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Protein

Ribosomal protein S6 kinase

Gene

RPS6KA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei209Proton acceptorUniRule annotation1
Active sitei557Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiF2Z2J1

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S6 kinaseUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:RPS6KA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000071242.11
HGNCiHGNC:10431 RPS6KA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000071242

PTM / Processingi

Proteomic databases

EPDiF2Z2J1
MaxQBiF2Z2J1
PRIDEiF2Z2J1

Expressioni

Gene expression databases

BgeeiENSG00000071242
ExpressionAtlasiF2Z2J1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF2Z2J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 343Protein kinaseInterPro annotationAdd BLAST260
Domaini344 – 413AGC-kinase C-terminalInterPro annotationAdd BLAST70
Domaini440 – 697Protein kinaseInterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00890000139324
OMAiTMDYLHS
OrthoDBiEOG091G05Z7
PhylomeDBiF2Z2J1

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016239 Ribosomal_S6_kinase_II
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 2 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

Sequencei

Sequence statusi: Complete.

F2Z2J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIAQLLELW KKIEVEPMEI ETTEEDLNLD VEPTTEDTAE EGKSDSAACK
60 70 80 90 100
TKVAGSVEEE GVVKEIDISH HVKEGFEKAD PSQFELLKVL GQGSYGKVFL
110 120 130 140 150
VRKVKGSDAG QLYAMKVLKK ATLKVRDRVR SKMERDILAE VNHPFIVKLH
160 170 180 190 200
YAFQTEGKLY LILDFLRGGD LFTRLSKEVM FTEEDVKFYL AELALALDHL
210 220 230 240 250
HSLGIIYRDL KPENILLDEE GHIKITDFGL SKEAIDHDKR AYSFCGTIEY
260 270 280 290 300
MAPEVVNRRG HTQSADWWSF GVLMFEMLTG SLPFQGKDRK ETMALILKAK
310 320 330 340 350
LGMPQFLSGE AQSLLRALFK RNPCNRLGAG IDGVEEIKRH PFFVTIDWNT
360 370 380 390 400
LYRKEIKPPF KPAVGRPEDT FHFDPEFTAR TPTDSPGVPP SANAHHLFRG
410 420 430 440 450
FSFVASSLIQ EPSQQDLHKV PVHPIVQQLH GNNIHFTDGY EIKEDIGVGS
460 470 480 490 500
YSVCKRCVHK ATDTEYAVKI IDKSKRDPSE EIEILLRYGQ HPNIITLKDV
510 520 530 540 550
YDDGKFVYLV MELMRGGELL DRILRQRYFS EREASDVLCT ITKTMDYLHS
560 570 580 590 600
QGVVHRDLKP SNILYRDESG SPESIRVCDF GFAKQLRAGN GLLMTPCYTA
610 620 630 640 650
NFVAPEVLKR QGYDAACDIW SLGILLYTML AGFTPFANGP DDTPEEILAR
660 670 680 690 700
IGSGKYALSG GNWDSISDAA KDVVSKMLHV DPHQRLTAMQ VLKHPWVVNR
710 720 730 740 750
EYLSPNQLSR QDVHLVKGAM AATYFALNRT PQAPRLEPVL SSNLAQRRGM

KRLTSTRL
Length:758
Mass (Da):85,634
Last modified:May 31, 2011 - v1
Checksum:i4A8F04DBD7A4DBA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022069 Genomic DNA No translation available.
AL023775 Genomic DNA No translation available.
AL159163 Genomic DNA No translation available.
Z98049 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000510118; ENSP00000422435; ENSG00000071242
UCSCiuc003qvd.2 human

Entry informationi

Entry nameiF2Z2J1_HUMAN
AccessioniPrimary (citable) accession number: F2Z2J1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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