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Protein
Submitted name:

Pyruvate transaminase

Gene
N/A
Organism
Vibrio fluvialis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17645.

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate transaminaseImported
OrganismiVibrio fluvialisImported
Taxonomic identifieri676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NUIX-ray2.00A/B1-453[»]
4E3QX-ray1.90A/B/C/D1-453[»]
4E3RX-ray1.90A/B/C/D1-453[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiF2XBU9.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2XBU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPQSWEAR AETYSLYGFT DMPSLHQRGT VVVTHGEGPY IVDVNGRRYL
60 70 80 90 100
DANSGLWNMV AGFDHKGLID AAKAQYERFP GYHAFFGRMS DQTVMLSEKL
110 120 130 140 150
VEVSPFDSGR VFYTNSGSEA NDTMVKMLWF LHAAEGKPQK RKILTRWNAY
160 170 180 190 200
HGVTAVSASM TGKPYNSVFG LPLPGFVHLT CPHYWRYGEE GETEEQFVAR
210 220 230 240 250
LARELEETIQ REGADTIAGF FAEPVMGAGG VIPPAKGYFQ AILPILRKYD
260 270 280 290 300
IPVISDEVIC GFGRTGNTWG CVTYDFTPDA IISSKNLTAG FFPMGAVILG
310 320 330 340 350
PELSKRLETA IEAIEEFPHG FTASGHPVGC AIALKAIDVV MNEGLAENVR
360 370 380 390 400
RLAPRFEERL KHIAERPNIG EYRGIGFMWA LEAVKDKASK TPFDGNLSVS
410 420 430 440 450
ERIANTCTDL GLICRPLGQS VVLCPPFILT EAQMDEMFDK LEKALDKVFA

EVA
Length:453
Mass (Da):50,131
Last modified:May 31, 2011 - v1
Checksum:i882C67989E909154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ418483 Genomic DNA. Translation: AEA39183.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ418483 Genomic DNA. Translation: AEA39183.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NUIX-ray2.00A/B1-453[»]
4E3QX-ray1.90A/B/C/D1-453[»]
4E3RX-ray1.90A/B/C/D1-453[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17645.

Miscellaneous databases

EvolutionaryTraceiF2XBU9.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Purification, characterization, and molecular cloning of a novel amine:pyruvate transaminase from Vibrio fluvialis JS17."
    Shin J.S., Yun H., Jang J.W., Park I., Kim B.G.
    Appl. Microbiol. Biotechnol. 61:463-471(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JS17Imported.
  2. "Crystal structure of the first omega-transaminase at 2.0A resolution."
    Park H.H., Jang T.
    Submitted (JUL-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  3. Shin J.-S., Yun H., Jang J.-W., Park I., Kim B.-G.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JS17Imported.
  4. "Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin."
    Midelfort K.S., Kumar R., Han S., Karmilowicz M.J., McConnell K., Gehlhaar D.K., Mistry A., Chang J.S., Anderson M., Villalobos A., Minshull J., Govindarajan S., Wong J.W.
    Protein Eng. Des. Sel. 26:25-33(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).

Entry informationi

Entry nameiF2XBU9_VIBFL
AccessioniPrimary (citable) accession number: F2XBU9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: January 7, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.