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F2Z4A9

- F2Z4A9_MOUSE

UniProt

F2Z4A9 - F2Z4A9_MOUSE

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Protein
Submitted name:

Probable global transcription activator SNF2L2

Gene
Smarca2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. helicase activity Source: InterPro
  3. protein binding Source: MGI
  4. RNA polymerase II transcription coactivator activity Source: Ensembl
  5. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. aortic smooth muscle cell differentiation Source: MGI
  2. chromatin organization Source: MGI
  3. negative regulation of cell growth Source: Ensembl
  4. negative regulation of cell proliferation Source: MGI
  5. negative regulation of transcription, DNA-templated Source: Ensembl
  6. nucleosome assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Probable global transcription activator SNF2L2Imported
Gene namesi
Name:Smarca2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:99603. Smarca2.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: Ensembl
  2. nuclear chromatin Source: Ensembl
  3. nucleus Source: MGI
  4. SWI/SNF complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF2Z4A9.

Expressioni

Gene expression databases

ArrayExpressiF2Z4A9.
BgeeiF2Z4A9.

Structurei

3D structure databases

ProteinModelPortaliF2Z4A9.
SMRiF2Z4A9. Positions 1389-1497.

Family & Domainsi

Keywords - Domaini

BromodomainSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00550000074659.
KOiK11647.
OrthoDBiEOG771265.
TreeFamiTF300785.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z4A9-1 [UniParc]FASTAAdd to Basket

« Hide

MSTPTDPAAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP     50
PSVSHPLSTM GSADFPQEGM HQLHKPMDGI HDKGIVEDVH CGSMKGTSMR 100
PPHPGMGPPQ SPMDQHSQGY MSPHPSPLGA PEHVSSPISG GGPTPPQMPP 150
SQPGALIPGD PQAMNQPNRG PSPFSPVQLH QLRAQILAYK MLARGQPLPE 200
TLQLAVQGKR TLPGMQQQQQ QQQQQQQQQQ QQQQQQQQQQ QPQQPQQQAQ 250
AQPQQQQQQQ QQPALVSYNR PSGPGQELLL SGQSAPQKLS APAPSGRPSP 300
APQAAVQPTA TAVPGPSVQQ PAPGQPSPVL QLQQKQSRIS PIQKPQGLDP 350
VEILQEREYR LQARIAHRIQ ELESLPGSLP PDLRTKATVE LKALRLLNFQ 400
RQLRQEVVAC MRRDTTLETA LNSKAYKRSK RQTLREARMT EKLEKQQKIE 450
QERKRRQKHQ EYLNSILQHA KDFKEYHRSV AGKIQKLSKA VATWHANTER 500
EQKKETERIE KERMRRLMAE DEEGYRKLID QKKDRRLAYL LQQTDEYVAN 550
LTNLVWEHKQ AQAAKEKKKR RRRKKKAEEN AEGGEPALGP DGEPIDESSQ 600
MSDLPVKVTH TETGKVLFGP EAPKASQLDA WLEMNPGYEV APRSDSEESE 650
SDYEEEDEEE ESSRQETEEK ILLDPNSEEV SEKDAKQIIE TAKQDVDDEY 700
SMQYSARGSQ SYYTVAHAIS ERVEKQSALL INGTLKHYQL QGLEWMVSLY 750
NNNLNGILAD EMGLGKTIQT IALITYLMEH KRLNGPYLII VPLSTLSNWT 800
YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT YEYIIKDKHI 850
LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP 900
ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH 950
KVLRPFLLRR LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT 1000
DGSEKDKKGK GGAKTLMNTI MQLRKICNHP YMFQHIEESF AEHLGYSNGV 1050
INGAELYRAS GKFELLDRIL PKLRATNHRV LLFCQMTSLM TIMEDYFAFR 1100
NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG GLGLNLQAAD 1150
TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK 1200
YKLNVDQKVI QAGMFDQKSS SHERRAFLQA ILEHEEENEE EDEVPDDETL 1250
NQMIARREEE FDLFMRMDMD RRREDARNPK RKPRLMEEDE LPSWIIKDDA 1300
EVERLTCEEE EEKIFGRGSR QRRDVDYSDA LTEKQWLRAI EDGNLEEMEE 1350
EVRLKKRKRR RNVDKDPVKE DVEKAKKRRG RPPAEKLSPN PPKLTKQMNA 1400
IIDTVINYKD SSGRQLSEVF IQLPSRKDLP EYYELIRKPV DFKKIKERIR 1450
NHKYRSLGDL EKDVMLLCHN AQTFNLEGSQ IYEDSIVLQS VFKSARQKIA 1500
KEEESEEESN EEEEEDDEEE SESEAKSVKV KIKLNKKEEK GRDTGKGKKR 1550
PNRGKAKPVV SDFDSDEEQE ENEQSEASGT DNE 1583
Length:1,583
Mass (Da):180,722
Last modified:May 31, 2011 - v1
Checksum:i11584802644C363E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC118249 Genomic DNA. No translation available.
AC118472 Genomic DNA. No translation available.
RefSeqiNP_035546.2. NM_011416.2.
XP_006527348.1. XM_006527285.1.
UniGeneiMm.491146.

Genome annotation databases

EnsembliENSMUST00000025862; ENSMUSP00000025862; ENSMUSG00000024921.
GeneIDi67155.
KEGGimmu:67155.
UCSCiuc008hbn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC118249 Genomic DNA. No translation available.
AC118472 Genomic DNA. No translation available.
RefSeqi NP_035546.2. NM_011416.2.
XP_006527348.1. XM_006527285.1.
UniGenei Mm.491146.

3D structure databases

ProteinModelPortali F2Z4A9.
SMRi F2Z4A9. Positions 1389-1497.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F2Z4A9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025862 ; ENSMUSP00000025862 ; ENSMUSG00000024921 .
GeneIDi 67155.
KEGGi mmu:67155.
UCSCi uc008hbn.1. mouse.

Organism-specific databases

CTDi 6595.
MGIi MGI:99603. Smarca2.

Phylogenomic databases

GeneTreei ENSGT00550000074659.
KOi K11647.
OrthoDBi EOG771265.
TreeFami TF300785.

Miscellaneous databases

ChiTaRSi SMARCA2. mouse.
NextBioi 323746.
SOURCEi Search...

Gene expression databases

ArrayExpressi F2Z4A9.
Bgeei F2Z4A9.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR013999. HAS_subgr.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF2Z4A9_MOUSE
AccessioniPrimary (citable) accession number: F2Z4A9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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