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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi323Magnesium or manganese 1UniRule annotation1
Metal bindingi336Magnesium or manganese 1UniRule annotation1
Metal bindingi336Magnesium or manganese 2UniRule annotation1
Metal bindingi338Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:SVEN_5252Imported
OrganismiStreptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)Imported
Taxonomic identifieri953739 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000006854 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 369ATP-graspInterPro annotationAdd BLAST211

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom_sf.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F2R5D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENTQSPRK PRVAVVFGGR SSEHAISVVT AGAVLSAIDR DKYDVLPIGI
60 70 80 90 100
TTDGRWALTA DAPERMAIAD RALPNVADLA ESETGGVVLS VDPADRQVVL
110 120 130 140 150
TEPGAVPKAL GEVDVVFPML HGPYGEDGTL QGLLELSGVP YVGAGVLASA
160 170 180 190 200
VGQDKEYMKR VFVSFGLPVG PYEVIRPREW EQNPAAARKK IVEFAAEHGW
210 220 230 240 250
PLFVKPARGG SSMGITKVDD LSGLDEAIEE ARRHDPKILV ESLLRGREIE
260 270 280 290 300
CGVLEFEDGP RASVPAEIPP VTNHDFYDFE AKYIDSASGI VPAPIGDEAT
310 320 330 340 350
AEIQRLAVAA YEAVSCEGLV RADFFLTEDG DFVINEINTM PGFTPISMYP
360 370
RMWQESGVSY PELVDRLIQA ALTRSTGLR
Length:379
Mass (Da):40,860
Last modified:May 31, 2011 - v1
Checksum:i7173473E226A0CD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR845719 Genomic DNA. Translation: CCA58538.1.
RefSeqiWP_015036436.1. NC_018750.1.

Genome annotation databases

EnsemblBacteriaiCCA58538; CCA58538; SVEN_5252.
GeneIDi28673135.
KEGGisve:SVEN_5252.
PATRICifig|953739.5.peg.390.

Similar proteinsi

Entry informationi

Entry nameiF2R5D4_STRVP
AccessioniPrimary (citable) accession number: F2R5D4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 31, 2011
Last sequence update: May 31, 2011
Last modified: November 22, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported