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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351UniRule annotation
Active sitei567 – 5671UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSVEN953739-WGS:GSXO-2983-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:SVEN_2951Imported
OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)Imported
Taxonomic identifieri953739 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000006854 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F2R7F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSADQTPTA SAELRADIRR LGDLLGETLV RQEGHELLDL VERVRSLTRE
60 70 80 90 100
DGEAAAELLR GVELETAAKL VRAFSTYFHL ANVTEQVHRG REMREKRAAE
110 120 130 140 150
GGLLARTADM LKDGDPEHVR ETVKNLNVRP VFTAHPTEAA RRSVLNKLRR
160 170 180 190 200
IGALLETPVI EADRRRHDLR LAENIDLIWQ TDELRVVRPE PADEARNAIY
210 220 230 240 250
YLDELHAGAV GDVLEDLAAE LERVGFELPS GTRPLTFGTW IGGDRDGNPN
260 270 280 290 300
VTPQVTWDVL ILQHEHGITD ALELVDFLRG LLSNSIRYAG ATQELLDSLQ
310 320 330 340 350
RDLELLPEIS PRYKRLNAEE PYRLKATCIR QKLVNTRERL ASGTPHQDGR
360 370 380 390 400
DYLGTAELVH DLTLIQTSLR EHRGGLFADG RMDRTIRTLS AFGLQLATMD
410 420 430 440 450
VREHADAHHH TLGQLFDRLG EESWRYADMP RDYRQKLLAK ELRSRRPLAP
460 470 480 490 500
TPAPLDAAGE KTLGVFHTIK QAFERFGPEV IESYIISMCQ GADDVFAAAV
510 520 530 540 550
LAREAGLIDL HAGWAKIGIV PLLETTDELK AADVILDGML ADPSYRRLVS
560 570 580 590 600
LRGDVQEVML GYSDSSKFGG ITTSQWEIHR AQRRLRDVAH RYGVRLRLFH
610 620 630 640 650
GRGGTVGRGG GPSHDAILAQ PWGTLEAEIK VTEQGEVISD KYLIPSLARE
660 670 680 690 700
NLELTVAATL QASALHTAPR QSDEALARWD AAMDVVSDAA HAAYRRLVED
710 720 730 740 750
PDLPTYFLAS TPVDQLADLH LGSRPSRRPG SGVSLDGLRA IPWVFGWTQS
760 770 780 790 800
RQIVPGWFGV GSGLKALREA GLDAVLGEMH ERWHFFRNFL SNVEMTLAKT
810 820 830 840 850
DLRIARHYVD TLVPDELKHV FDTIEAEHAL TVAEVLKVTG GEKLLDSNPV
860 870 880 890 900
LQQTFAIRDA YLDPISYLQV ALLARQRGAA ERGEEPDPLL ARALLLTVNG

VAAGLRNTG
Length:909
Mass (Da):101,018
Last modified:May 31, 2011 - v1
Checksum:i8915B32A88546EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR845719 Genomic DNA. Translation: CCA56237.1.
RefSeqiWP_015034153.1. NC_018750.1.
YP_006878496.1. NC_018750.1.

Genome annotation databases

EnsemblBacteriaiCCA56237; CCA56237; SVEN_2951.
KEGGisve:SVEN_2951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR845719 Genomic DNA. Translation: CCA56237.1.
RefSeqiWP_015034153.1. NC_018750.1.
YP_006878496.1. NC_018750.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCA56237; CCA56237; SVEN_2951.
KEGGisve:SVEN_2951.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciSVEN953739-WGS:GSXO-2983-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes."
    Pullan S.T., Chandra G., Bibb M.J., Merrick M.
    BMC Genomics 12:175-175(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745Imported.

Entry informationi

Entry nameiF2R7F2_STRVP
AccessioniPrimary (citable) accession number: F2R7F2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: April 1, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.