Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F4B718

- F4B718_ACIHW

UniProt

F4B718 - F4B718_ACIHW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA ligase

Gene

lig

Organism
Acidianus hospitalis (strain W1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei259 – 2591ATPUniRule annotation
Active sitei261 – 2611N6-AMP-lysine intermediateUniRule annotation
Binding sitei266 – 2661ATPUniRule annotation
Binding sitei281 – 2811ATPUniRule annotation
Binding sitei311 – 3111ATPUniRule annotation
Binding sitei351 – 3511ATPUniRule annotation
Binding sitei428 – 4281ATPUniRule annotation
Binding sitei434 – 4341ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAHOS933801:GHY6-621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Ahos_0613Imported
OrganismiAcidianus hospitalis (strain W1)Imported
Taxonomic identifieri933801 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeAcidianus
ProteomesiUP000008458: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4B718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFKIIAEYF DRLEKISSRL QLTSLLADLF KKTDKNVIDK VVYLIQGKLW
60 70 80 90 100
PDFLGMPELG IGEKFLIRAL SIATSVSDDE IEKMYKSVGD LGQVAFDIKQ
110 120 130 140 150
KQQSASILAF LGAQKASKPL TVEKVYDDLT KVATSTGEGS RDIKIRLLAG
160 170 180 190 200
LLKDASPLEA KYLVRFVDGR LRVGIGDATI LDALAITFGG GQNFRPIVER
210 220 230 240 250
AYNLRADLGN IAKILANGGI EQLKNIKPQP GIPIRPMLAE RLSDPAEMLS
260 270 280 290 300
KVGNLALVDY KYDGERGQIH KAGDKIFIFS RRLENITNQY PDVAEYISKY
310 320 330 340 350
VKGNEFIVEG EIIPVDPETG EMRPFQELMH RKRKSDIHEA IKEYPVNVFL
360 370 380 390 400
FDLMYYEGED YTVKPLSERR KKLESIVEDN DYVHIATHII TDNVEKLKEF
410 420 430 440 450
FYQAISEGAE GVMVKSLAPD AIYQAGSRGW LWIKFKRDYQ SEMADTVDLV
460 470 480 490 500
MVGAFHGKGR KGGKYSSFLM AAYNPDKDVF ETVCKVASGF TDAELDDLQK
510 520 530 540 550
KIAELKRDSP HPRVVSTMVP DVWLTPALVA EIIGAEITIS PLHTCCKDQY
560 570 580 590 600
AEGGLSIRFP RFIRWRPDKS PEDATTNREI LEMYKSQLKK IEEKPSDQNV
Length:600
Mass (Da):67,661
Last modified:June 28, 2011 - v1
Checksum:i349B811022F48B30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002535 Genomic DNA. Translation: AEE93501.1.
RefSeqiYP_004457799.1. NC_015518.1.

Genome annotation databases

EnsemblBacteriaiAEE93501; AEE93501; Ahos_0613.
GeneIDi10600060.
KEGGiaho:Ahos_0613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002535 Genomic DNA. Translation: AEE93501.1 .
RefSeqi YP_004457799.1. NC_015518.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEE93501 ; AEE93501 ; Ahos_0613 .
GeneIDi 10600060.
KEGGi aho:Ahos_0613.

Phylogenomic databases

KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci AHOS933801:GHY6-621-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles."
    You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., She Q., Liu S.J., Garrett R.A.
    Extremophiles 15:487-497(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W1Imported.
  2. "Genomic analyses of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles."
    You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., Liu S.J., Garrett R.A.
    Extremophiles 0:0-0(2011)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: W1.

Entry informationi

Entry nameiF4B718_ACIHW
AccessioniPrimary (citable) accession number: F4B718
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3