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F2RJX4

- F2RJX4_STRVP

UniProt

F2RJX4 - F2RJX4_STRVP

Protein

Alanine racemase

Gene

SVEN_4422

Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (31 May 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Active sitei274 – 2741Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei322 – 3221Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSVEN953739-WGS:GSXO-4491-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:SVEN_4422Imported
    OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)Imported
    Taxonomic identifieri953739 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000006854: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF2RJX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F2RJX4-1 [UniParc]FASTAAdd to Basket

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    MTETPPPRRA RAEIDLGALR ANVRTLRARV APHVRIMAVV KADAYGHGAV    50
    RCARAALDAG ADWLGTATPH EALALRAAGI TDVPVMCWLW TPGDPWDQGI 100
    EAGLDMSVSG MWALEEVVRA ARATGGVARV QLKADTGLGR NGCQPADWPE 150
    LVGEALKAEA EGLVEVTGLW SHFACADEPH HPSIAAQLDV FRSMLDYAEK 200
    AGVRPEVRHI ANSPATLTLP EAHFDLVRPG IAMYGVSPSP ELGTSAELGL 250
    RPVMSLKASV ALVKRVPAGH GVSYGHHYVT DAETTLGLVP LGYADGVPRH 300
    ASGRGPVLVD GTVRTVAGRV AMDQFVVDLG GDVPAPGTEA VLFGPGDLGE 350
    PTAEDWAVAA DTIAYEIVTR IGARVPRVYL GE 382
    Length:382
    Mass (Da):40,210
    Last modified:May 31, 2011 - v1
    Checksum:i354E8FA1AB2CC23D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR845719 Genomic DNA. Translation: CCA57708.1.
    RefSeqiWP_015035610.1. NC_018750.1.
    YP_006879967.1. NC_018750.1.

    Genome annotation databases

    EnsemblBacteriaiCCA57708; CCA57708; SVEN_4422.
    GeneIDi13819580.
    KEGGisve:SVEN_4422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FR845719 Genomic DNA. Translation: CCA57708.1 .
    RefSeqi WP_015035610.1. NC_018750.1.
    YP_006879967.1. NC_018750.1.

    3D structure databases

    ProteinModelPortali F2RJX4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCA57708 ; CCA57708 ; SVEN_4422 .
    GeneIDi 13819580.
    KEGGi sve:SVEN_4422.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SVEN953739-WGS:GSXO-4491-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes."
      Pullan S.T., Chandra G., Bibb M.J., Merrick M.
      BMC Genomics 12:175-175(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745Imported.

    Entry informationi

    Entry nameiF2RJX4_STRVP
    AccessioniPrimary (citable) accession number: F2RJX4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 31, 2011
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3