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Protein
Submitted name:

3-phosphoinositide-dependent protein kinase 1

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
  2. ATP binding Source: InterPro
  3. kinase activity Source: MGI
  4. phospholipase activator activity Source: MGI
  5. phospholipase binding Source: MGI
  6. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. activation of protein kinase B activity Source: MGI
  2. calcium-mediated signaling Source: MGI
  3. cell migration Source: MGI
  4. cellular response to epidermal growth factor stimulus Source: MGI
  5. cellular response to insulin stimulus Source: MGI
  6. epidermal growth factor receptor signaling pathway Source: MGI
  7. extrinsic apoptotic signaling pathway Source: MGI
  8. hyperosmotic response Source: MGI
  9. negative regulation of protein kinase activity Source: MGI
  10. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  11. peptidyl-threonine phosphorylation Source: MGI
  12. positive regulation of establishment of protein localization to plasma membrane Source: MGI
  13. positive regulation of phospholipase activity Source: MGI
  14. positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  15. protein phosphorylation Source: MGI
  16. regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  17. signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3-phosphoinositide-dependent protein kinase 1Imported
Gene namesi
Name:Pdpk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. neuronal postsynaptic density Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF2Z3Z9.
ExpressionAtlasiF2Z3Z9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF2Z3Z9.
SMRiF2Z3Z9. Positions 14-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074819.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR SQTEPGSSPG IPSGVSRQGS
60 70 80 90 100
TMDGTTAEAR PSTNPLQQHP AQLPPQPRKK RPEDFKFGKI LGEGSFSTVV
110 120 130 140 150
LARELATSRE YATRANSFVG TAQYVSPELL TEKSACKSSD LWALGCIIYQ
160 170 180 190 200
LVAGLPPFRA GNEYLIFQKI IKLEYHFPEK FFPKARDLVE KLLVLDATKR
210 220 230 240 250
LGCEEMEGYG PLKAHPFFET ITWENLHQQT PPKLTAYLPA MSEDDEDCYG
260 270 280 290 300
NYDNLLSQFG FMQVSSSSSS HSLSTVETSL PQRSGSNIEQ YIHDLDTNSF
310 320 330 340 350
ELDLQFSEDE KRLLLEKQAG GNPWHQFVEN NLILKMGPVD KRKGLFARRR
360 370 380 390 400
QLLLTEGPHL YYVDPVNKVL KGEIPWSQEL RPEAKNFKTF FVHTPNRTYY
410 420 430
LMDPSGNAHK WCRKIQEVWR QQYQSNPDAA VQ
Length:432
Mass (Da):48,807
Last modified:May 31, 2011 - v1
Checksum:i813502969FC52E88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000115409; ENSMUSP00000111068; ENSMUSG00000024122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF2Z3Z9.
SMRiF2Z3Z9. Positions 14-425.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115409; ENSMUSP00000111068; ENSMUSG00000024122.

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Phylogenomic databases

GeneTreeiENSGT00550000074819.

Miscellaneous databases

ChiTaRSiPdpk1. mouse.
NextBioi35556224.
SOURCEiSearch...

Gene expression databases

BgeeiF2Z3Z9.
ExpressionAtlasiF2Z3Z9. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF2Z3Z9_MOUSE
AccessioniPrimary (citable) accession number: F2Z3Z9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 4, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.