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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

Mahau_0981

Organism
Mahella australiensis (strain DSM 15567 / CIP 107919 / 50-1 BON)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (Mahau_0981)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (Mahau_0981)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotationImported, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Ordered Locus Names:Mahau_0981Imported
OrganismiMahella australiensis (strain DSM 15567 / CIP 107919 / 50-1 BON)Imported
Taxonomic identifieri697281 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family IV. Incertae SedisMahella
Proteomesi
  • UP000008457 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi697281.Mahau_0981.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 180FlavoproteinInterPro annotationAdd BLAST174
Domaini187 – 369DFPInterPro annotationAdd BLAST183

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
KOiK13038.
OMAiVRFIGNH.
OrthoDBiPOG091H021V.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

F4A2D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGLNNKTVV LGVTGGIAAY KAVDIVSRLK KAGVDVYVIM TRHAAQFVTP
60 70 80 90 100
LTFQSISEHP VAVDMFQPFM ADEIEHIALA KRANLFLIAP ATANIIGKIA
110 120 130 140 150
NGIADDMLST TVMATQAKVV LAPAMNTNMY LNPIVQHNIS ILKDKGYEVI
160 170 180 190 200
EPESGRLACG DYGTGRLSSP EIIVQAVMRM LNIKNDLDGK TIMVTAGPTR
210 220 230 240 250
EAIDPVRYIS NHSSGKMGYA IARAALDRGA KVLLISGPVA LTPPVGAEII
260 270 280 290 300
PVISTQDMYE AAVSRFEEVD AVIGAAAPAD YKPAEVSPVK IKKTEDAMTI
310 320 330 340 350
TLIRTPDIIK TLGRTKTRQK VVGFAAETQD VEQYARQKLV DKSMDMIVAN
360 370 380 390 400
DVSANGVGFG SDYNAVKIIR HDGNLKEVPR MPKEQVAHII LDELASLFED

SVL
Length:403
Mass (Da):43,440
Last modified:June 28, 2011 - v1
Checksum:iC2C0E065BEC06814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002360 Genomic DNA. Translation: AEE96179.1.
RefSeqiWP_013780609.1. NC_015520.1.

Genome annotation databases

EnsemblBacteriaiAEE96179; AEE96179; Mahau_0981.
KEGGimas:Mahau_0981.

Similar proteinsi

Entry informationi

Entry nameiF4A2D2_MAHA5
AccessioniPrimary (citable) accession number: F4A2D2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported