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Protein
Submitted name:

Interferon regulatory factor 4

Gene

IRF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiF2Z3D5.

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 4Imported
Gene namesi
Name:IRF4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6119. IRF4.

PTM / Processingi

Proteomic databases

PaxDbiF2Z3D5.
PeptideAtlasiF2Z3D5.

Expressioni

Gene expression databases

BgeeiENSG00000137265.
ExpressionAtlasiF2Z3D5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370343.

Structurei

3D structure databases

ProteinModelPortaliF2Z3D5.
SMRiF2Z3D5. Positions 18-130, 252-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 129109IRF tryptophan pentad repeat DNA-bindingInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IES5. Eukaryota.
ENOG411023V. LUCA.
GeneTreeiENSGT00760000119093.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiIPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]
PRINTSiPR00267. INTFRNREGFCT.
SMARTiSM00348. IRF. 1 hit.
SM01243. IRF-3. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiPS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2Z3D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEGGGRGG EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF
60 70 80 90 100
RIPWKHAGKQ DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA
110 120 130 140 150
LNKSNDFEEL VERSQLDISD PYKVYRIVPE GAKKGAKQLT LEDPQMSMSH
160 170 180 190 200
PYTMTTPYPS LPAQQVHNYM MPPLDRSWRD YVPDQPHPEI PYQCPMTFGP
210 220 230 240 250
RGHHWQGPAC ENGCQVTGTF YACAPPESQA PGVPTEPSIR SAEALAFSDC
260 270 280 290 300
RLHICLYYRE ILVKELTTSS PEGCRISHGH TYDASNLDQV LFPYPEDNGQ
310 320 330 340 350
RKNIEKLLSH LERGVVLWMA PDGLYAKRLC QSRIYWDGPL ALCNDRPNKL
360 370 380 390 400
ERDQTCKLFD TQQFLSELQA FAHHGRSLPR FQVTLCFGEE FPDPQRQRKL
410
ITAHVLRSLA
Length:410
Mass (Da):46,817
Last modified:May 31, 2011 - v1
Checksum:i2F0C6652571BD75F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365272 Genomic DNA. No translation available.
AL512308 Genomic DNA. No translation available.
AL589962 Genomic DNA. No translation available.
KF458069 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000493114; ENSP00000436094; ENSG00000137265.
UCSCiuc063ljg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365272 Genomic DNA. No translation available.
AL512308 Genomic DNA. No translation available.
AL589962 Genomic DNA. No translation available.
KF458069 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF2Z3D5.
SMRiF2Z3D5. Positions 18-130, 252-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370343.

Proteomic databases

PaxDbiF2Z3D5.
PeptideAtlasiF2Z3D5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493114; ENSP00000436094; ENSG00000137265.
UCSCiuc063ljg.1. human.

Organism-specific databases

HGNCiHGNC:6119. IRF4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IES5. Eukaryota.
ENOG411023V. LUCA.
GeneTreeiENSGT00760000119093.

Enzyme and pathway databases

SignaLinkiF2Z3D5.

Miscellaneous databases

ChiTaRSiIRF4. human.

Gene expression databases

BgeeiENSG00000137265.
ExpressionAtlasiF2Z3D5. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiIPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
[Graphical view]
PRINTSiPR00267. INTFRNREGFCT.
SMARTiSM00348. IRF. 1 hit.
SM01243. IRF-3. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiPS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF2Z3D5_HUMAN
AccessioniPrimary (citable) accession number: F2Z3D5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 7, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.