Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Catechol-O-methyltransferase

Gene

Comt

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei115S-adenosyl-L-methionineUniRule annotation1
Binding sitei133S-adenosyl-L-methionineUniRule annotation1
Metal bindingi184MagnesiumUniRule annotation1
Binding sitei184S-adenosyl-L-methionineUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Metal bindingi212MagnesiumUniRule annotation1
Metal bindingi213MagnesiumUniRule annotation1
Binding sitei213SubstrateUniRule annotation1
Binding sitei242SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferaseImported, Transferase
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Catechol-O-methyltransferaseImported
Submitted name:
Catechol-O-methyltransferase, isoform CRA_aImported
Gene namesi
Name:ComtImported
ORF Names:rCG_36721Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2379 Comt

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiF2W8B0

Expressioni

Gene expression databases

BgeeiENSRNOG00000001889
ExpressionAtlasiF2W8B0 baseline and differential

Structurei

3D structure databases

SMRiF2W8B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 163S-adenosyl-L-methionine bindingUniRule annotation4

Phylogenomic databases

eggNOGiKOG1663 Eukaryota
COG4122 LUCA
KOiK00545
OMAiSRFECTH
OrthoDBiEOG091G0GQK

Family and domain databases

InterProiView protein in InterPro
IPR017128 Catechol_O-MeTrfase_euk
IPR002935 O-MeTrfase_3
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01596 Methyltransf_3, 1 hit
PIRSFiPIRSF037177 Catechol_O-mtfrase_euk, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51682 SAM_OMT_I, 1 hit

Sequencei

Sequence statusi: Complete.

F2W8B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAAVSLGL LLLALLLLLR HLGWGLVTIF WFEYVLQPVH NLIMGDTKEQ
60 70 80 90 100
RILRYVQQNA KPGDPQSVLE AIDTYCTQKE WAMNVGDAKG QIMDAVIREY
110 120 130 140 150
SPSLVLELGA YCGYSAVRMA RLLQPGARLL TMEMNPDYAA ITQQMLNFAG
160 170 180 190 200
LQDKVTILNG ASQDLIPQLK KKYDVDTLDM VFLDHWKDRY LPDTLLLEKC
210 220 230 240 250
GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY LEYMKVVDGL
260
EKAIYQGPSS PDKS
Length:264
Mass (Da):29,597
Last modified:May 31, 2011 - v1
Checksum:iF535DFF49C062854
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM443074 Genomic DNA Translation: AEA41111.1
HM443075 Genomic DNA Translation: AEA41112.1
CH473999 Genomic DNA Translation: EDL77940.1
RefSeqiNP_036663.1, NM_012531.2
UniGeneiRn.220

Genome annotation databases

GeneIDi24267
KEGGirno:24267

Similar proteinsi

Entry informationi

Entry nameiF2W8B0_RAT
AccessioniPrimary (citable) accession number: F2W8B0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health