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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Rubrivivax benzoatilyticus JA2 = ATCC BAA-35
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase I (RBXJA2T_02592)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
ORF Names:RBXJA2T_00595Imported
OrganismiRubrivivax benzoatilyticus JA2 = ATCC BAA-35Imported
Taxonomic identifieri987059 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesRubrivivax
Proteomesi
  • UP000005494 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi987059.RBXJA2T_00595

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
KOiK09007
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

F3LKC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLTDALHI PDTQSARDER HVAIQRVGVK DVRYPLQLRV AGAVQATAAS
60 70 80 90 100
WTLDVALPAE QKGTHMSRFV AWLDALDEPL DAAALARRHA AMLDKLGARE
110 120 130 140 150
GRVEASFSFF LRKRAPVSGL QSLLDYQGRW IAETRLDGDT PKTTLWAEVA
160 170 180 190 200
VPVKSLCPCS KEISDYGAHN QRSIVTIRVE LLQPVEWHEL VRFAEDEASS
210 220 230 240 250
EIWPMLKRTD EKWVTERAYE NPKFVEDLVR DVALRLNREP RIGRYVVDVE
260
NFESIHNHSA WARIER
Length:266
Mass (Da):30,287
Last modified:June 28, 2011 - v1
Checksum:i66D9FEF43586CB72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEWG01000005 Genomic DNA Translation: EGJ08792.1
RefSeqiWP_009855360.1, NZ_ATUI01000013.1

Genome annotation databases

EnsemblBacteriaiEGJ08792; EGJ08792; RBXJA2T_00595
KEGGirbn:RBXJA2T_00595

Similar proteinsi

Entry informationi

Entry nameiF3LKC4_9BURK
AccessioniPrimary (citable) accession number: F3LKC4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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