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F2Z480

- F2Z480_MOUSE

UniProt

F2Z480 - F2Z480_MOUSE

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Protein
Submitted name:

Fibroblast growth factor receptor 2

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. fibroblast growth factor-activated receptor activity Source: InterPro
  3. fibroblast growth factor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. axonogenesis Source: MGI
  3. bone development Source: MGI
  4. bone mineralization Source: MGI
  5. bone morphogenesis Source: MGI
  6. branch elongation involved in salivary gland morphogenesis Source: MGI
  7. branching involved in labyrinthine layer morphogenesis Source: MGI
  8. branching involved in prostate gland morphogenesis Source: MGI
  9. branching involved in salivary gland morphogenesis Source: MGI
  10. branching morphogenesis of a nerve Source: MGI
  11. bud elongation involved in lung branching Source: MGI
  12. cell-cell signaling Source: MGI
  13. cell fate commitment Source: MGI
  14. coronal suture morphogenesis Source: MGI
  15. digestive tract development Source: MGI
  16. embryonic cranial skeleton morphogenesis Source: Ensembl
  17. embryonic digestive tract morphogenesis Source: MGI
  18. embryonic organ development Source: MGI
  19. embryonic organ morphogenesis Source: MGI
  20. embryonic pattern specification Source: MGI
  21. endodermal digestive tract morphogenesis Source: MGI
  22. epidermis morphogenesis Source: MGI
  23. epithelial cell differentiation Source: MGI
  24. epithelial cell proliferation Source: MGI
  25. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  26. epithelial to mesenchymal transition Source: Ensembl
  27. epithelial tube branching involved in lung morphogenesis Source: MGI
  28. fibroblast growth factor receptor signaling pathway Source: MGI
  29. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  30. gland morphogenesis Source: MGI
  31. hair follicle morphogenesis Source: MGI
  32. inner ear morphogenesis Source: MGI
  33. in utero embryonic development Source: MGI
  34. lacrimal gland development Source: MGI
  35. lateral sprouting from an epithelium Source: MGI
  36. lens fiber cell development Source: MGI
  37. limb bud formation Source: MGI
  38. lung alveolus development Source: MGI
  39. lung-associated mesenchyme development Source: MGI
  40. lung development Source: MGI
  41. lung lobe morphogenesis Source: MGI
  42. mammary gland bud formation Source: MGI
  43. membranous septum morphogenesis Source: MGI
  44. mesenchymal cell differentiation Source: MGI
  45. mesenchymal cell differentiation involved in lung development Source: MGI
  46. mesenchymal cell proliferation involved in lung development Source: MGI
  47. mesodermal cell differentiation Source: Ensembl
  48. midbrain development Source: MGI
  49. morphogenesis of embryonic epithelium Source: MGI
  50. multicellular organism growth Source: MGI
  51. negative regulation of cell proliferation Source: MGI
  52. negative regulation of epithelial cell proliferation Source: Ensembl
  53. negative regulation of mitosis Source: MGI
  54. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  55. neuromuscular junction development Source: MGI
  56. odontogenesis Source: MGI
  57. organ growth Source: MGI
  58. organ morphogenesis Source: MGI
  59. otic vesicle formation Source: MGI
  60. outflow tract septum morphogenesis Source: MGI
  61. positive regulation of canonical Wnt signaling pathway Source: MGI
  62. positive regulation of cardiac muscle cell proliferation Source: MGI
  63. positive regulation of cell division Source: MGI
  64. positive regulation of cell proliferation Source: MGI
  65. positive regulation of epithelial cell proliferation Source: MGI
  66. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
  67. positive regulation of ERK1 and ERK2 cascade Source: MGI
  68. positive regulation of mesenchymal cell proliferation Source: MGI
  69. positive regulation of phospholipase activity Source: Ensembl
  70. positive regulation of smooth muscle cell proliferation Source: Ensembl
  71. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  72. positive regulation of Wnt signaling pathway Source: MGI
  73. post-embryonic development Source: MGI
  74. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  75. prostate epithelial cord elongation Source: MGI
  76. prostate gland morphogenesis Source: MGI
  77. protein autophosphorylation Source: Ensembl
  78. regulation of branching involved in prostate gland morphogenesis Source: MGI
  79. regulation of cell fate commitment Source: MGI
  80. regulation of cell proliferation Source: MGI
  81. regulation of epithelial cell proliferation Source: MGI
  82. regulation of ERK1 and ERK2 cascade Source: MGI
  83. regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  84. regulation of morphogenesis of a branching structure Source: MGI
  85. regulation of multicellular organism growth Source: MGI
  86. regulation of smoothened signaling pathway Source: MGI
  87. regulation of smooth muscle cell differentiation Source: MGI
  88. reproductive structure development Source: MGI
  89. squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
  90. synaptic vesicle transport Source: MGI
  91. ureteric bud development Source: MGI
  92. ventricular cardiac muscle tissue morphogenesis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196534. Signaling by FGFR2 amplification mutants.
REACT_196536. Activated point mutants of FGFR2.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206745. FGFR2c ligand binding and activation.
REACT_223937. FGFR2b ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_230708. Phospholipase C-mediated cascade.
REACT_234357. FRS2-mediated cascade.
REACT_240139. PI3K Cascade.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor 2Imported
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cell surface Source: Ensembl
  3. extracellular matrix Source: Ensembl
  4. extracellular region Source: MGI
  5. integral component of plasma membrane Source: Ensembl
  6. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF2Z480.

