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Protein

Glutaminase

Gene

glsA

Organism
Francisella cf. novicida (strain 3523)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei158SubstrateUniRule annotation1
Binding sitei207SubstrateUniRule annotation1
Binding sitei253SubstrateUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Binding sitei286SubstrateUniRule annotation1
Binding sitei338SubstrateUniRule annotation1
Binding sitei356Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciFCF676032:G12WU-157-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotationSAAS annotation (EC:3.5.1.2UniRule annotationSAAS annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:FN3523_0156Imported
OrganismiFrancisella cf. novicida (strain 3523)Imported
Taxonomic identifieri676032 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000008303 Componenti: Chromosome

PTM / Processingi

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi676032.FN3523_0156.

Structurei

3D structure databases

ProteinModelPortaliF4BIL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini423 – 514ANK_REP_REGIONInterPro annotationAdd BLAST92
Repeati456 – 488ANKPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotationSAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
KOiK01425.
OMAiQCCSMEA.
OrthoDBiPOG091H02PU.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF04960. Glutaminase. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 2 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

F4BIL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKLIRAGS TGKDYYTNIF NAICDKDGFL TKIDILAILD DAGIASDDPR
60 70 80 90 100
TTKLRAEINK LTVIDKIDFK KFREMTSDST GIIEKAVNKG FIIPNFKDFR
110 120 130 140 150
KEIEKIYEET KKNVSGKNAT YIPQLARVDS ELFAVAFCSV DGQMITLGDF
160 170 180 190 200
EHPYCVQSTA KPITYCIATE ENGEDKVHKH VGREPSGITF NAIALNKYDR
210 220 230 240 250
PHNPMINSGA IMMCSLIKPE WNLADRFEYI TNVWENLAGG ETIGFDNAVY
260 270 280 290 300
HSEKETANRN YALAYFMKEV GAFPQNTNID TSLDFYFQTC SIQVNAKKMS
310 320 330 340 350
KIMSSIANGG ICPFTHKKIF SPTTIRNCLS MMYSCGMYDF SGEYAFSVGL
360 370 380 390 400
PAKSGVSGAL AIAIPNVGGF AIFSPRLDNN HNSVRGVEFS KRLVEKFSFH
410 420 430 440 450
NYDHIAHCDK INPVEGRGTI DSNLTLELIW AASNGDLSEI KRAVALGVDI
460 470 480 490 500
SKGDYDKRTA LHLAAAEGHE DIVKYLIRKG ANPNAKDRWN RTPLEDAIAN
510
NHHHIARLLE KVSS
Length:514
Mass (Da):57,257
Last modified:June 28, 2011 - v1
Checksum:i90E01AB0E190D997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002558 Genomic DNA. Translation: AEB28013.1.
RefSeqiWP_014547492.1. NC_017449.1.

Genome annotation databases

EnsemblBacteriaiAEB28013; AEB28013; FN3523_0156.
KEGGifcn:FN3523_0156.
PATRICifig|676032.3.peg.158.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF4BIL9_FRACN
AccessioniPrimary (citable) accession number: F4BIL9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported