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Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Desulfovibrio africanus str. Walvis Bay
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aerobic respiration Source: UniProtKB-HAMAP
  2. menaquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotation, Ubiquinone biosynthesisUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation, UbiquinoneImported

Enzyme and pathway databases

BioCyciDAFR690850:GHYW-1789-MONOMER.
UniPathwayiUPA00079; UER00169.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
Demethylmenaquinone methyltransferaseUniRule annotation
Gene namesi
Name:ubiEUniRule annotation
ORF Names:Desaf_1767Imported
OrganismiDesulfovibrio africanus str. Walvis BayImported
Taxonomic identifieri690850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000007844: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF3Z1Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

KOiK03183.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F3Z1Z5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHQPARPYG ADNSAEEHGR RVASMFGRIA GWYDFLNHAL SLGQDIYWRY
60 70 80 90 100
RLVRTLRLPE AGLVLDLAAG TMDVSLEILR QYPGARVLAM DFTEPMLRRG
110 120 130 140 150
QRKAKALARG RSAQPVLADG RRLPLPASSL DAATIAFGIR NIVPRSEAFA
160 170 180 190 200
EIHQALKPGG RLCVLEFGSG KSRVWKGLYN LYLDMILPAV GRVISGDRSA
210 220 230 240 250
YAYLAETIRG FPPAKELAAE MRAAGFAEVY WQPLLSGIVV LHVARKACEP

T
Length:251
Mass (Da):27,675
Last modified:June 28, 2011 - v1
Checksum:i18DC1F13ACC096E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003221 Genomic DNA. Translation: EGJ50103.1.
RefSeqiWP_014259863.1. NC_016629.1.
YP_005051762.1. NC_016629.1.

Genome annotation databases

EnsemblBacteriaiEGJ50103; EGJ50103; Desaf_1767.
GeneIDi11569335.
KEGGidaf:Desaf_1767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003221 Genomic DNA. Translation: EGJ50103.1.
RefSeqiWP_014259863.1. NC_016629.1.
YP_005051762.1. NC_016629.1.

3D structure databases

ProteinModelPortaliF3Z1Z5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEGJ50103; EGJ50103; Desaf_1767.
GeneIDi11569335.
KEGGidaf:Desaf_1767.

Phylogenomic databases

KOiK03183.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.
BioCyciDAFR690850:GHYW-1789-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Walvis BayImported.

Entry informationi

Entry nameiF3Z1Z5_DESAF
AccessioniPrimary (citable) accession number: F3Z1Z5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 4, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.