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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas amygdali pv. lachrymans str. M302278
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotationSAAS annotation
Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotationSAAS annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei477Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 37FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
LigandFADUniRule annotationSAAS annotation, Flavoprotein, NADUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
ORF Names:PLA106_03597Imported
OrganismiPseudomonas amygdali pv. lachrymans str. M302278Imported
Taxonomic identifieri629267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonasPseudomonas amygdali
Proteomesi
  • UP000005479 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliF3IDF4
SMRiF3IDF4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 109GMC_OxRdtase_NInterPro annotationAdd BLAST24
Domaini263 – 277GMC_OxRdtase_NInterPro annotationAdd BLAST15

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

F3IDF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQSEYDYI IIGAGSAGNT LAARLTEDAG VTVLLLEAGG PDYRLDFRTQ
60 70 80 90 100
MPAALAFPLQ GRRYNWAYET EPEPHMDNRR MECGRGKGLG GSSLINGMCY
110 120 130 140 150
IRGNAMDYDG WAKEPGLEDW SYLDCLPYFR KAETRDIGPN DYHGGEGPVS
160 170 180 190 200
VTTPKAGNNP LFHAMVEAGV QAGFPRTDDL NGYQQEGFGP MDRTVTPKGR
210 220 230 240 250
RASTARGYLD EAKKRDTLSI VTHALTDRIL FEGKRAVGVA YLVGDSDTRI
260 270 280 290 300
EVRARKEVLL CGGAIASPQI LQRSGVGPAE VLNKLDIPVV HDLPGVGQNL
310 320 330 340 350
QDHLEMYLQY ACTQPVSLYP SLKWWNQPAI GAEWMFLGTG IGASNQFEAG
360 370 380 390 400
GFIRSSEAFE WPNIQYHFLP VAINYNGTKG VQEHGFQAHV GSMRSPSRGR
410 420 430 440 450
VHVKSKDPRE YPSILFNYMA SDQDWQEFRD GIRLTREIMQ QPALDPYRGR
460 470 480 490 500
EISPGIDVQS DEALDQFVRE HAETAYHPSC SCKMGTDEMA VVDGQGRVHG
510 520 530 540 550
MQNLRVVDAS IMPIITTGNL NAPTIMIAEK IADKIRGRQP LPRSTADYFV
560
AGDKPARGKP LREISHQA
Length:568
Mass (Da):62,788
Last modified:June 28, 2011 - v1
Checksum:i147045C3DDCC9005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEAM01000075 Genomic DNA Translation: EGH95043.1
RefSeqiWP_005763658.1, NZ_GL385194.1

Genome annotation databases

EnsemblBacteriaiEGH95043; EGH95043; PLA106_03597
PATRICifig|629267.3.peg.715

Similar proteinsi

Entry informationi

Entry nameiF3IDF4_PSEAV
AccessioniPrimary (citable) accession number: F3IDF4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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