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F2XBU9

- F2XBU9_VIBFL

UniProt

F2XBU9 - F2XBU9_VIBFL

Protein
Submitted name:

Pyruvate transaminase

Gene
N/A
Organism
Vibrio fluvialis
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Sodium; via carbonyl oxygenImported
    Metal bindingi102 – 1021SodiumImported
    Metal bindingi104 – 1041Sodium; via carbonyl oxygenImported
    Metal bindingi106 – 1061Sodium; via carbonyl oxygenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17645.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pyruvate transaminaseImported
    OrganismiVibrio fluvialisImported
    Taxonomic identifieri676 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NUIX-ray2.00A/B1-453[»]
    4E3QX-ray1.90A/B/C/D1-453[»]
    4E3RX-ray1.90A/B/C/D1-453[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiF2XBU9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2XBU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKPQSWEAR AETYSLYGFT DMPSLHQRGT VVVTHGEGPY IVDVNGRRYL    50
    DANSGLWNMV AGFDHKGLID AAKAQYERFP GYHAFFGRMS DQTVMLSEKL 100
    VEVSPFDSGR VFYTNSGSEA NDTMVKMLWF LHAAEGKPQK RKILTRWNAY 150
    HGVTAVSASM TGKPYNSVFG LPLPGFVHLT CPHYWRYGEE GETEEQFVAR 200
    LARELEETIQ REGADTIAGF FAEPVMGAGG VIPPAKGYFQ AILPILRKYD 250
    IPVISDEVIC GFGRTGNTWG CVTYDFTPDA IISSKNLTAG FFPMGAVILG 300
    PELSKRLETA IEAIEEFPHG FTASGHPVGC AIALKAIDVV MNEGLAENVR 350
    RLAPRFEERL KHIAERPNIG EYRGIGFMWA LEAVKDKASK TPFDGNLSVS 400
    ERIANTCTDL GLICRPLGQS VVLCPPFILT EAQMDEMFDK LEKALDKVFA 450
    EVA 453
    Length:453
    Mass (Da):50,131
    Last modified:May 31, 2011 - v1
    Checksum:i882C67989E909154
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ418483 Genomic DNA. Translation: AEA39183.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ418483 Genomic DNA. Translation: AEA39183.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NUI X-ray 2.00 A/B 1-453 [» ]
    4E3Q X-ray 1.90 A/B/C/D 1-453 [» ]
    4E3R X-ray 1.90 A/B/C/D 1-453 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17645.

    Miscellaneous databases

    EvolutionaryTracei F2XBU9.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification, characterization, and molecular cloning of a novel amine:pyruvate transaminase from Vibrio fluvialis JS17."
      Shin J.S., Yun H., Jang J.W., Park I., Kim B.G.
      Appl. Microbiol. Biotechnol. 61:463-471(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JS17Imported.
    2. "Crystal structure of the first omega-transaminase at 2.0A resolution."
      Park H.H., Jang T.
      Submitted (JUL-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
    3. Shin J.-S., Yun H., Jang J.-W., Park I., Kim B.-G.
      Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JS17Imported.
    4. "Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin."
      Midelfort K.S., Kumar R., Han S., Karmilowicz M.J., McConnell K., Gehlhaar D.K., Mistry A., Chang J.S., Anderson M., Villalobos A., Minshull J., Govindarajan S., Wong J.W.
      Protein Eng. Des. Sel. 26:25-33(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).

    Entry informationi

    Entry nameiF2XBU9_VIBFL
    AccessioniPrimary (citable) accession number: F2XBU9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3