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F2RAK9

- F2RAK9_STRVP

UniProt

F2RAK9 - F2RAK9_STRVP

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Protein

Kynureninase

Gene

kynU

Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei100 – 1001Pyridoxal phosphateUniRule annotation
Binding sitei197 – 1971Pyridoxal phosphateUniRule annotation
Binding sitei200 – 2001Pyridoxal phosphateUniRule annotation
Binding sitei222 – 2221Pyridoxal phosphateUniRule annotation
Binding sitei252 – 2521Pyridoxal phosphateUniRule annotation
Binding sitei278 – 2781Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSVEN953739-WGS:GSXO-3447-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:SVEN_3405Imported
OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)Imported
Taxonomic identifieri953739 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000006854: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei223 – 2231N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1314Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

F2RAK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLLRDRAL ELDAADGLGK HREKFALDAA TVYLDGNSLG ALPAHVPARM
60 70 80 90 100
ADVITREWGE LRIRSWDESG WWTAPERIGD RIAPIVGAAP GQIVVGDSTS
110 120 130 140 150
VNVFKAVVAA ARLNGDDRGE ILVDATTFPT DGYIARSAAR MTGHEIVACD
160 170 180 190 200
PADMPAAVSG RTAAALVNHV DYRTGRLHDL PGITAALHAA GALAVWDLCH
210 220 230 240 250
SAGALPVGLD AHRVDLAVGC TYKYLNGGPG SPAYLYVAER HQAAFDSPLP
260 270 280 290 300
GWNSHADPFG MTPGYAAAEG AAKGRVGTPD ILSMLALEAS LDVWDGVDVE
310 320 330 340 350
DVRAKSLALT DFFLECVRAY VPAGRVRSVT PEAHAERGSQ AALSCENAPA
360 370 380 390 400
VMAELIKRGV VGDLRRPDVL RFGFTPLYVG FADAERAARV LADVLAELPA
Length:400
Mass (Da):42,260
Last modified:May 31, 2011 - v1
Checksum:i5774C49814DE16C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR845719 Genomic DNA. Translation: CCA56691.1.
RefSeqiWP_015034606.1. NC_018750.1.
YP_006878950.1. NC_018750.1.

Genome annotation databases

EnsemblBacteriaiCCA56691; CCA56691; SVEN_3405.
GeneIDi13821230.
KEGGisve:SVEN_3405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR845719 Genomic DNA. Translation: CCA56691.1 .
RefSeqi WP_015034606.1. NC_018750.1.
YP_006878950.1. NC_018750.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCA56691 ; CCA56691 ; SVEN_3405 .
GeneIDi 13821230.
KEGGi sve:SVEN_3405.

Phylogenomic databases

KOi K01556.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci SVEN953739-WGS:GSXO-3447-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes."
    Pullan S.T., Chandra G., Bibb M.J., Merrick M.
    BMC Genomics 12:175-175(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745Imported.

Entry informationi

Entry nameiF2RAK9_STRVP
AccessioniPrimary (citable) accession number: F2RAK9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3