F4B7K0 (F4B7K0_ACIHW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable methylcobalamin:homocysteine methyltransferase HAMAP-Rule MF_00288
EC=2.1.1.- HAMAP-Rule MF_00288

Alternative name(s):
Methionine synthase HAMAP-Rule MF_00288

Gene names

Name:	metE HAMAP-Rule MF_00288
Ordered Locus Names:	Ahos_0718

Organism

Acidianus hospitalis (strain W1) [Complete proteome] [HAMAP]

Taxonomic identifier

933801 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Acidianus › Acidianus hospitalis

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from methylcobalamin and methylcobinamide to homocysteine resulting in methionine formation By similarity. HAMAP-Rule MF_00288
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00288
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. HAMAP-Rule MF_00288
Sequence similarities	Belongs to the vitamin-B12 independent methionine synthase family. HAMAP-Rule MF_00288

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis HAMAP-Rule MF_00288
Ligand	Metal-binding HAMAP-Rule MF_00288 Zinc HAMAP-Rule MF_00288
Molecular function	Methyltransferase HAMAP-Rule MF_00288 EMBL AEE93605.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	methionine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	211	1	Zinc By similarity HAMAP-Rule MF_00288
	Metal binding	213	1	Zinc By similarity HAMAP-Rule MF_00288
	Metal binding	296	1	Zinc By similarity HAMAP-Rule MF_00288

Sequences

	Sequence		Length	Mass (Da)
	F4B7K0 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: BB23E9A2DF4D39F4	FASTA	326	37,476
	10 20 30 40 50 60 MDELPILPTT VIGSYPRPKW LREAIRLHKA GKVSDEELTE AFNDAALAVL HDHYLAGIDV 70 80 90 100 110 120 PTDGEVKRDE MVEYFAERLG GFKFYGPVRV WGTAYYRKPA VVGKIEYKSP LLVDEFNYTK 130 140 150 160 170 180 SVSYTPNVKI TITGPYTIAY WSYNEYYKDM KDLVFDLAKI INKELHNLVD AGARIIQIDE 190 200 210 220 230 240 PAIHSNKKDV SWAVEAVNEA VKGINAKLVV HICYGDYRIV APYLNEFKVD QINFALKIYN 250 260 270 280 290 300 YRYLELFKKY GYEKELGLGV IDVHSRRVES AEEVAKDIKN SLEYFPAEKI WINPDCGLKL 310 320 LPRSIAFQKL VNMVKGTKMV REELKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles." You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., She Q., Liu S.J., Garrett R.A. Extremophiles 15:487-497(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: W1.
[2]	"Genomic analyses of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles." You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., Liu S.J., Garrett R.A. Extremophiles 0:0-0(2011) Cited for: NUCLEOTIDE SEQUENCE. Strain: W1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002535 Genomic DNA. Translation: AEE93605.1.
RefSeq	YP_004457903.1. NC_015518.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AEE93605; AEE93605; Ahos_0718.
GeneID	10600172.
KEGG	aho:Ahos_0718.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00549.
Enzyme and pathway databases
BioCyc	AHOS933801:GHY6-734-MONOMER.
UniPathway	UPA00051.
Family and domain databases
HAMAP	MF_00288. MetE.
InterPro	IPR022921. MetE_arc. IPR002629. Methionine_synth. [Graphical view]
Pfam	PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F4B7K0_ACIHW

Accession

Primary (citable) accession number: F4B7K0

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)