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F4B718 (F4B718_ACIHW) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Ahos_0613 EMBL AEE93501.1
OrganismAcidianus hospitalis (strain W1) [Complete proteome] [HAMAP] EMBL AEE93501.1
Taxonomic identifier933801 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeAcidianus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2611N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2591ATP By similarity HAMAP-Rule MF_00407
Binding site2661ATP By similarity HAMAP-Rule MF_00407
Binding site2811ATP By similarity HAMAP-Rule MF_00407
Binding site3111ATP By similarity HAMAP-Rule MF_00407
Binding site3511ATP By similarity HAMAP-Rule MF_00407
Binding site4281ATP By similarity HAMAP-Rule MF_00407
Binding site4341ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
F4B718 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 349B811022F48B30

FASTA60067,661
        10         20         30         40         50         60 
MEFKIIAEYF DRLEKISSRL QLTSLLADLF KKTDKNVIDK VVYLIQGKLW PDFLGMPELG 

        70         80         90        100        110        120 
IGEKFLIRAL SIATSVSDDE IEKMYKSVGD LGQVAFDIKQ KQQSASILAF LGAQKASKPL 

       130        140        150        160        170        180 
TVEKVYDDLT KVATSTGEGS RDIKIRLLAG LLKDASPLEA KYLVRFVDGR LRVGIGDATI 

       190        200        210        220        230        240 
LDALAITFGG GQNFRPIVER AYNLRADLGN IAKILANGGI EQLKNIKPQP GIPIRPMLAE 

       250        260        270        280        290        300 
RLSDPAEMLS KVGNLALVDY KYDGERGQIH KAGDKIFIFS RRLENITNQY PDVAEYISKY 

       310        320        330        340        350        360 
VKGNEFIVEG EIIPVDPETG EMRPFQELMH RKRKSDIHEA IKEYPVNVFL FDLMYYEGED 

       370        380        390        400        410        420 
YTVKPLSERR KKLESIVEDN DYVHIATHII TDNVEKLKEF FYQAISEGAE GVMVKSLAPD 

       430        440        450        460        470        480 
AIYQAGSRGW LWIKFKRDYQ SEMADTVDLV MVGAFHGKGR KGGKYSSFLM AAYNPDKDVF 

       490        500        510        520        530        540 
ETVCKVASGF TDAELDDLQK KIAELKRDSP HPRVVSTMVP DVWLTPALVA EIIGAEITIS 

       550        560        570        580        590        600 
PLHTCCKDQY AEGGLSIRFP RFIRWRPDKS PEDATTNREI LEMYKSQLKK IEEKPSDQNV 

« Hide

References

« Hide 'large scale' references
[1]"Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles."
You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., She Q., Liu S.J., Garrett R.A.
Extremophiles 15:487-497(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: W1 EMBL AEE93501.1.
[2]"Genomic analyses of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles."
You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D., Liu S.J., Garrett R.A.
Extremophiles 0:0-0(2011)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: W1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002535 Genomic DNA. Translation: AEE93501.1.
RefSeqYP_004457799.1. NC_015518.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEE93501; AEE93501; Ahos_0613.
GeneID10600060.
KEGGaho:Ahos_0613.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMAYIARFVV.

Enzyme and pathway databases

BioCycAHOS933801:GHY6-621-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4B718_ACIHW
AccessionPrimary (citable) accession number: F4B718
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)