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F2Z4A5

- F2Z4A5_MOUSE

UniProt

F2Z4A5 - F2Z4A5_MOUSE

Protein
Submitted name:

3-phosphoinositide-dependent protein kinase 1

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of protein kinase B activity Source: Ensembl
    2. cellular response to insulin stimulus Source: Ensembl
    3. extrinsic apoptotic signaling pathway Source: Ensembl
    4. focal adhesion assembly Source: Ensembl
    5. hyperosmotic response Source: MGI
    6. intracellular signal transduction Source: Ensembl
    7. negative regulation of protein kinase activity Source: Ensembl
    8. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    9. peptidyl-threonine phosphorylation Source: Ensembl
    10. positive regulation of establishment of protein localization to plasma membrane Source: Ensembl
    11. regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    12. signal transduction Source: MGI

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-phosphoinositide-dependent protein kinase 1Imported
    Gene namesi
    Name:Pdpk1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1338068. Pdpk1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic membrane-bounded vesicle Source: MGI
    3. cytosol Source: Ensembl
    4. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF2Z4A5.

    Expressioni

    Gene expression databases

    ArrayExpressiF2Z4A5.
    BgeeiF2Z4A5.

    Structurei

    3D structure databases

    ProteinModelPortaliF2Z4A5.
    SMRiF2Z4A5. Positions 49-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00550000074819.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    F2Z4A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRSQTEPGS SPGIPSGVSR QGSTMDGTTA EARPSTNPLQ QHPAQLPPQP    50
    RKKRPEDFKF GKILGEGSFS TVVLARELAT SREYAIKILE KRHIIKENKV 100
    PYVTRERDVM SRLDHPFFVK LYFTFQDD 128
    Length:128
    Mass (Da):14,485
    Last modified:May 31, 2011 - v1
    Checksum:iC221A25BEBDEF0AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei128 – 1281Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010502 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000144533; ENSMUSP00000121771; ENSMUSG00000024122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010502 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F2Z4A5.
    SMRi F2Z4A5. Positions 49-128.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F2Z4A5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000144533 ; ENSMUSP00000121771 ; ENSMUSG00000024122 .

    Organism-specific databases

    MGIi MGI:1338068. Pdpk1.

    Phylogenomic databases

    GeneTreei ENSGT00550000074819.

    Miscellaneous databases

    ChiTaRSi PDPK1. mouse.
    NextBioi 35556304.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi F2Z4A5.
    Bgeei F2Z4A5.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF2Z4A5_MOUSE
    AccessioniPrimary (citable) accession number: F2Z4A5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3