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Protein

Superoxide dismutase [Cu-Zn]

Gene

FNFX1_0398

Organism
Francisella cf. novicida (strain Fx1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciFNOV984129:GLDD-402-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:FNFX1_0398Imported
OrganismiFrancisella cf. novicida (strain Fx1)Imported
Taxonomic identifieri984129 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000008302: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

KOiK04565.
OMAiMAAGGHW.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4BDK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAFYKLCGM SMLSLVLADC TFLSANKPYD RDHDGELIVH MKDVNTHKEV
60 70 80 90 100
GTITISPYIH DGNQEGMLIT PHLYNLPANT THGMHIHINP SCEDNGMAAG
110 120 130 140 150
GHWDPDNTQK HLGPYNDNGH KGDLPVLVVN ADGTATEPVV APKLNSLEEL
160 170 180
AGHSLMLHAG GDNYSDKPQP LGGGGARMWC GVIAD
Length:185
Mass (Da):19,905
Last modified:June 28, 2011 - v1
Checksum:i779C96E8FB50043B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002557 Genomic DNA. Translation: AEB27346.1.
RefSeqiYP_005825306.1. NC_017450.1.

Genome annotation databases

EnsemblBacteriaiAEB27346; AEB27346; FNFX1_0398.
GeneIDi12435190.
KEGGifcf:FNFX1_0398.
PATRICi54254344. VBIFraCf186347_0393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002557 Genomic DNA. Translation: AEB27346.1.
RefSeqiYP_005825306.1. NC_017450.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB27346; AEB27346; FNFX1_0398.
GeneIDi12435190.
KEGGifcf:FNFX1_0398.
PATRICi54254344. VBIFraCf186347_0393.

Phylogenomic databases

KOiK04565.
OMAiMAAGGHW.

Enzyme and pathway databases

BioCyciFNOV984129:GLDD-402-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Common ancestry and novel genetic traits of Francisella novicida-like isolates from North America and Australia as revealed by comparative genomic analyses."
    Siddaramappa S., Challacombe J.F., Petersen J.M., Pillai S., Hogg G., Kuske C.R.
    Appl. Environ. Microbiol. 77:5110-5122(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fx1Imported.

Entry informationi

Entry nameiF4BDK4_FRACF
AccessioniPrimary (citable) accession number: F4BDK4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 4, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.