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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Lactobacillus johnsonii DPC 6026
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei575 – 5751UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciLJOH909954:GLFA-921-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
ORF Names:LJP_0907cImported
OrganismiLactobacillus johnsonii DPC 6026Imported
Taxonomic identifieri909954 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006836 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F4AE04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIKKLENSS DHAMVAEEVK ILTNLLNEST RQLSGDVIFN KIQDLIKISA
60 70 80 90 100
QKDYDALEKQ IASLTNQEMI VVARYFATLP LLVNISEDVE LASEVNLLNN
110 120 130 140 150
TDQDYLGKLE DTIDLVSQKE NASEILKHVN VVPVLTAHPT QVQRKTVLEL
160 170 180 190 200
TDQIHGLLRS YREVKNGTIN QAEWTEKLRA YIEILMQTDI IRSHKLQVSN
210 220 230 240 250
EITNVLAYYP KALIPAITKF TARYQELAKK HNLNLSGATP ITMGMWIGGD
260 270 280 290 300
RDGNPYVTAE TLKLSATLQS QVIFEYYIKQ LNKLYRTISM STSYMKPSSA
310 320 330 340 350
VEKLSELSND DSPFRTNEPY RRAFYYIESR LLHTEYTLLG TADKNSFVKK
360 370 380 390 400
RDLENLDKIP VYKNPQDFKA DLITIKESLE EDHDQAVVRS FFTELLEAID
410 420 430 440 450
IFGFHLATID MRQDSSVNEA CVAELLKSAG ICDDYSDLPE KDKVKVLLNE
460 470 480 490 500
LNNDPRNLHA NNKPKSELLQ KELNIYKTAR QLKDCIGEDV IKQHIISHTE
510 520 530 540 550
SVSDLLEQAI MLKEYDLLNN QGARIQVVPL FETVEDLENS REIMKEFLNL
560 570 580 590 600
DIVKRWLASQ NNYQEIMLGY SDSNKDGGYL ASCWNLYKAQ KDLTAMGKKL
610 620 630 640 650
GVNITFMHGR GGTVGRGGGP SYEAITAQPF GSINDRIRMT EQGEIIQNKY
660 670 680 690 700
GNQDTAYYNL EMLASATIDR IVSKQIVSED NIGGFRSSMD EIVLDSNKVY
710 720 730 740 750
RKLVFETPAF LDYFLQATPI KQISNLNIGS RPAARKKITD FSGLRAIPWV
760 770 780 790 800
FSWSQSRIMF PGWYGVGSAF KHFIDANPNN LHTLKKMYQG WPFFHSLLSN
810 820 830 840 850
VDMVLSKSNM DIAKQYADLC EDEDTKKVFD TIYQEWKLTK EVILQIEGNK
860 870 880 890 900
ELLADNPSLK MSLNYRMPYF NILNYIQIEM IKRDRVDEIA GVYESILPIT
910
INGVTSGLRN SG
Length:912
Mass (Da):103,892
Last modified:June 28, 2011 - v1
Checksum:i50B1B1B483DCC84E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002464 Genomic DNA. Translation: AEB93233.1.
RefSeqiWP_014567428.1. NC_017477.1.
YP_005862183.1. NC_017477.1.

Genome annotation databases

EnsemblBacteriaiAEB93233; AEB93233; LJP_0907c.
KEGGiljh:LJP_0907c.
PATRICi54202737. VBILacJoh171132_0948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002464 Genomic DNA. Translation: AEB93233.1.
RefSeqiWP_014567428.1. NC_017477.1.
YP_005862183.1. NC_017477.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB93233; AEB93233; LJP_0907c.
KEGGiljh:LJP_0907c.
PATRICi54202737. VBILacJoh171132_0948.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciLJOH909954:GLFA-921-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Host Specific Diversity in Lactobacillus johnsonii as Evidenced by a Major Chromosomal Inversion and Phage Resistance Mechanisms."
    Guinane C.M., Kent R.M., Norberg S., Hill C., Fitzgerald G.F., Stanton C., Ross R.P.
    PLoS ONE 6:E18740-E18740(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DPC 6026Imported.

Entry informationi

Entry nameiF4AE04_LACJH
AccessioniPrimary (citable) accession number: F4AE04
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 24, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.