F2XBU9 (F2XBU9_VIBFL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Pyruvate transaminase EMBL AEA39183.1
Organism	Vibrio fluvialis EMBL AEA39183.1
Taxonomic identifier	676 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. RuleBase RU003560

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU003560 Pyruvate EMBL AEA39183.1
Technical term	3D-structure PDB 3NUI PDB 4E3Q PDB 4E3R
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F2XBU9 [UniParc]. Last modified May 31, 2011. Version 1. Checksum: 882C67989E909154	FASTA	453	50,131
	10 20 30 40 50 60 MNKPQSWEAR AETYSLYGFT DMPSLHQRGT VVVTHGEGPY IVDVNGRRYL DANSGLWNMV 70 80 90 100 110 120 AGFDHKGLID AAKAQYERFP GYHAFFGRMS DQTVMLSEKL VEVSPFDSGR VFYTNSGSEA 130 140 150 160 170 180 NDTMVKMLWF LHAAEGKPQK RKILTRWNAY HGVTAVSASM TGKPYNSVFG LPLPGFVHLT 190 200 210 220 230 240 CPHYWRYGEE GETEEQFVAR LARELEETIQ REGADTIAGF FAEPVMGAGG VIPPAKGYFQ 250 260 270 280 290 300 AILPILRKYD IPVISDEVIC GFGRTGNTWG CVTYDFTPDA IISSKNLTAG FFPMGAVILG 310 320 330 340 350 360 PELSKRLETA IEAIEEFPHG FTASGHPVGC AIALKAIDVV MNEGLAENVR RLAPRFEERL 370 380 390 400 410 420 KHIAERPNIG EYRGIGFMWA LEAVKDKASK TPFDGNLSVS ERIANTCTDL GLICRPLGQS 430 440 450 VVLCPPFILT EAQMDEMFDK LEKALDKVFA EVA

References

[1]	"Purification, characterization, and molecular cloning of a novel amine:pyruvate transaminase from Vibrio fluvialis JS17." Shin J.S., Yun H., Jang J.W., Park I., Kim B.G. Appl. Microbiol. Biotechnol. 61:463-471(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: JS17 EMBL AEA39183.1.
[2]	"Crystal structure of the first omega-transaminase at 2.0A resolution." Park H.H., Jang T. Submitted (JUL-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[3]	Shin J.-S., Yun H., Jang J.-W., Park I., Kim B.-G. Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: JS17 EMBL AEA39183.1.
[4]	"Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin." Midelfort K.S., Kumar R., Han S., Karmilowicz M.J., McConnell K., Gehlhaar D.K., Mistry A., Chang J.S., Anderson M., Villalobos A., Minshull J., Govindarajan S., Wong J.W. Protein Eng. Des. Sel. 26:25-33(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

HQ418483 Genomic DNA. Translation: AEA39183.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3NUI	X-ray	2.00	A/B	1-453	[»]
4E3Q	X-ray	1.90	A/B/C/D	1-453	[»]
4E3R	X-ray	1.90	A/B/C/D	1-453	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Enzyme and pathway databases

BioCyc

MetaCyc:MONOMER-17645.

Family and domain databases

Gene3D

3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.

InterPro

IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

PANTHER

PTHR11986. PTHR11986. 1 hit.

Pfam

PF00202. Aminotran_3. 1 hit.
[Graphical view]

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

PROSITE

PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

F2XBU9.

Entry information

Entry name

F2XBU9_VIBFL

Accession

Primary (citable) accession number: F2XBU9

Entry history

Integrated into UniProtKB/TrEMBL:	May 31, 2011
Last sequence update:	May 31, 2011
Last modified:	May 1, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)