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Protein
Submitted name:

POU class 5 homeobox 1 transcript variant 6

Gene

POU5F1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
POU class 5 homeobox 1 transcript variant 6Imported
Submitted name:
POU class 5 homeobox 1 transcript variant OCT4B1Imported
Submitted name:
POU class 5 homeobox 1 transcript variant OCT4B2Imported
Submitted name:
POU class 5 homeobox 1 transcript variant OCT4B3Imported
Submitted name:
POU domain, class 5, transcription factor 1Imported
Gene namesi
Name:POU5F1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9221. POU5F1.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204531.

Expressioni

Gene expression databases

BgeeiENSG00000204531.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 16POU-specificInterPro annotationAdd BLAST16
Domaini32 – 92Homeobox DNA-bindingInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
PANTHERiPTHR11636:SF100. PTHR11636:SF100. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

F2Z381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKLRPLLQK WVEEADNNEN LQEICKAETL VQARKRKRTS IENRVRGNLE
60 70 80 90 100
NLFLQCPKPT LQQISHIAQQ LGLEKDVVRV WFCNRRQKGK RSSSDYAQRE
110 120 130 140 150
DFEAAGSPFS GGPVSFPLAP GPHFGTPGYG SPHFTALYSS VPFPEGEAFP
160
PVSVTTLGSP MHSN
Length:164
Mass (Da):18,311
Last modified:May 31, 2011 - v1
Checksum:iF7118F4DE7DEBDD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662844 Genomic DNA. No translation available.
KF880692 mRNA. Translation: AID57228.1.
KF880693 mRNA. Translation: AID57229.1.
KJ624996 mRNA. Translation: AIK29475.1.
KJ700311 mRNA. Translation: AIK29476.1.
RefSeqiNP_001272915.1. NM_001285986.1.
UniGeneiHs.249184.

Genome annotation databases

EnsembliENST00000441888; ENSP00000389359; ENSG00000204531.
ENST00000471529; ENSP00000425083; ENSG00000204531.
ENST00000512818; ENSP00000425479; ENSG00000204531.
ENST00000513407; ENSP00000475512; ENSG00000204531.
GeneIDi5460.
UCSCiuc032wqt.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662844 Genomic DNA. No translation available.
KF880692 mRNA. Translation: AID57228.1.
KF880693 mRNA. Translation: AID57229.1.
KJ624996 mRNA. Translation: AIK29475.1.
KJ700311 mRNA. Translation: AIK29476.1.
RefSeqiNP_001272915.1. NM_001285986.1.
UniGeneiHs.249184.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000259915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441888; ENSP00000389359; ENSG00000204531.
ENST00000471529; ENSP00000425083; ENSG00000204531.
ENST00000512818; ENSP00000425479; ENSG00000204531.
ENST00000513407; ENSP00000475512; ENSG00000204531.
GeneIDi5460.
UCSCiuc032wqt.2. human.

Organism-specific databases

CTDi5460.
HGNCiHGNC:9221. POU5F1.
OpenTargetsiENSG00000204531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.

Miscellaneous databases

GenomeRNAii5460.

Gene expression databases

BgeeiENSG00000204531.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
PANTHERiPTHR11636:SF100. PTHR11636:SF100. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS51179. POU_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF2Z381_HUMAN
AccessioniPrimary (citable) accession number: F2Z381
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: March 15, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.