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Protein

Kynureninase

Gene

kynU

Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei100Pyridoxal phosphateUniRule annotation1
Binding sitei197Pyridoxal phosphateUniRule annotation1
Binding sitei200Pyridoxal phosphateUniRule annotation1
Binding sitei222Pyridoxal phosphateUniRule annotation1
Binding sitei252Pyridoxal phosphateUniRule annotation1
Binding sitei278Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:SVEN_3405Imported
OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)Imported
Taxonomic identifieri953739 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000006854 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 319Aminotran_5InterPro annotationAdd BLAST246

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 131Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

KOiK01556
OMAiGWYGGDK
OrthoDBiPOG091H0D63

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

F2RAK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLLRDRAL ELDAADGLGK HREKFALDAA TVYLDGNSLG ALPAHVPARM
60 70 80 90 100
ADVITREWGE LRIRSWDESG WWTAPERIGD RIAPIVGAAP GQIVVGDSTS
110 120 130 140 150
VNVFKAVVAA ARLNGDDRGE ILVDATTFPT DGYIARSAAR MTGHEIVACD
160 170 180 190 200
PADMPAAVSG RTAAALVNHV DYRTGRLHDL PGITAALHAA GALAVWDLCH
210 220 230 240 250
SAGALPVGLD AHRVDLAVGC TYKYLNGGPG SPAYLYVAER HQAAFDSPLP
260 270 280 290 300
GWNSHADPFG MTPGYAAAEG AAKGRVGTPD ILSMLALEAS LDVWDGVDVE
310 320 330 340 350
DVRAKSLALT DFFLECVRAY VPAGRVRSVT PEAHAERGSQ AALSCENAPA
360 370 380 390 400
VMAELIKRGV VGDLRRPDVL RFGFTPLYVG FADAERAARV LADVLAELPA
Length:400
Mass (Da):42,260
Last modified:May 31, 2011 - v1
Checksum:i5774C49814DE16C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR845719 Genomic DNA Translation: CCA56691.1
RefSeqiWP_015034606.1, NC_018750.1

Genome annotation databases

EnsemblBacteriaiCCA56691; CCA56691; SVEN_3405
KEGGisve:SVEN_3405
PATRICifig|953739.5.peg.5630

Similar proteinsi

Entry informationi

Entry nameiF2RAK9_STRVP
AccessioniPrimary (citable) accession number: F2RAK9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: May 23, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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