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F2Z4A5

- F2Z4A5_MOUSE

UniProt

F2Z4A5 - F2Z4A5_MOUSE

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Protein
Submitted name:

3-phosphoinositide-dependent protein kinase 1

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. phospholipase activator activity Source: Ensembl

GO - Biological processi

  1. activation of protein kinase B activity Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cell migration Source: Ensembl
  4. cellular response to epidermal growth factor stimulus Source: Ensembl
  5. cellular response to insulin stimulus Source: Ensembl
  6. epidermal growth factor receptor signaling pathway Source: Ensembl
  7. extrinsic apoptotic signaling pathway Source: Ensembl
  8. focal adhesion assembly Source: Ensembl
  9. hyperosmotic response Source: MGI
  10. negative regulation of protein kinase activity Source: Ensembl
  11. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  12. peptidyl-threonine phosphorylation Source: Ensembl
  13. positive regulation of establishment of protein localization to plasma membrane Source: Ensembl
  14. positive regulation of phospholipase activity Source: Ensembl
  15. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  16. regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  17. signal transduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
3-phosphoinositide-dependent protein kinase 1Imported
Gene namesi
Name:Pdpk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. cytosol Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF2Z4A5.

Expressioni

Gene expression databases

BgeeiF2Z4A5.
ExpressionAtlasiF2Z4A5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF2Z4A5.
SMRiF2Z4A5. Positions 49-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074819.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F2Z4A5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRSQTEPGS SPGIPSGVSR QGSTMDGTTA EARPSTNPLQ QHPAQLPPQP
60 70 80 90 100
RKKRPEDFKF GKILGEGSFS TVVLARELAT SREYAIKILE KRHIIKENKV
110 120
PYVTRERDVM SRLDHPFFVK LYFTFQDD
Length:128
Mass (Da):14,485
Last modified:May 31, 2011 - v1
Checksum:iC221A25BEBDEF0AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei128 – 1281Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000144533; ENSMUSP00000121771; ENSMUSG00000024122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F2Z4A5.
SMRi F2Z4A5. Positions 49-128.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F2Z4A5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000144533 ; ENSMUSP00000121771 ; ENSMUSG00000024122 .

Organism-specific databases

MGIi MGI:1338068. Pdpk1.

Phylogenomic databases

GeneTreei ENSGT00550000074819.

Miscellaneous databases

ChiTaRSi Pdpk1. mouse.
NextBioi 35556304.
SOURCEi Search...

Gene expression databases

Bgeei F2Z4A5.
ExpressionAtlasi F2Z4A5. baseline and differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF2Z4A5_MOUSE
AccessioniPrimary (citable) accession number: F2Z4A5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3