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F4BT36

- HPRT_METCG

UniProt

F4BT36 - HPRT_METCG

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Protein
Hypoxanthine/guanine phosphoribosyltransferase
Gene
hpt, MCON_2988
Organism
Methanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6) (Methanothrix concilii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMCON990316:GHHN-2463-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:MCON_2988
OrganismiMethanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6) (Methanothrix concilii)
Taxonomic identifieri990316 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
ProteomesiUP000007807: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation
PRO_0000415477Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF4BT36.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00759.
OMAiMIAIINA.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4BT36-1 [UniParc]FASTAAdd to Basket

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MLERLKKSLL EAPVFKRGEY DYFIHPITDG VPEIRPDLIR EVTANIVRIA    50
NLDVDKIVTV EAMGIPIGIV LSILCDIPLV IIRKRKYGLP NEVEISQVTG 100
YSRSQLYLNG INRGDRVIVV DDVISTGGTL QATLDSMELA GAEVMDTVIV 150
VERGNGAELL RSKGYNLKTM VRVKVEGGRV SEVEPGISK 189
Length:189
Mass (Da):20,817
Last modified:June 28, 2011 - v1
Checksum:i9521B804266A6D86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002565 Genomic DNA. Translation: AEB69325.1.
RefSeqiWP_013720346.1. NC_015416.1.
YP_004385143.1. NC_015416.1.

Genome annotation databases

EnsemblBacteriaiAEB69325; AEB69325; MCON_2988.
GeneIDi10462281.
KEGGimcj:MCON_2988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002565 Genomic DNA. Translation: AEB69325.1 .
RefSeqi WP_013720346.1. NC_015416.1.
YP_004385143.1. NC_015416.1.

3D structure databases

ProteinModelPortali F4BT36.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB69325 ; AEB69325 ; MCON_2988 .
GeneIDi 10462281.
KEGGi mcj:MCON_2988.

Phylogenomic databases

KOi K00759.
OMAi MIAIINA.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MCON990316:GHHN-2463-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Methanosaeta concilii, a specialist in aceticlastic methanogenesis."
    Barber R.D., Zhang L., Harnack M., Olson M.V., Kaul R., Ingram-Smith C., Smith K.S.
    J. Bacteriol. 193:3668-3669(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6.

Entry informationi

Entry nameiHPRT_METCG
AccessioniPrimary (citable) accession number: F4BT36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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