIDi10346804.
KEGGishg:Sph21_1062.
PATRICi47235888. VBISphSp165585_1138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002584 Genomic DNA. Translation: ADZ77632.1 .
RefSeqi WP_013664360.1. NC_015277.1.
YP_004316302.1. NC_015277.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADZ77632 ; ADZ77632 ; Sph21_1062 .
GeneIDi 10346804.
KEGGi shg:Sph21_1062.
PATRICi 47235888. VBISphSp165585_1138.

Phylogenomic databases

KOi K00850.
OMAi MELREGH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci SSP743722:GH04-1077-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Sphingobacterium sp. 21."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Siebers A.K., Allgaier M.
    , Thelen M.P., Hugenholtz P., Woyke T.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 21.

Entry informationi

Entry nameiF4CD21_SPHS2
AccessioniPrimary (citable) accession number: F4CD21
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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