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Protein

Fibronectin type III domain-containing protein 10

Gene

FNDC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 10
Gene namesi
Name:FNDC10
Synonyms:C1orf233
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:42951. FNDC10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 182ExtracellularSequence analysisAdd BLAST162
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 226CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000228594.

Polymorphism and mutation databases

BioMutaiC1orf233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004162381 – 226Fibronectin type III domain-containing protein 10Add BLAST226
Signal peptidei1 – 20Sequence analysisAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiF2Z333.
PaxDbiF2Z333.
PRIDEiF2Z333.

Expressioni

Gene expression databases

BgeeiENSG00000228594.
GenevisibleiF2Z333. HS.

Structurei

3D structure databases

ProteinModelPortaliF2Z333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 166Fibronectin type-IIIAdd BLAST93

Sequence similaritiesi

Contains 1 fibronectin type-III domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB9U. Eukaryota.
ENOG410Z0X2. LUCA.
GeneTreeiENSGT00550000076432.
InParanoidiF2Z333.
OMAiTENLMRP.
OrthoDBiEOG091G0HGI.
PhylomeDBiF2Z333.
TreeFamiTF332961.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F2Z333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPPLLLLL AACAPPPCAA AAPTPPGWEP TPDAPWCPYK VLPEGPEAGG
60 70 80 90 100
GRLCFRSPAR GFRCQAPGCV LHAPAGRSLR ASVLRNRSVL LQWRLAPAAA
110 120 130 140 150
RRVRAFALNC SWRGAYTRFP CERVLLGASC RDYLLPDVHD SVLYRLCLQP
160 170 180 190 200
LPLRAGPAAA APETPEPAEC VEFTAEPAGM QDIVVAMTAV GGSICVMLVV
210 220
ICLLVAYITE NLMRPALARP GLRRHP
Length:226
Mass (Da):24,218
Last modified:May 31, 2011 - v1
Checksum:iF4A076C9226DA5FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691432 Genomic DNA. No translation available.
CCDSiCCDS55559.1.
RefSeqiNP_001229588.1. NM_001242659.1.
UniGeneiHs.528816.

Genome annotation databases

EnsembliENST00000422725; ENSP00000389111; ENSG00000228594.
GeneIDi643988.
KEGGihsa:643988.
UCSCiuc021oes.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691432 Genomic DNA. No translation available.
CCDSiCCDS55559.1.
RefSeqiNP_001229588.1. NM_001242659.1.
UniGeneiHs.528816.

3D structure databases

ProteinModelPortaliF2Z333.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiC1orf233.

Proteomic databases

MaxQBiF2Z333.
PaxDbiF2Z333.
PRIDEiF2Z333.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422725; ENSP00000389111; ENSG00000228594.
GeneIDi643988.
KEGGihsa:643988.
UCSCiuc021oes.2. human.

Organism-specific databases

CTDi643988.
GeneCardsiC1orf233.
HGNCiHGNC:42951. FNDC10.
neXtProtiNX_F2Z333.
OpenTargetsiENSG00000228594.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB9U. Eukaryota.
ENOG410Z0X2. LUCA.
GeneTreeiENSGT00550000076432.
InParanoidiF2Z333.
OMAiTENLMRP.
OrthoDBiEOG091G0HGI.
PhylomeDBiF2Z333.
TreeFamiTF332961.

Miscellaneous databases

GenomeRNAii643988.
PROiF2Z333.

Gene expression databases

BgeeiENSG00000228594.
GenevisibleiF2Z333. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFND10_HUMAN
AccessioniPrimary (citable) accession number: F2Z333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.