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Protein
Submitted name:

Probable global transcription activator SNF2L2

Gene

Smarca2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • aortic smooth muscle cell differentiation Source: MGI
  • chromatin organization Source: MGI
  • chromatin remodeling Source: InterPro
  • negative regulation of cell growth Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • nucleosome assembly Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • spermatid development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Submitted name:
Probable global transcription activator SNF2L2Imported
Gene namesi
Name:Smarca2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:99603. Smarca2.

Subcellular locationi

GO - Cellular componenti

  • BAF-type complex Source: MGI
  • intermediate filament cytoskeleton Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nBAF complex Source: MGI
  • npBAF complex Source: MGI
  • nuclear chromatin Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • SWI/SNF complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiF2Z4A9.
PRIDEiF2Z4A9.

Expressioni

Gene expression databases

BgeeiF2Z4A9.
ExpressionAtlasiF2Z4A9. baseline and differential.
GenevisibleiF2Z4A9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025862.

Structurei

3D structure databases

ProteinModelPortaliF2Z4A9.
SMRiF2Z4A9. Positions 1392-1501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 20836QLQInterPro annotationAdd
BLAST
Domaini447 – 51973HSAInterPro annotationAdd
BLAST
Domaini747 – 912166Helicase ATP-bindingInterPro annotationAdd
BLAST
Domaini1065 – 1227163Helicase C-terminalInterPro annotationAdd
BLAST
Domaini1412 – 148271BromoInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili215 – 24127Sequence analysisAdd
BLAST
Coiled coili495 – 51521Sequence analysisAdd
BLAST
Coiled coili558 – 58124Sequence analysisAdd
BLAST
Coiled coili646 – 67025Sequence analysisAdd
BLAST
Coiled coili1345 – 136521Sequence analysisAdd
BLAST
Coiled coili1492 – 152231Sequence analysisAdd
BLAST

