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F4C2Y7 (F4C2Y7_SPHS2) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_00079
Short name=ATP-PRT HAMAP-Rule MF_00079
Short name=ATP-PRTase HAMAP-Rule MF_00079
EC=2.4.2.17 HAMAP-Rule MF_00079
Gene names
Name:hisG HAMAP-Rule MF_00079
Ordered Locus Names:Sph21_5142 EMBL ADZ81631.1
OrganismSphingobacterium sp. (strain 21) [Complete proteome] [HAMAP] EMBL ADZ81631.1
Taxonomic identifier743722 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Sphingobacteriia › Sphingobacteriales › Sphingobacteriaceae › Sphingobacterium

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00079 SAAS SAAS018198

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP-Rule MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_00079 SAAS SAAS018198

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP-Rule MF_00079

Sequences

Sequence LengthMass (Da)Tools
F4C2Y7 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 047ADDAD54DF1F3E

FASTA28330,978
        10         20         30         40         50         60 
MSSLKIAIQK SGRLNEKSVE LLKNCGLTFE NYKSSLISSV SNFPLEILFL RDDDIPEYVQ 

        70         80         90        100        110        120 
DGIADLGIVG ENVISETEVN VHFLQRLGFG KCTLKIAIPN ESELVQINDL EGRAIATSYP 

       130        140        150        160        170        180 
NILKKYLSDN QINATIRTIS GSVEISPGLG LSDAICDIVS TGGTLKSNGL KPFADVMSSE 

       190        200        210        220        230        240 
AILIGKNGIE KEEAVKELMQ RIQSVLKAKE TKYVVLNVKR ENLQIIVDLL PGVKSPTVVP 

       250        260        270        280 
LAEEGWVAVH TAIQERDFWE KINKLKAAGA QGIVVMPIEK IIM

« Hide

References

[1]"Complete sequence of Sphingobacterium sp. 21."
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Siebers A.K., Allgaier M. expand/collapse author list , Thelen M.P., Hugenholtz P., Woyke T.
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 21.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002584 Genomic DNA. Translation: ADZ81631.1.
RefSeqYP_004320301.1. NC_015277.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADZ81631; ADZ81631; Sph21_5142.
GeneID10350930.
KEGGshg:Sph21_5142.
PATRIC47244644. VBISphSp165585_5451.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00765.
OMAVATEFPN.

Enzyme and pathway databases

UniPathwayUPA00031; UER00006.

Family and domain databases

Gene3D3.30.70.120. 1 hit.
HAMAPMF_00079. HisG_Long.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4C2Y7_SPHS2
AccessionPrimary (citable) accession number: F4C2Y7
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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