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F2XBU9

- F2XBU9_VIBFL

UniProt

F2XBU9 - F2XBU9_VIBFL

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Protein
Submitted name:

Pyruvate transaminase

Gene
N/A
Organism
Vibrio fluvialis
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Sodium; via carbonyl oxygenImported
Metal bindingi102 – 1021SodiumImported
Metal bindingi104 – 1041Sodium; via carbonyl oxygenImported
Metal bindingi106 – 1061Sodium; via carbonyl oxygenImported

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-bindingImported, Pyridoxal phosphateUniRule annotation, PyruvateImported, SodiumImported

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17645.

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate transaminaseImported
OrganismiVibrio fluvialisImported
Taxonomic identifieri676 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NUIX-ray2.00A/B1-453[»]
4E3QX-ray1.90A/B/C/D1-453[»]
4E3RX-ray1.90A/B/C/D1-453[»]

Miscellaneous databases

EvolutionaryTraceiF2XBU9.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2XBU9-1 [UniParc]FASTAAdd to Basket

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MNKPQSWEAR AETYSLYGFT DMPSLHQRGT VVVTHGEGPY IVDVNGRRYL    50
DANSGLWNMV AGFDHKGLID AAKAQYERFP GYHAFFGRMS DQTVMLSEKL 100
VEVSPFDSGR VFYTNSGSEA NDTMVKMLWF LHAAEGKPQK RKILTRWNAY 150
HGVTAVSASM TGKPYNSVFG LPLPGFVHLT CPHYWRYGEE GETEEQFVAR 200
LARELEETIQ REGADTIAGF FAEPVMGAGG VIPPAKGYFQ AILPILRKYD 250
IPVISDEVIC GFGRTGNTWG CVTYDFTPDA IISSKNLTAG FFPMGAVILG 300
PELSKRLETA IEAIEEFPHG FTASGHPVGC AIALKAIDVV MNEGLAENVR 350
RLAPRFEERL KHIAERPNIG EYRGIGFMWA LEAVKDKASK TPFDGNLSVS 400
ERIANTCTDL GLICRPLGQS VVLCPPFILT EAQMDEMFDK LEKALDKVFA 450
EVA 453
Length:453
Mass (Da):50,131
Last modified:May 31, 2011 - v1
Checksum:i882C67989E909154
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ418483 Genomic DNA. Translation: AEA39183.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ418483 Genomic DNA. Translation: AEA39183.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NUI X-ray 2.00 A/B 1-453 [» ]
4E3Q X-ray 1.90 A/B/C/D 1-453 [» ]
4E3R X-ray 1.90 A/B/C/D 1-453 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17645.

Miscellaneous databases

EvolutionaryTracei F2XBU9.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification, characterization, and molecular cloning of a novel amine:pyruvate transaminase from Vibrio fluvialis JS17."
    Shin J.S., Yun H., Jang J.W., Park I., Kim B.G.
    Appl. Microbiol. Biotechnol. 61:463-471(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JS17Imported.
  2. "Crystal structure of the first omega-transaminase at 2.0A resolution."
    Park H.H., Jang T.
    Submitted (JUL-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
  3. Shin J.-S., Yun H., Jang J.-W., Park I., Kim B.-G.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JS17Imported.
  4. "Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin."
    Midelfort K.S., Kumar R., Han S., Karmilowicz M.J., McConnell K., Gehlhaar D.K., Mistry A., Chang J.S., Anderson M., Villalobos A., Minshull J., Govindarajan S., Wong J.W.
    Protein Eng. Des. Sel. 26:25-33(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH SODIUM.

Entry informationi

Entry nameiF2XBU9_VIBFL
AccessioniPrimary (citable) accession number: F2XBU9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: September 3, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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