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F4A1P4 (F4A1P4_MAHA5) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity By similarity. PIRNR PIRNR001435

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity. HAMAP-Rule MF_00942

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Cofactor

Binds 1 4Fe-4S cluster By similarity. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Sequence similarities

Belongs to the Nth/MutY family. PIRNR PIRNR001435 HAMAP-Rule MF_00942

Contains 1 HhH domain. HAMAP-Rule MF_00942

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain100 – 12829HhH By similarity HAMAP-Rule MF_00942

Sites

Metal binding1881Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding1951Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding1981Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942
Metal binding2041Iron-sulfur (4Fe-4S) By similarity HAMAP-Rule MF_00942

Sequences

Sequence LengthMass (Da)Tools
F4A1P4 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 0D3885B3ECF4E51E

FASTA21323,988
        10         20         30         40         50         60 
MKTRDDIEHI LDILADCYPQ AKTALVYSNA FELLIATILS AQSTDKQVNK VTGKLFGKYK 

        70         80         90        100        110        120 
TPEDFAALEP QTLEEEIKSC GLYRTKALNI INMSKILVER YGSQVPSDPD ELQKLPGVGR 

       130        140        150        160        170        180 
KTANVVVSNA FGRPAIAVDT HVFRVTHRLG LAKSSTPLGT EKELMACIPR VLWSQAHHWF 

       190        200        210 
IYHGRNVCRA RQPKCDECRL RQYCDFYNSE AGL 

« Hide

References

[1]"The complete genome of Mahella australiensis DSM 15567."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Teshima H., Brettin T., Detter J.C., Han C., Tapia R., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Pukall R., Steenblock K., Schneider S., Klenk H.-P., Eisen J.A.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15567 / CIP 107919 / 50-1 BON.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002360 Genomic DNA. Translation: AEE97094.1.
RefSeqYP_004463916.1. NC_015520.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEE97094; AEE97094; Mahau_1918.
GeneID10608680.
KEGGmas:Mahau_1918.
PATRIC54632539. VBIMahAus157719_1958.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10773.

Enzyme and pathway databases

BioCycMAUS697281:GH33-1964-MONOMER.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPMF_00942. Nth.
InterProIPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF001435. Nth. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
TIGRFAMsTIGR01083. nth. 1 hit.
PROSITEPS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF4A1P4_MAHA5
AccessionPrimary (citable) accession number: F4A1P4
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)