POU5F1

Functionⁱ

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-UniRule

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotationImported
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: POU class 5 homeobox 1 transcript variant 6Imported Submitted name: POU class 5 homeobox 1 transcript variant OCT4B1Imported Submitted name: POU class 5 homeobox 1 transcript variant OCT4B2Imported Submitted name: POU class 5 homeobox 1 transcript variant OCT4B3Imported Submitted name: POU domain, class 5, transcription factor 1Imported
Gene namesⁱ	Name:POU5F1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9221. POU5F1.

HGNCⁱ

HGNC:9221. POU5F1.

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00530
- RuleBase:RU000682
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00553137

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000204531.

OpenTargetsⁱ

ENSG00000204531.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204531.
ExpressionAtlasⁱ	F2Z381. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	F2Z381.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 16	POU-specificInterPro annotationAdd BLAST		16
Domainⁱ	32 – 92	Homeobox DNA-bindingInterPro annotationAdd BLAST		61

Keywords - Domainⁱ

HomeoboxUniRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGⁱ	KOG3802. Eukaryota. ENOG410XQ7X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR013847. POU. IPR000327. POU_dom. IPR015585. POU_dom_5.
PANTHERⁱ	PTHR11636:SF100. PTHR11636:SF100. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
PRINTSⁱ	PR00028. POUDOMAIN.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS51179. POU_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F2Z381-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCKLRPLLQK WVEEADNNEN LQEICKAETL VQARKRKRTS IENRVRGNLE 
        60         70         80         90        100
NLFLQCPKPT LQQISHIAQQ LGLEKDVVRV WFCNRRQKGK RSSSDYAQRE 
       110        120        130        140        150
DFEAAGSPFS GGPVSFPLAP GPHFGTPGYG SPHFTALYSS VPFPEGEAFP 
       160 
PVSVTTLGSP MHSN

Length:164

Mass (Da):18,311

Last modified:May 31, 2011 - v1

Checksum:ⁱF7118F4DE7DEBDD6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL662844 Genomic DNA. No translation available. KF880692 mRNA. Translation: AID57228.1. KF880693 mRNA. Translation: AID57229.1. KJ624996 mRNA. Translation: AIK29475.1. KJ700311 mRNA. Translation: AIK29476.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001272915.1. NM_001285986.1.
UniGeneⁱ	Hs.249184.

Genome annotation databases

Ensemblⁱ	ENST00000441888; ENSP00000389359; ENSG00000204531. ENST00000471529; ENSP00000425083; ENSG00000204531. ENST00000512818; ENSP00000425479; ENSG00000204531. ENST00000513407; ENSP00000475512; ENSG00000204531.
GeneIDⁱ	5460.
UCSC genome browser More...UCSCⁱ	uc032wqt.2. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL662844 Genomic DNA. No translation available. KF880692 mRNA. Translation: AID57228.1. KF880693 mRNA. Translation: AID57229.1. KJ624996 mRNA. Translation: AIK29475.1. KJ700311 mRNA. Translation: AIK29476.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001272915.1. NM_001285986.1.
UniGeneⁱ	Hs.249184.

3D structure databases

SMRⁱ	F2Z381.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000441888; ENSP00000389359; ENSG00000204531. ENST00000471529; ENSP00000425083; ENSG00000204531. ENST00000512818; ENSP00000425479; ENSG00000204531. ENST00000513407; ENSP00000475512; ENSG00000204531.
GeneIDⁱ	5460.
UCSC genome browser More...UCSCⁱ	uc032wqt.2. human.

Organism-specific databases

CTDⁱ	5460.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9221. POU5F1.
Open Targets More...OpenTargetsⁱ	ENSG00000204531.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3802. Eukaryota. ENOG410XQ7X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935.

Miscellaneous databases

GenomeRNAiⁱ	5460.

GenomeRNAiⁱ

5460.

Gene expression databases

Bgeeⁱ	ENSG00000204531.
ExpressionAtlasⁱ	F2Z381. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR013847. POU. IPR000327. POU_dom. IPR015585. POU_dom_5.
PANTHERⁱ	PTHR11636:SF100. PTHR11636:SF100. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit.
PRINTSⁱ	PR00028. POUDOMAIN.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS51179. POU_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F2Z381_HUMAN
Accessionⁱ	F2Z381Primary (citable) accession number: F2Z381
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 31, 2011
	Last sequence update:	May 31, 2011
	Last modified:	July 5, 2017
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F2Z381 (F2Z381_HUMAN)

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POU class 5 homeobox 1 transcript variant 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