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F2Z4A9

- F2Z4A9_MOUSE

UniProt

F2Z4A9 - F2Z4A9_MOUSE

Protein
Submitted name:

Probable global transcription activator SNF2L2

Gene

Smarca2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. helicase activity Source: InterPro
    3. protein binding Source: MGI
    4. RNA polymerase II transcription coactivator activity Source: Ensembl
    5. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. aortic smooth muscle cell differentiation Source: MGI
    2. chromatin organization Source: MGI
    3. negative regulation of cell growth Source: Ensembl
    4. negative regulation of cell proliferation Source: MGI
    5. negative regulation of transcription, DNA-templated Source: Ensembl
    6. nucleosome assembly Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Probable global transcription activator SNF2L2Imported
    Gene namesi
    Name:Smarca2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:99603. Smarca2.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament cytoskeleton Source: Ensembl
    2. nBAF complex Source: MGI
    3. npBAF complex Source: MGI
    4. nuclear chromatin Source: Ensembl
    5. nucleus Source: MGI
    6. SWI/SNF complex Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiF2Z4A9.

    Expressioni

    Gene expression databases

    ArrayExpressiF2Z4A9.
    BgeeiF2Z4A9.

    Structurei

    3D structure databases

    ProteinModelPortaliF2Z4A9.
    SMRiF2Z4A9. Positions 1389-1497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    BromodomainSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074659.
    KOiK11647.
    OrthoDBiEOG771265.
    TreeFamiTF300785.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR006576. BRK_domain.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR014978. Gln-Leu-Gln_QLQ.
    IPR013999. HAS_subgr.
    IPR014012. Helicase/SANT-assoc_DNA-bd.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR029295. SnAC.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF07533. BRK. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07529. HSA. 1 hit.
    PF14619. SnAC. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00592. BRK. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00573. HSA. 1 hit.
    SM00951. QLQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51204. HSA. 1 hit.
    PS51666. QLQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2Z4A9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPTDPAAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP     50
    PSVSHPLSTM GSADFPQEGM HQLHKPMDGI HDKGIVEDVH CGSMKGTSMR 100
    PPHPGMGPPQ SPMDQHSQGY MSPHPSPLGA PEHVSSPISG GGPTPPQMPP 150
    SQPGALIPGD PQAMNQPNRG PSPFSPVQLH QLRAQILAYK MLARGQPLPE 200
    TLQLAVQGKR TLPGMQQQQQ QQQQQQQQQQ QQQQQQQQQQ QPQQPQQQAQ 250
    AQPQQQQQQQ QQPALVSYNR PSGPGQELLL SGQSAPQKLS APAPSGRPSP 300
    APQAAVQPTA TAVPGPSVQQ PAPGQPSPVL QLQQKQSRIS PIQKPQGLDP 350
    VEILQEREYR LQARIAHRIQ ELESLPGSLP PDLRTKATVE LKALRLLNFQ 400
    RQLRQEVVAC MRRDTTLETA LNSKAYKRSK RQTLREARMT EKLEKQQKIE 450
    QERKRRQKHQ EYLNSILQHA KDFKEYHRSV AGKIQKLSKA VATWHANTER 500
    EQKKETERIE KERMRRLMAE DEEGYRKLID QKKDRRLAYL LQQTDEYVAN 550
    LTNLVWEHKQ AQAAKEKKKR RRRKKKAEEN AEGGEPALGP DGEPIDESSQ 600
    MSDLPVKVTH TETGKVLFGP EAPKASQLDA WLEMNPGYEV APRSDSEESE 650
    SDYEEEDEEE ESSRQETEEK ILLDPNSEEV SEKDAKQIIE TAKQDVDDEY 700
    SMQYSARGSQ SYYTVAHAIS ERVEKQSALL INGTLKHYQL QGLEWMVSLY 750
    NNNLNGILAD EMGLGKTIQT IALITYLMEH KRLNGPYLII VPLSTLSNWT 800
    YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT YEYIIKDKHI 850
    LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP 900
    ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH 950
    KVLRPFLLRR LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT 1000
    DGSEKDKKGK GGAKTLMNTI MQLRKICNHP YMFQHIEESF AEHLGYSNGV 1050
    INGAELYRAS GKFELLDRIL PKLRATNHRV LLFCQMTSLM TIMEDYFAFR 1100
    NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG GLGLNLQAAD 1150
    TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK 1200
    YKLNVDQKVI QAGMFDQKSS SHERRAFLQA ILEHEEENEE EDEVPDDETL 1250
    NQMIARREEE FDLFMRMDMD RRREDARNPK RKPRLMEEDE LPSWIIKDDA 1300
    EVERLTCEEE EEKIFGRGSR QRRDVDYSDA LTEKQWLRAI EDGNLEEMEE 1350
    EVRLKKRKRR RNVDKDPVKE DVEKAKKRRG RPPAEKLSPN PPKLTKQMNA 1400
    IIDTVINYKD SSGRQLSEVF IQLPSRKDLP EYYELIRKPV DFKKIKERIR 1450
    NHKYRSLGDL EKDVMLLCHN AQTFNLEGSQ IYEDSIVLQS VFKSARQKIA 1500
    KEEESEEESN EEEEEDDEEE SESEAKSVKV KIKLNKKEEK GRDTGKGKKR 1550
    PNRGKAKPVV SDFDSDEEQE ENEQSEASGT DNE 1583
    Length:1,583
    Mass (Da):180,722
    Last modified:May 31, 2011 - v1
    Checksum:i11584802644C363E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC118249 Genomic DNA. No translation available.
    AC118472 Genomic DNA. No translation available.
    RefSeqiNP_035546.2. NM_011416.2.
    XP_006527348.1. XM_006527285.1.
    UniGeneiMm.491146.

    Genome annotation databases

    EnsembliENSMUST00000025862; ENSMUSP00000025862; ENSMUSG00000024921.
    GeneIDi67155.
    KEGGimmu:67155.
    UCSCiuc008hbn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC118249 Genomic DNA. No translation available.
    AC118472 Genomic DNA. No translation available.
    RefSeqi NP_035546.2. NM_011416.2.
    XP_006527348.1. XM_006527285.1.
    UniGenei Mm.491146.

    3D structure databases

    ProteinModelPortali F2Z4A9.
    SMRi F2Z4A9. Positions 1389-1497.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F2Z4A9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025862 ; ENSMUSP00000025862 ; ENSMUSG00000024921 .
    GeneIDi 67155.
    KEGGi mmu:67155.
    UCSCi uc008hbn.1. mouse.

    Organism-specific databases

    CTDi 6595.
    MGIi MGI:99603. Smarca2.

    Phylogenomic databases

    GeneTreei ENSGT00550000074659.
    KOi K11647.
    OrthoDBi EOG771265.
    TreeFami TF300785.

    Miscellaneous databases

    ChiTaRSi SMARCA2. mouse.
    NextBioi 323746.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi F2Z4A9.
    Bgeei F2Z4A9.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR006576. BRK_domain.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR014978. Gln-Leu-Gln_QLQ.
    IPR013999. HAS_subgr.
    IPR014012. Helicase/SANT-assoc_DNA-bd.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR029295. SnAC.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF07533. BRK. 1 hit.
    PF00439. Bromodomain. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07529. HSA. 1 hit.
    PF14619. SnAC. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00592. BRK. 1 hit.
    SM00297. BROMO. 1 hit.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00573. HSA. 1 hit.
    SM00951. QLQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51204. HSA. 1 hit.
    PS51666. QLQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF2Z4A9_MOUSE
    AccessioniPrimary (citable) accession number: F2Z4A9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3