Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Lactobacillus johnsonii DPC 6026
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno), Enolase (eno), Enolase (eno)
  5. Pyruvate kinase (LJP_1084c)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei68SubstrateUniRule annotation1
Active sitei95Proton donor/acceptorUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Sitei185Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
ORF Names:LJP_0351Imported
OrganismiLactobacillus johnsonii DPC 6026Imported
Taxonomic identifieri909954 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006836 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF4AEP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 22Substrate bindingUniRule annotation8
Regioni28 – 29Substrate bindingUniRule annotation2
Regioni95 – 98Substrate bindingUniRule annotation4
Regioni122 – 123Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01834
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 1 hit
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

F4AEP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVRRKLAK LVLVRHGESI ANRDNVYTGW NDVPLSKKGI EQAKNAGLKV
60 70 80 90 100
EKIAGFVPTH IHTSVLSRAI ITANIIADVC SFLYLPITKT WRLNERHYGA
110 120 130 140 150
LRGINKDVSK KIFGTKQVLE WRRGFDSVPP LLTQPVQDRR YQKYDMRLMP
160 170 180 190 200
QGESLHQTQE RLMPYFWDHI APELIAGHDQ LVVAHGSSLR ALIKKIEDIS
210 220 230
NEDIVKVEVP NAEPIVYTFD TDLHIVKKEV LH
Length:232
Mass (Da):26,644
Last modified:June 28, 2011 - v1
Checksum:i10048805D1E7E53F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002464 Genomic DNA Translation: AEB92687.1

Genome annotation databases

EnsemblBacteriaiAEB92687; AEB92687; LJP_0351
KEGGiljh:LJP_0351
PATRICifig|909954.3.peg.375

Entry informationi

Entry nameiF4AEP0_LACJH
AccessioniPrimary (citable) accession number: F4AEP0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health