Expressioni

Gene expression databases

BgeeiF2Z480.
ExpressionAtlasiF2Z480. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF2Z480.
SMRiF2Z480. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118923.

Family and domain databases

InterProiIPR028175. FGF_rcpt_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIADFGLAR DINNIDYYKK TTNGRLPVKW MAPEALFDRV YTHQSDVWSF
60 70 80 90 100
GVLMWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPTNCT NELYMMMRDC
110 120 130 140 150
WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY LDLTQPLEQY SPSYPDTRSS
160 170 180
CSSGDDSVFS PDPMPYEPCL PQYPHINGSV KT
Length:182
Mass (Da):21,012
Last modified:May 31, 2011 - v1
Checksum:i580F0677330916DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000124096; ENSMUSP00000130971; ENSMUSG00000030849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC099609 Genomic DNA. No translation available.
AC099627 Genomic DNA. No translation available.
AC100735 Genomic DNA. No translation available.
AC101690 Genomic DNA. No translation available.
AC101762 Genomic DNA. No translation available.
AC105062 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC119806 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC126688 Genomic DNA. No translation available.
AC138624 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC156606 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC158314 Genomic DNA. No translation available.
AC159994 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
AC238818 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F2Z480.
SMRi F2Z480. Positions 1-133.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F2Z480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000124096 ; ENSMUSP00000130971 ; ENSMUSG00000030849 .

Organism-specific databases

MGIi MGI:95523. Fgfr2.

Phylogenomic databases

GeneTreei ENSGT00760000118923.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196534. Signaling by FGFR2 amplification mutants.
REACT_196536. Activated point mutants of FGFR2.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206745. FGFR2c ligand binding and activation.
REACT_223937. FGFR2b ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_230708. Phospholipase C-mediated cascade.
REACT_234357. FRS2-mediated cascade.
REACT_240139. PI3K Cascade.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

ChiTaRSi Fgfr2. mouse.
NextBioi 35556288.
SOURCEi Search...

Gene expression databases

Bgeei F2Z480.
ExpressionAtlasi F2Z480. baseline and differential.

Family and domain databases

InterProi IPR028175. FGF_rcpt_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF2Z480_MOUSE
AccessioniPrimary (citable) accession number: F2Z480
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3