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Protein

Thymidine kinase

Gene

CbC4_2284

Organism
Clostridium botulinum BKT015925
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT929506:GHKW-2349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
ORF Names:CbC4_2284Imported
OrganismiClostridium botulinum BKT015925Imported
Taxonomic identifieri929506 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000007806: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

F4A740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGKSTNLM QVAHNYEERG MKVIIIKPKR DSKGGDKVIS RLGVTRKVDM
60 70 80 90 100
LLDVNENAYE RVQQICNEEG TLNCILVDEV QFLKKEQIDQ LFEIAVKLNI
110 120 130 140 150
PTICYGLRTD FQMNGFEGSM RLLLLAHSIE ELKTICSCGK KASLNGRKIN
160 170 180
GKFVFQGEQI AIDKEDNVEY ESLCPKCYLE YRDGLKR
Length:187
Mass (Da):21,345
Last modified:June 28, 2011 - v1
Checksum:iAF80C2692CACDB5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002410 Genomic DNA. Translation: AEB76949.1.
RefSeqiYP_004396946.1. NC_015425.1.

Genome annotation databases

EnsemblBacteriaiAEB76949; AEB76949; CbC4_2284.
GeneIDi10465241.
KEGGicbn:CbC4_2284.
PATRICi54459962. VBICloBot178872_2596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002410 Genomic DNA. Translation: AEB76949.1.
RefSeqiYP_004396946.1. NC_015425.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEB76949; AEB76949; CbC4_2284.
GeneIDi10465241.
KEGGicbn:CbC4_2284.
PATRICi54459962. VBICloBot178872_2596.

Phylogenomic databases

KOiK00857.

Enzyme and pathway databases

BioCyciCBOT929506:GHKW-2349-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements."
    Skarin H., Hafstrom T., Westerberg J., Segerman B.
    BMC Genomics 12:185-185(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BKT015925Imported.

Entry informationi

Entry nameiF4A740_CLOBO
AccessioniPrimary (citable) accession number: F4A740
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: January 7, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.