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Protein

DNA ligase

Gene

lig

Organism
Acidianus hospitalis (strain W1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259ATPUniRule annotation1
Active sitei261N6-AMP-lysine intermediateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei281ATPUniRule annotation1
Binding sitei311ATPUniRule annotation1
Binding sitei351ATPUniRule annotation1
Binding sitei428ATPUniRule annotation1
Binding sitei434ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ahos_0613Imported
OrganismiAcidianus hospitalis (strain W1)Imported
Taxonomic identifieri933801 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeAcidianus
Proteomesi
  • UP000008458 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi933801.Ahos_0613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 474DNA_LIGASE_A3InterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
KOiK10747.
OMAiWLFEESY.
OrthoDBiPOG093Z03L0.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiView protein in InterPro
IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
PfamiView protein in Pfam
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiView protein in PROSITE
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.

Sequencei

Sequence statusi: Complete.

F4B718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKIIAEYF DRLEKISSRL QLTSLLADLF KKTDKNVIDK VVYLIQGKLW
60 70 80 90 100
PDFLGMPELG IGEKFLIRAL SIATSVSDDE IEKMYKSVGD LGQVAFDIKQ
110 120 130 140 150
KQQSASILAF LGAQKASKPL TVEKVYDDLT KVATSTGEGS RDIKIRLLAG
160 170 180 190 200
LLKDASPLEA KYLVRFVDGR LRVGIGDATI LDALAITFGG GQNFRPIVER
210 220 230 240 250
AYNLRADLGN IAKILANGGI EQLKNIKPQP GIPIRPMLAE RLSDPAEMLS
260 270 280 290 300
KVGNLALVDY KYDGERGQIH KAGDKIFIFS RRLENITNQY PDVAEYISKY
310 320 330 340 350
VKGNEFIVEG EIIPVDPETG EMRPFQELMH RKRKSDIHEA IKEYPVNVFL
360 370 380 390 400
FDLMYYEGED YTVKPLSERR KKLESIVEDN DYVHIATHII TDNVEKLKEF
410 420 430 440 450
FYQAISEGAE GVMVKSLAPD AIYQAGSRGW LWIKFKRDYQ SEMADTVDLV
460 470 480 490 500
MVGAFHGKGR KGGKYSSFLM AAYNPDKDVF ETVCKVASGF TDAELDDLQK
510 520 530 540 550
KIAELKRDSP HPRVVSTMVP DVWLTPALVA EIIGAEITIS PLHTCCKDQY
560 570 580 590 600
AEGGLSIRFP RFIRWRPDKS PEDATTNREI LEMYKSQLKK IEEKPSDQNV
Length:600
Mass (Da):67,661
Last modified:June 28, 2011 - v1
Checksum:i349B811022F48B30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002535 Genomic DNA. Translation: AEE93501.1.
RefSeqiWP_013775417.1. NC_015518.1.

Genome annotation databases

EnsemblBacteriaiAEE93501; AEE93501; Ahos_0613.
GeneIDi10600060.
KEGGiaho:Ahos_0613.

Similar proteinsi

Entry informationi

Entry nameiF4B718_ACIHW
AccessioniPrimary (citable) accession number: F4B718
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported