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Protein
Submitted name:

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Gene

PFKFB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3Imported
Gene namesi
Name:PFKFB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:8874. PFKFB3.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170525.

Expressioni

Gene expression databases

BgeeiENSG00000170525.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369100.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 2466PF2KInterPro annotationAdd BLAST221

Phylogenomic databases

eggNOGiKOG0234. Eukaryota.
COG0406. LUCA.
GeneTreeiENSGT00390000018751.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
IPR001345. PG/BPGM_mutase_AS.
PANTHERiPTHR10606. PTHR10606. 1 hit.
PfamiView protein in Pfam
PF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
PRINTSiPR00991. 6PFRUCTKNASE.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F2Z2I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY
60 70 80 90 100
ISKKLTRYLN WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMKVRK
110 120 130 140 150
QCALAALRDV KSYLAKEGGQ IAVFDATNTT RERRHMILHF AKENDFKAFF
160 170 180 190 200
IESVCDDPTV VASNIMEVKI SSPDYKDCNS AEAMDDFMKR ISCYEASYQP
210 220 230 240 250
LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM NIHVQPRTIY
260 270 280 290 300
LCRHGENEHN LQGRIGGDSG LSSRGKKFAS ALSKFVEEQN LKDLRVWTSQ
310 320 330 340 350
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ
360 370 380 390 400
DKYYYRYPTG ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL
410 420 430 440 450
DKSAEEMPYL KCPLHTVLKL TPVAYGCRVE SIYLNVESVC THRERSEAAK

STTLC
Length:455
Mass (Da):52,584
Last modified:May 31, 2011 - v1
Checksum:iC15D55848EE21267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157395 Genomic DNA. No translation available.
AL359960 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000461744; ENSP00000433771; ENSG00000170525.
ENST00000467491; ENSP00000434628; ENSG00000170525.
ENST00000477914; ENSP00000432356; ENSG00000170525.
ENST00000490474; ENSP00000436885; ENSG00000170525.
ENST00000625260; ENSP00000486311; ENSG00000170525.
UCSCiuc057rmu.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157395 Genomic DNA. No translation available.
AL359960 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000461744; ENSP00000433771; ENSG00000170525.
ENST00000467491; ENSP00000434628; ENSG00000170525.
ENST00000477914; ENSP00000432356; ENSG00000170525.
ENST00000490474; ENSP00000436885; ENSG00000170525.
ENST00000625260; ENSP00000486311; ENSG00000170525.
UCSCiuc057rmu.1. human.

Organism-specific databases

HGNCiHGNC:8874. PFKFB3.
OpenTargetsiENSG00000170525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0234. Eukaryota.
COG0406. LUCA.
GeneTreeiENSGT00390000018751.

Miscellaneous databases

ChiTaRSiPFKFB3. human.

Gene expression databases

BgeeiENSG00000170525.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003094. 6Pfruct_kin.
IPR013079. 6Phosfructo_kin.
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR027417. P-loop_NTPase.
IPR001345. PG/BPGM_mutase_AS.
PANTHERiPTHR10606. PTHR10606. 1 hit.
PfamiView protein in Pfam
PF01591. 6PF2K. 1 hit.
PF00300. His_Phos_1. 1 hit.
PRINTSiPR00991. 6PFRUCTKNASE.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53254. SSF53254. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF2Z2I2_HUMAN
AccessioniPrimary (citable) accession number: F2Z2I2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: March 15, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.