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F4B718

- F4B718_ACIHW

UniProt

F4B718 - F4B718_ACIHW

Protein

DNA ligase

Gene

lig

Organism
Acidianus hospitalis (strain W1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei259 – 2591ATPUniRule annotation
    Active sitei261 – 2611N6-AMP-lysine intermediateUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei281 – 2811ATPUniRule annotation
    Binding sitei311 – 3111ATPUniRule annotation
    Binding sitei351 – 3511ATPUniRule annotation
    Binding sitei428 – 4281ATPUniRule annotation
    Binding sitei434 – 4341ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAHOS933801:GHY6-621-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Ahos_0613Imported
    OrganismiAcidianus hospitalis (strain W1)Imported
    Taxonomic identifieri933801 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeAcidianus
    ProteomesiUP000008458: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F4B718-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFKIIAEYF DRLEKISSRL QLTSLLADLF KKTDKNVIDK VVYLIQGKLW    50
    PDFLGMPELG IGEKFLIRAL SIATSVSDDE IEKMYKSVGD LGQVAFDIKQ 100
    KQQSASILAF LGAQKASKPL TVEKVYDDLT KVATSTGEGS RDIKIRLLAG 150
    LLKDASPLEA KYLVRFVDGR LRVGIGDATI LDALAITFGG GQNFRPIVER 200
    AYNLRADLGN IAKILANGGI EQLKNIKPQP GIPIRPMLAE RLSDPAEMLS 250
    KVGNLALVDY KYDGERGQIH KAGDKIFIFS RRLENITNQY PDVAEYISKY 300
    VKGNEFIVEG EIIPVDPETG EMRPFQELMH RKRKSDIHEA IKEYPVNVFL 350
    FDLMYYEGED YTVKPLSERR KKLESIVEDN DYVHIATHII TDNVEKLKEF 400
    FYQAISEGAE GVMVKSLAPD AIYQAGSRGW LWIKFKRDYQ SEMADTVDLV 450
    MVGAFHGKGR KGGKYSSFLM AAYNPDKDVF ETVCKVASGF TDAELDDLQK 500
    KIAELKRDSP HPRVVSTMVP DVWLTPALVA EIIGAEITIS PLHTCCKDQY 550
    AEGGLSIRFP RFIRWRPDKS PEDATTNREI LEMYKSQLKK IEEKPSDQNV 600
    Length:600
    Mass (Da):67,661
    Last modified:June 28, 2011 - v1
    Checksum:i349B811022F48B30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002535 Genomic DNA. Translation: AEE93501.1.
    RefSeqiYP_004457799.1. NC_015518.1.

    Genome annotation databases

    EnsemblBacteriaiAEE93501; AEE93501; Ahos_0613.
    GeneIDi10600060.
    KEGGiaho:Ahos_0613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002535 Genomic DNA. Translation: AEE93501.1 .
    RefSeqi YP_004457799.1. NC_015518.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEE93501 ; AEE93501 ; Ahos_0613 .
    GeneIDi 10600060.
    KEGGi aho:Ahos_0613.

    Phylogenomic databases

    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci AHOS933801:GHY6-621-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles."
      You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., She Q., Liu S.J., Garrett R.A.
      Extremophiles 15:487-497(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: W1Imported.
    2. "Genomic analyses of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles."
      You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., Liu S.J., Garrett R.A.
      Extremophiles 0:0-0(2011)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: W1.

    Entry informationi

    Entry nameiF4B718_ACIHW
    AccessioniPrimary (citable) accession number: F4B718
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3