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F2Z3T0

- F2Z3T0_RAT

UniProt

F2Z3T0 - F2Z3T0_RAT

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Protein
Submitted name: Parafibromin
Gene
Cdc73
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. endodermal cell fate commitment Source: Ensembl
  3. histone H2B ubiquitination Source: Ensembl
  4. histone monoubiquitination Source: Ensembl
  5. mRNA polyadenylation Source: Ensembl
  6. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  7. negative regulation of epithelial cell proliferation Source: Ensembl
  8. negative regulation of fibroblast proliferation Source: Ensembl
  9. negative regulation of myeloid cell differentiation Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. positive regulation of Wnt signaling pathway Source: Ensembl
  12. positive regulation of mRNA 3'-end processing Source: Ensembl
  13. positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
  14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. protein destabilization Source: Ensembl
  16. stem cell maintenance Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_226234. formation of the beta-catenin:TCF transactivating complex.

Names & Taxonomyi

Protein namesi
Submitted name:
ParafibrominImported
Gene namesi
Name:Cdc73Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1311766. Cdc73.

Subcellular locationi

GO - Cellular componenti

  1. Cdc73/Paf1 complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF2Z3T0.

Structurei

3D structure databases

ProteinModelPortaliF2Z3T0.
SMRiF2Z3T0. Positions 358-523.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000001114.
OMAiEYYTLEC.
OrthoDBiEOG7KM5SP.
TreeFamiTF313016.

Family and domain databases

InterProiIPR007852. RNA_pol_access_fac_Cdc73.
[Graphical view]
PANTHERiPTHR12466. PTHR12466. 1 hit.
PfamiPF05179. CDC73. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z3T0-1 [UniParc]FASTAAdd to Basket

« Hide

MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ    50
PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG 100
EASTSASIDR SAPLEIGLQR STQVKRAADE VLAEAKKPRI EDEECVRLDK 150
ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD 200
LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFSKNIF 250
AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG 300
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP 350
PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE 400
NETLIQRRKD QMQPGGTAIS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP 450
AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS 500
YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F 531
Length:531
Mass (Da):60,577
Last modified:May 31, 2011 - v1
Checksum:i894A7448DBC0E793
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06075147 Genomic DNA. No translation available.
AABR06075148 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000004495; ENSRNOP00000004495; ENSRNOG00000003258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06075147 Genomic DNA. No translation available.
AABR06075148 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F2Z3T0.
SMRi F2Z3T0. Positions 358-523.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F2Z3T0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004495 ; ENSRNOP00000004495 ; ENSRNOG00000003258 .

Organism-specific databases

RGDi 1311766. Cdc73.

Phylogenomic databases

GeneTreei ENSGT00390000001114.
OMAi EYYTLEC.
OrthoDBi EOG7KM5SP.
TreeFami TF313016.

Enzyme and pathway databases

Reactomei REACT_226234. formation of the beta-catenin:TCF transactivating complex.

Miscellaneous databases

NextBioi 35583339.
PROi F2Z3T0.

Family and domain databases

InterProi IPR007852. RNA_pol_access_fac_Cdc73.
[Graphical view ]
PANTHERi PTHR12466. PTHR12466. 1 hit.
Pfami PF05179. CDC73. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiF2Z3T0_RAT
AccessioniPrimary (citable) accession number: F2Z3T0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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