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F2Z3T0

- F2Z3T0_RAT

UniProt

F2Z3T0 - F2Z3T0_RAT

Protein
Submitted name:

Parafibromin

Gene

Cdc73

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: Ensembl
    2. endodermal cell fate commitment Source: Ensembl
    3. histone H2B ubiquitination Source: Ensembl
    4. histone monoubiquitination Source: Ensembl
    5. mRNA polyadenylation Source: Ensembl
    6. negative regulation of epithelial cell proliferation Source: Ensembl
    7. negative regulation of fibroblast proliferation Source: Ensembl
    8. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    9. negative regulation of myeloid cell differentiation Source: Ensembl
    10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. positive regulation of mRNA 3'-end processing Source: Ensembl
    12. positive regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. positive regulation of Wnt signaling pathway Source: Ensembl
    15. protein destabilization Source: Ensembl
    16. stem cell maintenance Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ParafibrominImported
    Gene namesi
    Name:Cdc73Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1311766. Cdc73.

    Subcellular locationi

    GO - Cellular componenti

    1. Cdc73/Paf1 complex Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF2Z3T0.

    Structurei

    3D structure databases

    ProteinModelPortaliF2Z3T0.
    SMRiF2Z3T0. Positions 358-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000001114.
    OMAiEYYTLEC.
    OrthoDBiEOG7KM5SP.
    TreeFamiTF313016.

    Family and domain databases

    InterProiIPR007852. RNA_pol_access_fac_Cdc73.
    [Graphical view]
    PANTHERiPTHR12466. PTHR12466. 1 hit.
    PfamiPF05179. CDC73. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2Z3T0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ    50
    PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG 100
    EASTSASIDR SAPLEIGLQR STQVKRAADE VLAEAKKPRI EDEECVRLDK 150
    ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD 200
    LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFSKNIF 250
    AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG 300
    KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP 350
    PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE 400
    NETLIQRRKD QMQPGGTAIS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP 450
    AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS 500
    YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F 531
    Length:531
    Mass (Da):60,577
    Last modified:May 31, 2011 - v1
    Checksum:i894A7448DBC0E793
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06075147 Genomic DNA. No translation available.
    AABR06075148 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSRNOT00000004495; ENSRNOP00000004495; ENSRNOG00000003258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06075147 Genomic DNA. No translation available.
    AABR06075148 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F2Z3T0.
    SMRi F2Z3T0. Positions 358-523.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F2Z3T0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004495 ; ENSRNOP00000004495 ; ENSRNOG00000003258 .

    Organism-specific databases

    RGDi 1311766. Cdc73.

    Phylogenomic databases

    GeneTreei ENSGT00390000001114.
    OMAi EYYTLEC.
    OrthoDBi EOG7KM5SP.
    TreeFami TF313016.

    Enzyme and pathway databases

    Reactomei REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Miscellaneous databases

    NextBioi 35583339.
    PROi F2Z3T0.

    Family and domain databases

    InterProi IPR007852. RNA_pol_access_fac_Cdc73.
    [Graphical view ]
    PANTHERi PTHR12466. PTHR12466. 1 hit.
    Pfami PF05179. CDC73. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiF2Z3T0_RAT
    AccessioniPrimary (citable) accession number: F2Z3T0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3