F2Z3L0 (F2Z3L0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
SH3 and multiple ankyrin repeat domains protein 3 Ensembl ENSP00000442518

Gene names

Name:

SHANK3 Ensembl ENSP00000442518

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000442518

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1747 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000442518

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from electronic annotation. Source: Compara N-methyl-D-aspartate receptor clustering Inferred from electronic annotation. Source: Compara alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering Inferred from electronic annotation. Source: Compara brain morphogenesis Inferred from electronic annotation. Source: Compara dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara embryonic epithelial tube formation Inferred from electronic annotation. Source: Compara guanylate kinase-associated protein clustering Inferred from electronic annotation. Source: Compara learning Inferred from electronic annotation. Source: Compara locomotory exploration behavior Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara negative regulation of actin filament bundle assembly Inferred from electronic annotation. Source: Compara negative regulation of cell volume Inferred from electronic annotation. Source: Compara neuromuscular process controlling balance Inferred from electronic annotation. Source: Compara positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from electronic annotation. Source: Compara positive regulation of dendritic spine development Inferred from electronic annotation. Source: Compara positive regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara positive regulation of glutamate receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara positive regulation of synapse structural plasticity Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara postsynaptic density assembly Inferred from electronic annotation. Source: Compara protein oligomerization Inferred from electronic annotation. Source: Compara regulation of behavioral fear response Inferred from electronic annotation. Source: Compara regulation of dendritic spine morphogenesis Inferred from electronic annotation. Source: Compara regulation of grooming behavior Inferred from electronic annotation. Source: Compara regulation of long term synaptic depression Inferred from electronic annotation. Source: Compara regulation of long-term synaptic potentiation Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara striatal medium spiny neuron differentiation Inferred from electronic annotation. Source: Compara vocalization behavior Inferred from electronic annotation. Source: Compara
Cellular_component	cilium membrane Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F2Z3L0 [UniParc]. Last modified May 31, 2011. Version 1. Checksum: 10C06FE62171A858	FASTA	1,747	186,490
	10 20 30 40 50 60 MDGPGASAVV VRVGIPDLQQ TKCLRLDPAA PVWAAKQRVL CALNHSLQDA LNYGLFQPPS 70 80 90 100 110 120 RGRAGKFLDE ERLLQEYPPN LDTPLPYLEF RYKRRVYAQN LIDDKQFAKL HTKANLKKFM 130 140 150 160 170 180 DYVQLHSTDK VARLLDKGLD PNFHDPDSGE CPLSLAAQLD NATDLLKVLK NGGAHLDFRT 190 200 210 220 230 240 RDGLTAVHCA TRQRNAAALT TLLDLGASPD YKDSRGLTPL YHSALGGGDA LCCELLLHDH 250 260 270 280 290 300 AQLGITDENG WQEIHQACRF GHVQHLEHLL FYGADMGAQN ASGNTALHIC ALYNQESCAR 310 320 330 340 350 360 VLLFRGANRD VRNYNSQTAF QVAIIAGNFE LAEVIKTHKD SDVVPFRETP SYAKRRRLAG 370 380 390 400 410 420 PSGLASPRPL QRSASDINLK GEAQPAASPG PSLRSLPHQL LLQRLQEEKD RDRDADQESN 430 440 450 460 470 480 ISGPLAGRAG