Keywords - Domaini

BromodomainSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiCOG0553. LUCA.
COG5076. LUCA.
KOG0386. Eukaryota.
GeneTreeiENSGT00550000074659.
KOiK11647.
OrthoDBiEOG771265.
TreeFamiTF300785.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR030088. SMARCA2.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF541. PTHR10799:SF541. 4 hits.
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z4A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPTDPAAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP
60 70 80 90 100
PSVSHPLSTM GSADFPQEGM HQLHKPMDGI HDKGIVEDVH CGSMKGTSMR
110 120 130 140 150
PPHPGMGPPQ SPMDQHSQGY MSPHPSPLGA PEHVSSPISG GGPTPPQMPP
160 170 180 190 200
SQPGALIPGD PQAMNQPNRG PSPFSPVQLH QLRAQILAYK MLARGQPLPE
210 220 230 240 250
TLQLAVQGKR TLPGMQQQQQ QQQQQQQQQQ QQQQQQQQQQ QPQQPQQQAQ
260 270 280 290 300
AQPQQQQQQQ QQPALVSYNR PSGPGQELLL SGQSAPQKLS APAPSGRPSP
310 320 330 340 350
APQAAVQPTA TAVPGPSVQQ PAPGQPSPVL QLQQKQSRIS PIQKPQGLDP
360 370 380 390 400
VEILQEREYR LQARIAHRIQ ELESLPGSLP PDLRTKATVE LKALRLLNFQ
410 420 430 440 450
RQLRQEVVAC MRRDTTLETA LNSKAYKRSK RQTLREARMT EKLEKQQKIE
460 470 480 490 500
QERKRRQKHQ EYLNSILQHA KDFKEYHRSV AGKIQKLSKA VATWHANTER
510 520 530 540 550
EQKKETERIE KERMRRLMAE DEEGYRKLID QKKDRRLAYL LQQTDEYVAN
560 570 580 590 600
LTNLVWEHKQ AQAAKEKKKR RRRKKKAEEN AEGGEPALGP DGEPIDESSQ
610 620 630 640 650
MSDLPVKVTH TETGKVLFGP EAPKASQLDA WLEMNPGYEV APRSDSEESE
660 670 680 690 700
SDYEEEDEEE ESSRQETEEK ILLDPNSEEV SEKDAKQIIE TAKQDVDDEY
710 720 730 740 750
SMQYSARGSQ SYYTVAHAIS ERVEKQSALL INGTLKHYQL QGLEWMVSLY
760 770 780 790 800
NNNLNGILAD EMGLGKTIQT IALITYLMEH KRLNGPYLII VPLSTLSNWT
810 820 830 840 850
YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT YEYIIKDKHI
860 870 880 890 900
LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP
910 920 930 940 950
ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH
960 970 980 990 1000
KVLRPFLLRR LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT
1010 1020 1030 1040 1050
DGSEKDKKGK GGAKTLMNTI MQLRKICNHP YMFQHIEESF AEHLGYSNGV
1060 1070 1080 1090 1100
INGAELYRAS GKFELLDRIL PKLRATNHRV LLFCQMTSLM TIMEDYFAFR
1110 1120 1130 1140 1150
NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG GLGLNLQAAD
1160 1170 1180 1190 1200
TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK
1210 1220 1230 1240 1250
YKLNVDQKVI QAGMFDQKSS SHERRAFLQA ILEHEEENEE EDEVPDDETL
1260 1270 1280 1290 1300
NQMIARREEE FDLFMRMDMD RRREDARNPK RKPRLMEEDE LPSWIIKDDA
1310 1320 1330 1340 1350
EVERLTCEEE EEKIFGRGSR QRRDVDYSDA LTEKQWLRAI EDGNLEEMEE
1360 1370 1380 1390 1400
EVRLKKRKRR RNVDKDPVKE DVEKAKKRRG RPPAEKLSPN PPKLTKQMNA
1410 1420 1430 1440 1450
IIDTVINYKD SSGRQLSEVF IQLPSRKDLP EYYELIRKPV DFKKIKERIR
1460 1470 1480 1490 1500
NHKYRSLGDL EKDVMLLCHN AQTFNLEGSQ IYEDSIVLQS VFKSARQKIA
1510 1520 1530 1540 1550
KEEESEEESN EEEEEDDEEE SESEAKSVKV KIKLNKKEEK GRDTGKGKKR
1560 1570 1580
PNRGKAKPVV SDFDSDEEQE ENEQSEASGT DNE
Length:1,583
Mass (Da):180,722
Last modified:May 31, 2011 - v1
Checksum:i11584802644C363E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118249 Genomic DNA. No translation available.
AC118472 Genomic DNA. No translation available.
RefSeqiNP_035546.2. NM_011416.2.
XP_006527348.1. XM_006527285.1.
UniGeneiMm.491146.

Genome annotation databases

EnsembliENSMUST00000025862; ENSMUSP00000025862; ENSMUSG00000024921.
GeneIDi67155.
KEGGimmu:67155.
UCSCiuc008hbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118249 Genomic DNA. No translation available.
AC118472 Genomic DNA. No translation available.
RefSeqiNP_035546.2. NM_011416.2.
XP_006527348.1. XM_006527285.1.
UniGeneiMm.491146.

3D structure databases

ProteinModelPortaliF2Z4A9.
SMRiF2Z4A9. Positions 1392-1501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025862.

Proteomic databases

PaxDbiF2Z4A9.
PRIDEiF2Z4A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025862; ENSMUSP00000025862; ENSMUSG00000024921.
GeneIDi67155.
KEGGimmu:67155.
UCSCiuc008hbn.1. mouse.

Organism-specific databases

CTDi6595.
MGIiMGI:99603. Smarca2.

Phylogenomic databases

eggNOGiCOG0553. LUCA.
COG5076. LUCA.
KOG0386. Eukaryota.
GeneTreeiENSGT00550000074659.
KOiK11647.
OrthoDBiEOG771265.
TreeFamiTF300785.

Enzyme and pathway databases

ReactomeiR-MMU-3214858. RMTs methylate histone arginines.

Miscellaneous databases

ChiTaRSiSmarca2. mouse.
NextBioi323746.
SOURCEiSearch...

Gene expression databases

BgeeiF2Z4A9.
ExpressionAtlasiF2Z4A9. baseline and differential.
GenevisibleiF2Z4A9. MM.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR030088. SMARCA2.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF541. PTHR10799:SF541. 4 hits.
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF2Z4A9_MOUSE
AccessioniPrimary (citable) accession number: F2Z4A9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: December 9, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.