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F4BM32

- F4BM32_CARS1

UniProt

F4BM32 - F4BM32_CARS1

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Protein

Thymidine kinase

Gene
tdk, CAR_c17080
Organism
Carnobacterium sp. (strain 17-4)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCSP208596:GHHT-1708-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:CAR_c17080Imported
OrganismiCarnobacterium sp. (strain 17-4)Imported
Taxonomic identifieri208596 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesCarnobacteriaceaeCarnobacterium
ProteomesiUP000008304: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4BM32-1 [UniParc]FASTAAdd to Basket

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MAQLFFKYGA MNSGKTIEIL KVAYNYEEQN KPVAIMTSGL DDRDEIGVVS    50
SRIGLRREGI AIFEETNVFE TINALNYVPA CVLIDESQFL KKEHVLQLAH 100
IVDELDIPVM AFGLKNDFKN ELFEGSEYLL LYADKIEEMK TICWYCHKKA 150
TMNMRMIDGK PVYAGAQIQI GGNESYFPVC RKHYFNPLLK DDL 193
Length:193
Mass (Da):22,108
Last modified:June 28, 2011 - v1
Checksum:i2E38258BDC0CB154
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002563 Genomic DNA. Translation: AEB30366.1.
RefSeqiWP_013711308.1. NC_015391.1.
YP_004375382.1. NC_015391.1.

Genome annotation databases

EnsemblBacteriaiAEB30366; AEB30366; CAR_c17080.
GeneIDi10441828.
KEGGicrn:CAR_c17080.
PATRICi54450944. VBICarSp108130_1681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002563 Genomic DNA. Translation: AEB30366.1 .
RefSeqi WP_013711308.1. NC_015391.1.
YP_004375382.1. NC_015391.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEB30366 ; AEB30366 ; CAR_c17080 .
GeneIDi 10441828.
KEGGi crn:CAR_c17080.
PATRICi 54450944. VBICarSp108130_1681.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci CSP208596:GHHT-1708-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Carnobacterium sp. 17-4."
    Voget S., Klippel B., Daniel R., Antranikian G.
    J. Bacteriol. 193:3403-3404(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17-4Imported.

Entry informationi

Entry nameiF4BM32_CARS1
AccessioniPrimary (citable) accession number: F4BM32
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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