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Protein
Submitted name:

3-phosphoinositide-dependent protein kinase 1

Gene

Pdpk1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 3-phosphoinositide-dependent protein kinase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. kinase activity Source: MGI
  4. phospholipase activator activity Source: MGI
  5. phospholipase binding Source: MGI
  6. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. activation of protein kinase B activity Source: MGI
  2. calcium-mediated signaling Source: MGI
  3. cell migration Source: MGI
  4. cellular response to epidermal growth factor stimulus Source: MGI
  5. cellular response to insulin stimulus Source: MGI
  6. epidermal growth factor receptor signaling pathway Source: MGI
  7. extrinsic apoptotic signaling pathway Source: MGI
  8. focal adhesion assembly Source: Ensembl
  9. hyperosmotic response Source: MGI
  10. negative regulation of protein kinase activity Source: MGI
  11. negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  12. peptidyl-threonine phosphorylation Source: MGI
  13. positive regulation of establishment of protein localization to plasma membrane Source: MGI
  14. positive regulation of phospholipase activity Source: MGI
  15. positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  16. protein phosphorylation Source: MGI
  17. regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  18. signal transduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
3-phosphoinositide-dependent protein kinase 1Imported
Gene namesi
Name:Pdpk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1338068. Pdpk1.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. cytosol Source: Ensembl
  5. neuronal postsynaptic density Source: MGI
  6. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF2Z3X6.
ExpressionAtlasiF2Z3X6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF2Z3X6.
SMRiF2Z3X6. Positions 18-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074819.
KOiK06276.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z3X6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRSQTEPGS SPGIPSGVSR QGSTMDGTTA EARPSTNPLQ QHPAQLPPQP
60 70 80 90 100
RKKRPEDFKF GKILGEGSFS TVVLARELAT SREYAIKILE KRHIIKENKV
110 120 130 140 150
PYVTRERDVM SRLDHPFFVK LYFTFQDDEK LYFGLSYAKN GELLKYIRKI
160 170 180 190 200
GSFDETCTRF YTAEIVSALE YLHGKGIIHR DLKPENILLN EDMHIQITDF
210 220 230 240 250
GTAKVLSPES KQARANSFVG TAQYVSPELL TEKSACKSSD LWALGCIIYQ
260 270 280 290 300
LVAGLPPFRA GNEYLIFQKI IKLEYHFPEK FFPKARDLVE KLLVLDATKR
310 320 330 340 350
LGCEEMEGYG PLKAHPFFET ITWENLHQQT PPKLTAYLPA MSEDDEDCYG
360 370 380 390 400
NYDNLLSQFG FMQVSSSSSS HSLSTVETSL PQRSGSNIEQ YIHDLDTNSF
410 420 430 440 450
ELDLQFSEDE KRLLLEKQAG GNPWHQFVEN NLILKMGPVD KRKGLFARRR
460 470 480 490 500
QLLLTEGPHL YYVDPVNKVL KGEIPWSQEL RPEAKNFKTF FVHTPNRTYY
510 520 530
LMDPSGNAHK WCRKIQEVWR QQYQSNPDAA VQ
Length:532
Mass (Da):60,935
Last modified:May 31, 2011 - v1
Checksum:i10EEAF5D197B157C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.
RefSeqiNP_001273591.1. NM_001286662.1.
XP_006523886.1. XM_006523823.1.
XP_006523887.1. XM_006523824.1.
XP_006523888.1. XM_006523825.1.
XP_006523889.1. XM_006523826.1.
XP_006523892.1. XM_006523829.1.
UniGeneiMm.10504.

Genome annotation databases

EnsembliENSMUST00000052462; ENSMUSP00000061942; ENSMUSG00000024122.
GeneIDi18607.
KEGGimmu:18607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010502 Genomic DNA. No translation available.
RefSeqiNP_001273591.1. NM_001286662.1.
XP_006523886.1. XM_006523823.1.
XP_006523887.1. XM_006523824.1.
XP_006523888.1. XM_006523825.1.
XP_006523889.1. XM_006523826.1.
XP_006523892.1. XM_006523829.1.
UniGeneiMm.10504.

3D structure databases

ProteinModelPortaliF2Z3X6.
SMRiF2Z3X6. Positions 18-525.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052462; ENSMUSP00000061942; ENSMUSG00000024122.
GeneIDi18607.
KEGGimmu:18607.

Organism-specific databases

CTDi5170.
MGIiMGI:1338068. Pdpk1.

Phylogenomic databases

GeneTreeiENSGT00550000074819.
KOiK06276.

Miscellaneous databases

ChiTaRSiPdpk1. mouse.
NextBioi35556205.
SOURCEiSearch...

Gene expression databases

BgeeiF2Z3X6.
ExpressionAtlasiF2Z3X6. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF2Z3X6_MOUSE
AccessioniPrimary (citable) accession number: F2Z3X6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.