ID   FND10_HUMAN             Reviewed;         226 AA.
AC   F2Z333;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=Fibronectin type III domain-containing protein 10;
DE   Flags: Precursor;
GN   Name=FNDC10; Synonyms=C1orf233;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL691432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS55559.1; -.
DR   RefSeq; NP_001229588.1; NM_001242659.1.
DR   AlphaFoldDB; F2Z333; -.
DR   BioGRID; 569217; 2.
DR   STRING; 9606.ENSP00000389111; -.
DR   GlyCosmos; F2Z333; 2 sites, No reported glycans.
DR   GlyGen; F2Z333; 2 sites.
DR   PhosphoSitePlus; F2Z333; -.
DR   BioMuta; FNDC10; -.
DR   MassIVE; F2Z333; -.
DR   MaxQB; F2Z333; -.
DR   PaxDb; 9606-ENSP00000389111; -.
DR   PeptideAtlas; F2Z333; -.
DR   ProteomicsDB; 23877; -.
DR   DNASU; 643988; -.
DR   Ensembl; ENST00000422725.4; ENSP00000389111.1; ENSG00000228594.4.
DR   GeneID; 643988; -.
DR   KEGG; hsa:643988; -.
DR   MANE-Select; ENST00000422725.4; ENSP00000389111.1; NM_001242659.2; NP_001229588.1.
DR   UCSC; uc021oes.2; human.
DR   AGR; HGNC:42951; -.
DR   CTD; 643988; -.
DR   GeneCards; FNDC10; -.
DR   HGNC; HGNC:42951; FNDC10.
DR   HPA; ENSG00000228594; Tissue enhanced (adrenal gland, brain).
DR   neXtProt; NX_F2Z333; -.
DR   OpenTargets; ENSG00000228594; -.
DR   VEuPathDB; HostDB:ENSG00000228594; -.
DR   eggNOG; ENOG502S019; Eukaryota.
DR   GeneTree; ENSGT00550000076432; -.
DR   HOGENOM; CLU_097198_0_0_1; -.
DR   InParanoid; F2Z333; -.
DR   OMA; YTRFPCD; -.
DR   OrthoDB; 4738401at2759; -.
DR   PhylomeDB; F2Z333; -.
DR   TreeFam; TF332961; -.
DR   PathwayCommons; F2Z333; -.
DR   BioGRID-ORCS; 643988; 32 hits in 1132 CRISPR screens.
DR   ChiTaRS; FNDC10; human.
DR   GenomeRNAi; 643988; -.
DR   Pharos; F2Z333; Tdark.
DR   PRO; PR:F2Z333; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; F2Z333; Protein.
DR   Bgee; ENSG00000228594; Expressed in right adrenal gland cortex and 140 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR034446; Fndc10.
DR   PANTHER; PTHR39233; FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10; 1.
DR   PANTHER; PTHR39233:SF1; FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10; 1.
DR   Pfam; PF17742; Fndc10; 1.
DR   Genevisible; F2Z333; HS.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..226
FT                   /note="Fibronectin type III domain-containing protein 10"
FT                   /id="PRO_0000416238"
FT   TOPO_DOM        21..182
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..226
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          74..166
FT                   /note="Fibronectin type-III"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  24218 MW;  F4A076C9226DA5FE CRC64;
     MRAPPLLLLL AACAPPPCAA AAPTPPGWEP TPDAPWCPYK VLPEGPEAGG GRLCFRSPAR
     GFRCQAPGCV LHAPAGRSLR ASVLRNRSVL LQWRLAPAAA RRVRAFALNC SWRGAYTRFP
     CERVLLGASC RDYLLPDVHD SVLYRLCLQP LPLRAGPAAA APETPEPAEC VEFTAEPAGM
     QDIVVAMTAV GGSICVMLVV ICLLVAYITE NLMRPALARP GLRRHP
//