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Protein
Submitted name:

3-phosphoinositide-dependent protein kinase 1

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
  2. kinase activity Source: MGI
  3. phospholipase activator activity Source: MGI
  4. phospholipase binding Source: MGI
  5. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. activation of protein kinase B activity Source: MGI
  2. calcium-mediated signaling Source: MGI
  3. cell migration Source: MGI
  4. cellular response to epidermal growth factor stimulus Source: MGI
  5. cellular response to insulin stimulus Source: MGI
  6. epidermal growth factor receptor signaling pathway Source: MGI
  7. extrinsic apoptotic signaling pathway Source: MGI
  8. focal adhesion assembly Source: Ensembl
  9. hyperosmotic response Source: MGI
  10. negative regulation of protein kinase activity Source: MGI
  11. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  12. peptidyl-threonine phosphorylation Source: MGI
  13. positive regulation of establishment of protein localization to plasma membrane Source: MGI
  14. positive regulation of phospholipase activity Source: MGI
  15. positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  16. protein phosphorylation Source: MGI
  17. regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  18. signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3-phosphoinositide-dependent protein kinase 1Imported
Gene namesi
Name:Pdpk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. cytosol Source: Ensembl
  5. neuronal postsynaptic density Source: MGI
  6. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF2Z3X9.
ExpressionAtlasiF2Z3X9. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074819.

Sequencei

Sequence statusi: Fragment.

F2Z3X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRSQTEPGS SPGIPSGVSR QGSTMDGTTA EARPSTNPLQ QHPAQLPPQP

RKKRPE
Length:56
Mass (Da):5,963
Last modified:May 31, 2011 - v1
Checksum:i902166D678112F87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei56 – 561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000128997; ENSMUSP00000120548; ENSMUSG00000024122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128997; ENSMUSP00000120548; ENSMUSG00000024122.

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Phylogenomic databases

GeneTreeiENSGT00550000074819.

Miscellaneous databases

ChiTaRSiPdpk1. mouse.
NextBioi35556208.
SOURCEiSearch...

Gene expression databases

BgeeiF2Z3X9.
ExpressionAtlasiF2Z3X9. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF2Z3X9_MOUSE
AccessioniPrimary (citable) accession number: F2Z3X9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 4, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.