QSKISDPGPG PGGVGGAPLP PPGAPRSCIR IRARFPAPPA PPAPPPRGPK 490 500 510 520 530 540 RKLYSAVPGR KFIAVKAHSP QGEGEIPLHR GEAVKVLSIG EGGFWEGTVK GRTGWFPADC 550 560 570 580 590 600 VEEVQMRQHD TRPETREDRT KRLFRHYTVG SYDSLTSHSD YVIDDKVAVL QKRDHEGFGF 610 620 630 640 650 660 VLRGAKAETP IEEFTPTPAF PALQYLESVD VEGVAWRAGL RTGDFLIEVN GVNVVKVGHK 670 680 690 700 710 720 QVVALIRQGG NRLVMKVVSV TRKPEEDGAR RRAPPPPKRA PSTTLTLRSK SMTAELEELA 730 740 750 760 770 780 SIRRRKGEKL DEMLAAAAEP TLRPDIADAD SRAATVKQRP TSRRITPAEI SSLFERQGLP 790 800 810 820 830 840 GPEKLPGSLR KGIPRTKSVG EDEKLASLLE GRFPRSTSMQ DPVREGRGIP PPPQTAPPPP 850 860 870 880 890 900 PAPYYFDSGP PPAFSPPPPP GRAYDTVRSS FKPGLEARLG AGAAGLYEPG AALGPLPYPE 910 920 930 940 950 960 RQKRARSMII LQDSAPESGD APRPPPAATP PERPKRRPRP PGPDSPYANL GAFSASLFAP 970 980 990 1000 1010 1020 SKPQRRKSPL VKQLQVEDAQ ERAALAVGSP GPGGGSFARE PSPTHRGPRP GGLDYGAGDG 1030 1040 1050 1060 1070 1080 PGLAFGGPGP AKDRRLEERR RSTVFLSVGA IEGSAPGADL PSLQPSRSID ERLLGTGPTA 1090 1100 1110 1120 1130 1140 GRDLLLPSPV SALKPLVSGP SLGPSGSTFI HPLTGKPLDP SSPLALALAA RERALASQAP 1150 1160 1170 1180 1190 1200 SRSPTPVHSP DADRPGPLFV DVQARDPERG SLASPAFSPR SPAWIPVPAR REAEKVPREE 1210 1220 1230 1240 1250 1260 RKSPEDKKSM ILSVLDTSLQ RPAGLIVVHA TSNGQEPSRL GGAEEERPGT PELAPAPMQS 1270 1280 1290 1300 1310 1320 AAVAEPLPSP RAQPPGGTPA DAGPGQGSSE EEPELVFAVN LPPAQLSSSD EETREELARI 1330 1340 1350 1360 1370 1380 GLVPPPEEFA NGVLLATPLA GPGPSPTTVP SPASGKPSSE PPPAPESAAD SGVEEADTRS 1390 1400 1410 1420 1430 1440 SSDPHLETTS TISTVSSMST LSSESGELTD THTSFADGHT FLLEKPPVPP KPKLKSPLGK 1450 1460 1470 1480 1490 1500 GPVTFRDPLL KQSSDSELMA QQHHAASAGL ASAAGPARPR YLFQRRSKLW GDPVESRGLP 1510 1520 1530 1540 1550 1560 GPEDDKPTVI SELSSRLQQL NKDTRSLGEE PVGGLGSLLD PAKKSPIAAA RLFSSLGELS 1570 1580 1590 1600 1610 1620 SISAQRSPGG PGGGASYSVR PSGRYPVARR APSPVKPASL ERVEGLGAGA GGAGRPFGLT 1630 1640 1650 1660 1670 1680 PPTILKSSSL SIPHEPKEVR FVVRSVSARS RSPSPSPLPS PASGPGPGAP GPRRPFQQKP 1690 1700 1710 1720 1730 1740 LQLWSKFDVG DWLESIHLGE HRDRFEDHEI EGAHLPALTK DDFVELGVTR VGHRMNIERA LRQLDGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (NOV-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC000036 Genomic DNA. No translation available. AC000050 Genomic DNA. No translation available.
IPI	IPI00019794.
3D structure databases
ProteinModelPortal	F2Z3L0.
SMR	F2Z3L0. Positions 579-684, 1681-1744.
ModBase	Search...
Proteomic databases
PRIDE	F2Z3L0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262795; ENSP00000442518; ENSG00000251322.
UCSC	uc003bne.1. human.
Organism-specific databases
HGNC	HGNC:14294. SHANK3.
GenAtlas	Search...
Phylogenomic databases
OMA	KFIAVKA.
Gene expression databases
ArrayExpress	F2Z3L0.
Bgee	F2Z3L0.
Family and domain databases
Gene3D	1.10.150.50. 1 hit. 1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001478. PDZ. IPR001660. SAM. IPR013761. SAM/pointed. IPR021129. SAM_type1. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF00595. PDZ. 1 hit. PF00536. SAM_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. SM00228. PDZ. 1 hit. SM00454. SAM. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF50156. PDZ. 1 hit. SSF47769. SAM_homology. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50106. PDZ. 1 hit. PS50105. SAM_DOMAIN. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SHANK3. human.
NextBio	33736091.

Entry information

Entry name

F2Z3L0_HUMAN

Accession

Primary (citable) accession number: F2Z3L0

Entry history

Integrated into UniProtKB/TrEMBL:	May 31, 2011
Last sequence update:	May 31, 2011
Last modified:	April 3, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.